A5072626293- RNA modifications and cancer
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- HIV Research and Treatment
- Cancer-related gene regulation
- HIV/AIDS drug development and treatment
- RNA and protein synthesis mechanisms
- Plant Disease Resistance and Genetics
- Tannin, Tannase and Anticancer Activities
- Tryptophan and brain disorders
- Cancer, Lipids, and Metabolism
- Electrochemical Analysis and Applications
- RNA regulation and disease
- DNA and Nucleic Acid Chemistry
- Cytomegalovirus and herpesvirus research
- Fungal Infections and Studies
- Computational Drug Discovery Methods
- Microbial Community Ecology and Physiology
- Microbial Natural Products and Biosynthesis
- COVID-19 Clinical Research Studies
- Viral-associated cancers and disorders
- Electrochemical sensors and biosensors
Guangxi Medical University
2019-2024
Central China Normal University
2013
Abstract As the most abundant messenger RNA (mRNA) modification, N6-methyladenosine (m6A) plays a crucial role in fate, impacting cellular and physiological processes various tumor types. However, our understanding of m6A methylome heterogeneity remains limited. Herein, we collected analyzed methylomes across nine human tissues from 97 sequencing (m6A-seq) (RNA-seq) samples. Our findings demonstrate that exhibits different compared to normal tissues, which contributes diverse clinical...
The monkeypox outbreak has become a global public health emergency. lack of valid and safe medicine is crucial obstacle hindering the extermination orthopoxvirus infections. identification potential inhibitors from natural products, including Traditional Chinese Medicine (TCM), by molecular modeling could expand arsenal antiviral chemotherapeutic agents. Monkeypox DNA topoisomerase I (TOP1) highly conserved viral repair enzyme with small size low homology to human proteins. protein model...
The coronavirus disease 2019 (COVID-19) pandemic has caused many deaths worldwide. To date, the mechanism of viral immune escape remains unclear, which is a great obstacle to developing effective clinical treatment. RNA processing mechanisms, including alternative polyadenylation (APA) and splicing (AS), are crucial in regulation most human genes types infectious diseases. Because role APA AS response severe acute respiratory syndrome 2 (SARS-CoV-2) infection unknown, we performed de novo...
Abstract Talaromyces marneffei (TM) immune evasion is an important factor leading to the high mortality rate of Penicilliosis marneffei. N 6 ‐methyladenosine (m A) plays roles in host response various pathogen infections, yet its role TM and HIV/TM coinfection remains largely unexplored. Here we reported genome‐wide transcriptional m A profiles mono‐infection coinfection. Our finding revealed dynamic alterations global levels upregulation reader YTH RNA binding protein C2 (YTHDC2)...
Abstract The risk of severe condition caused by Corona Virus Disease 2019 (COVID-19) increases with age. However, the underlying mechanisms have not been clearly understood. dataset GSE157103 was used to perform weighted gene co-expression network analysis on 100 COVID-19 patients in our analysis. Through analysis, we identified a key module which significantly related This age-related could predict Intensive Care Unit status and mechanical-ventilation usage, enriched positive regulation T...
Gut Universe Database (GutUDB) provides a comprehensive, systematic, and practical platform for researchers, is dedicated to the management, analysis, visualization of knowledge related intestinal diseases. Based on this database, eight major categories omics data analyses are carried out explore genotype-phenotype characteristics certain disease. The first tool comprehensive research diseases will help each researcher better understand intestine serves as central organ in digestive system...
As a key process in transcriptional regulatory mechanisms, alternative splicing (AS) plays crucial role maintaining the diversity of RNA and protein expression, mediates immune response infectious diseases, especially for COVID-19. Therefore, urgent data gathering more research AS profiles microbe-infected human cells are needed to improve understanding COVID-19 related diseases. Herein, we have created CASA, Alternative Splicing Atlas provide convenient computing platform studies...
