A5101404508- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Nanoparticle-Based Drug Delivery
- Cell Image Analysis Techniques
- Pluripotent Stem Cells Research
- Polymer Surface Interaction Studies
- Radiopharmaceutical Chemistry and Applications
- Single-cell and spatial transcriptomics
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Advanced Polymer Synthesis and Characterization
- Thyroid Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Machine Learning and Data Classification
- Prostate Cancer Treatment and Research
- Cell death mechanisms and regulation
- Quinazolinone synthesis and applications
- Boron Compounds in Chemistry
- Connexins and lens biology
- Nitric Oxide and Endothelin Effects
- Genetic Syndromes and Imprinting
Guangxi Medical University
2023-2024
Chifeng University
2023
The University of Tokyo
2023
Tumor Hospital of Guangxi Medical University
2023
Sixth Affiliated Hospital of Sun Yat-sen University
2022
Sun Yat-sen University
2022
Union Hospital
2014-2021
Jilin University
2012-2021
Union Hospital
2013-2021
First Hospital of China Medical University
2012-2020
Identification of induced pluripotent stem (iPS) progenitor cells, the iPS forming cells in early stage reprogramming, could provide valuable information for studying origin and underlying mechanism cells. However, it is very difficult to identify experimentally since there are no biomarkers known only about 6 days after reprogramming initiation, can be determined via fluorescent probes. What more, ratio during reprograming period below 5%, which too low capture stage. In this paper, we...
The aim of this study was to explore the diagnostic performance 99m Tc-3(poly-(ethylene glycol),PEG)4-RGD 2 ( Tc-3PRGD ) scintimammography (SMM) in patients with either palpable or nonpalpable breast lesions and compare SMM mammography assess possible incremental value cancer detection. We also investigated α v β 3 expression malignant benign lesions. Ninety-four 110 were included study. Mammograms evaluated according Breast Imaging Reporting Data System (BI-RADS) by a specialized imaging...
As the most common type of cancer and second leading cause cancer-associated mortality, colorectal (CRC) has received increasing attention. The aim present study was to investigate mechanisms CRC by analyzing microarray dataset, GSE32323. GSE32323 dataset downloaded from Gene Expression Omnibus, included 17 pairs matched normal tissue samples. differentially expressed genes (DEGs) were screened using Linear Models for Microarray Data package a search genes, also denoted as seed performed...
Background: Recent research has revealed a significant association between Anillin (ANLN) and miR-374a‑5p with the progression of tumors. Additionally, bioinformatics analysis indicated an inverse relationship in transcript expression levels ANLN miR-374a-5p. However, specific mechanisms driving miR-374a-5p/ANLN signaling axis oral squamous cell carcinoma (OSCC) have not been thoroughly explored. Methods: were evaluated within OSCC lines tissues by RT-qPCR. Using databases, it demonstrated...
MicroRNAs are known as small, non-coding, and single-stranded RNAs which can regulate cell proliferation, differentiation, apoptosis involve in the development of tumors. In this study, colorectal cancer tissue morphological change different prognosis patients was observed by hematoxylin eosin staining. Thereafter, differentially expressed miR-22 TIAM1 gene were detected using quantitative polymerase chain reaction western blot tissues. Meanwhile, luciferase reporter system used to verify...
Osteosarcoma is a type of malignant bone tumor with high metastasis and poor prognosis. Previous studies have demonstrated the involvement LIM kinase 1 (LIMK1) in proliferation osteosarcoma cells. LIMK1 overexpressed human tissues cell lines. To further study LIMK1-associated mechanisms, we used shRNA targeted to gene block its expression lines MG63 U2OS. Insulin promoted cells time- dose-dependent manner, however, this insulin induced was significantly inhibited by transfection gene, as...
Inorganic nanoparticles play a very important role in the fabrication and regulation of desirable hybrid structures with block copolymers. In this study, polystyrene-b-poly(acrylic acid) (PS48-b-PAA67) oleic acid-capped CdSe/CdS core/shell quantum dots (QDs) are coassembled tetrahydrofuran (THF) through gradual water addition. QDs incorporated into hydrophilic PAA blocks because strong coordination between surface QDs. Increasing weight fraction (ω = 0–0.44) leads to morphological...
5‑Fluorouracil (5‑FU)‑based chemotherapy is the conventional treatment approach for patients with colorectal cancer (CRC). However, <em>de novo</em> and acquired resistance to 5‑FU are frequently observed during treatment, which eventually lead succumbing disease. Accumulating data have revealed an association of CRC aberrant expression microRNAs (miRs). In present study, Cell Counting Kit‑8 was performed measure cell viability, flow cytometry detect apoptosis, reverse...
Erectile dysfunction (ED) is a common sexual problem for men and the exploration of its treatment still in mire demand. We aim to investigate role Toll-like receptor 4 (TLR4)/myeloid differentiation primary response gene 88 (MyD88) signaling pathway pathogenesis angiotensin II (Ang-II) induced ED.Male Sprague-Dawlay rats were treated with Ang-II intracavernous pressure (ICP) was measured confirm occurrence ED. The corpus cavernosum penises transfected plasmids overexpressed MyD88....
Gap junction intercellular communication (GJIC) is important in mediating substance and signal transmission. Connexin (Cx)43 a major component involved GJIC vascular tissue its abnormal expression closely associated with various diseases. Insulin resistance the central of metabolic syndrome, high doses insulin can affect function through multiple pathways, resulting cardiovascular disease. However, effects on connexin smooth muscle cells (VSMCs) remain unclear. Following treatment VSMCs...
Abstract Identification of induced pluripotent stem (iPS) progenitor cells, the iPS forming cells in early stage reprogramming, could provide valuable information for studying origin and underlying mechanism cells. However, it is very difficult to identify experimentally since there are no biomarkers known only about 6 days after reprogramming initiation, can be determined via fluorescent probes. What more, ratio during reprograming period below 5%, which too low capture stage. In this...
Automatic mitosis detection from video is an essential step in analyzing proliferative behaviour of cells. In existing studies, a conventional object detector such as Unet combined with link prediction algorithm to find correspondences between parent and daughter However, they do not take into account the biological constraint that cell frame can correspond up two cells next frame. Our model called GNN-DOL enables by complementing graph neural network (GNN) differentiable optimization layer...