A5065115425- MicroRNA in disease regulation
- interferon and immune responses
- Epigenetics and DNA Methylation
- Ocular Oncology and Treatments
- Diabetes Treatment and Management
- Retinoids in leukemia and cellular processes
- melanin and skin pigmentation
- Regulation of Appetite and Obesity
- Neonatal Respiratory Health Research
- Acute Myocardial Infarction Research
- Aortic aneurysm repair treatments
- Digestive system and related health
- Gut microbiota and health
- Diabetes Management and Research
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Macrophage Migration Inhibitory Factor
- Signaling Pathways in Disease
- Inflammation biomarkers and pathways
- PI3K/AKT/mTOR signaling in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
Shandong University
2024-2025
Wenzhou Medical University
2005-2021
First Affiliated Hospital of Wenzhou Medical University
2016
ABSTRACT Osimertinib resistance remains a significant challenge in the treatment of non‐small cell lung cancer (NSCLC). N 6 ‐methyladenosine (m A) modifications are closely linked to various mechanisms anticancer and autophagy, offering new avenues for targeted therapies. However, role m A‐mediated autophagy osimertinib‐resistant NSCLC is still unclear. In this study, we utilized multi‐omics sequencing analysis found that overexpression A methyltransferase METTL3 contributes osimertinib...
Glucagon-like peptide 1 (GLP-1), a kind of gut hormone, is used in the treatment type 2 diabetes (T2D). Emerging evidence indicates that GLP-1 has anti-inflammatory activity. Chronic inflammation adipose tissue obese individuals cause insulin resistance and T2D. We hypothesized analogue therapy patients with T2D could suppress inflammatory response macrophages, therefore inhibit resistance. Our results showed agonist (exendin-4) not only attenuated macrophage infiltration, but also inhibited...
Gut Universe Database (GutUDB) provides a comprehensive, systematic, and practical platform for researchers, is dedicated to the management, analysis, visualization of knowledge related intestinal diseases. Based on this database, eight major categories omics data analyses are carried out explore genotype-phenotype characteristics certain disease. The first tool comprehensive research diseases will help each researcher better understand intestine serves as central organ in digestive system...