Dynamic recombination is the driving force in genetic diversity of human immunodeficiency virus type 1 (HIV-1). When multiple subtypes are circulating same area a population, new HIV-1 strains likely to be generated through recombination. In this study, we report novel recombinant strain (2018GXQZLSHET001) HIV-1, isolated from HIV-1-positive heterosexual individual infected Guangdong province, who recently lived Guangxi China. Phylogenetic analysis near full-length genome suggested that...
Innate immunity is the first line of defense against invading pathogens and may mediate HIV-1 resistance in HIV-1-exposed seronegative (HESN) individuals. This study aims to identify components innate that confer natural Chinese HESN Specifically, we compared expression levels Toll-like receptors (TLRs) associated pathway molecules peripheral blood mononuclear cells (PBMCs), monocytes/macrophages, plasma obtained from control individuals had higher TLR9, IRF7, IFN-α/β, RANTES, MIP-1α/1β...
It is widely accepted that N6-methyladenosine (m6A) exhibits significant intercellular specificity, which poses challenges for its detection using existing m6A quantitative methods. In this study, we introduced Single-cell Analysis (Scm6A), a machine learning-based approach single-cell quantification. Scm6A leverages input features derived from the expression levels of trans regulators and cis sequence features, offers remarkable prediction efficiency reliability. To further validate...
Background: Patients with COVID-19 often have an impact on populations underlying co-infection. METTL3 plays a crucial role in numerous infectious diseases, making the research broad-spectrum anti-infective drugs targeting both captivating and compelling. Objective: The study aims to identify anti-infection potential compounds using comprehensive virtual screening approach. Method: approach involves ensemble docking molecular dynamics simulations predict validate of natural compounds. This...
Purpose Immunotherapy using vaccines proved effective for a variety of cancers, however, so far there is no vaccine against many types cancers. The aim this study was to identify potential tumor antigens the development antiall cancer mRNA and map immune landscape pan-cancer select suitable patients vaccination. Methods We collected normalized gene expression data clinical from Chinese Glioma Genome Atlas (CGGA) Cancer (TCGA). Gene Expression Profiling Interactive Analysis (GEPIA) version 2...
Clear cell renal carcinoma (ccRCC) is a major pathological type of kidney cancer with poor prognosis due to lack biomarkers for early diagnosis and prediction ccRCC. In this study, we investigated the aberrant expression Acyl-coenzyme A oxidase 1 (ACOX1) in ccRCC evaluated its potential prognosis. ACOX1 first rate-limiting enzyme peroxidation β-oxidation pathway involved regulation fatty acid oxidative catabolism. The mRNA protein levels were significantly downregulated ccRCC, downregulation...
Introduction K-41A is a known compound with antibacterial activity against gram-positive bacteria and coccidia. In our screening of anti-HIV compounds, we found polyether antibiotic its analogue K-41Am isolated from marine-derived Streptomyces sp. SCSIO 01680 exhibited activity. Material methods this study, characterised the as well mechanism(s) involved. The dose-dependent inhibitory effects on HIV-1 replication were observed in TZM-bl-HIV-1IIIB system, MT-2-HIV-1IIIB peripheral blood...
Abstract As the most abundant mRNA modification in mRNA, N 6 -methyladenosine (m A) plays a crucial role RNA fate, impacting cellular and physiological processes various tumor types. However, our understanding of function m A methylome heterogeneity remains limited. Herein, we collected analyzed methylomes across nine human tissues from 97 A-seq RNA-seq samples. Our findings demonstrate that exhibits different compared to normal tissues, which contributes diverse clinical outcomes cancer We...
Abstract It is widely accepted that m 6 A exhibits significant intercellular specificity, which poses challenges for its detection using existing quantitative methods. In this study, we introduce Scm A, a machine learning-based approach single-cell quantification. leverages input features derived from the expression levels of trans regulators and cis sequence features, found offers remarkable prediction efficiency reliability. To further validate robustness precision applied winscore-based...