A5100388425- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Wnt/β-catenin signaling in development and cancer
- Drug Solubulity and Delivery Systems
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Digestive system and related health
- Cancer-related gene regulation
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Advanced Drug Delivery Systems
- Crystallization and Solubility Studies
- 3D Printing in Biomedical Research
- Colorectal and Anal Carcinomas
- Advanced Battery Materials and Technologies
- Advanced Memory and Neural Computing
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Pluripotent Stem Cells Research
- Cell Adhesion Molecules Research
- Electrospun Nanofibers in Biomedical Applications
- Neuroscience and Neural Engineering
- RNA Interference and Gene Delivery
Beijing Friendship Hospital
2024-2025
Capital Medical University
2024-2025
China Agricultural University
2013-2025
Duke Kunshan University
2023-2024
University of Bath
2024
Peking University
2012-2024
Peking University People's Hospital
2012-2024
Union Hospital
2024
Hebei Medical University
2024
Huazhong University of Science and Technology
2024
Abstract Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF cells, leading to telogen–anagen transition (TAT) around the wound and de novo regeneration, mostly through TNF signalling. Both knockout overexpression attenuate neogenesis wounds, suggesting dose-dependent induction by TNF, which is consistent with TNF-induced AKT signalling vitro . β-catenin...
All-solid-state batteries (ASSBs) are regarded as the most promising next-generation for electric vehicles in virtue of their potential advantages enhanced safety, high energy density and power capability. Among ASSBs based on various solid electrolytes (SEs), sulfide-based have attracted increasing attention due to ionic conductivity sulfide SEs which is comparable that liquid electrolytes. Extensive efforts from academia industry been made develop ASSBs, several significant progress has...
Type 2 alveolar epithelial cell (AEC2) senescence is crucial to the pathogenesis of pulmonary fibrosis (PF). The nicotinamide adenine dinucleotide (NAD
The MSI2 RNA-binding protein is a potent oncogene playing key roles in haematopoietic stem cell homeostasis and malignant haematopoiesis. Here we demonstrate that expressed the intestinal compartment, its expression elevated colorectal adenocarcinomas, loss-of-function abrogates cancer growth. gain-of-function epithelium drug-inducible mouse model sufficient to phenocopy many of morphological molecular consequences acute loss APC tumour suppressor Wnt-independent manner. Transcriptome-wide...
Abstract Mesenchymal stem cells ( MSC s) hold profound promise in tissue repair/regeneration. However, s undergo remarkable spontaneous differentiation and aging during monolayer culture expansion. In this study, we found that 2–3 days of three‐dimensional (3D) spheroid human (h had been expanded for six passages increased their clonogenicity potency to neuronal cells. Moreover, accordance with these changes, the expression levels mi RNA which were involved cell changed histone H3...
Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells (MSC) trapped lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as cancer-targeted drug delivery vehicles by loading (NP) with anti-cancer drug. showed higher intake capacity than fibroblasts. In addition, predominant trapping both rabbit and monkey. IR-780 dye, fluorescent probe used to represent docetaxel (DTX) NP, delivered
Gliomas are the most common and deadly type of primary brain tumor. In this study, we showed that cAMP response element-binding protein (CREB), a proto-oncogenic transcription factor is overexpressed in gliomas, can promote gliomagenesis by modulating expression oncogenic microRNA-23a (mir-23a). First, found CREB highly expressed glioma tissues cell lines. also essential for growth survival vitro critical vivo. Second, microRNA microarray, ChIP-chip, ChIP-quantitative PCR, luciferase...
Abstract Mesenchymal stem cells (MSCs) are largely entrapped in the lungs after intravenous delivery. The underlying mechanisms have been poorly understood. Flow cytometry and Western blot analysis showed that expression levels of many integrins such as β1, α5, αVβ3 MSCs increased markedly upon cultured expansion 2D monolayers, whose ligands fibronectin vitronectin were detected on surface vascular endothelial by immunostaining flow cytometry. Blockade integrin or with functional blocking...
Members of the Msi family RNA-binding proteins have recently emerged as potent oncoproteins in a range malignancies. MSI2 is highly expressed hematopoietic cancers, where it required for disease maintenance. In contrast to system, colorectal cancers can express both members, MSI1 and MSI2. Here, we demonstrate that, intestinal epithelium, Msi1 Msi2 analogous oncogenic effects. Further, comparison Msi1/2-induced gene expression programs transcriptome-wide analyses Msi1/2-RNA-binding targets...
Abstract Herein, we firstly develop porous organic cage (POC) as an efficient platform for highly effective radioactive iodine capture under industrial operating conditions (typically ≥150 °C), ≤150 ppmv of I 2 ). Due to the dispersed and readily accessible binding sites well sufficient accommodating space, constructed NKPOC‐DT‐(I − ) (NKPOC=Nankai cage) demonstrates a record‐high uptake capacity 48.35 wt % extraordinary adsorption unit ionic site (~1.62) at 150 °C . The is 3.5, 1.6, 1.3...
Abstract Background Breast cancer is the second leading cause of related deaths among females worldwide. Berbamine (BER), a kind bis-benzylisoquinoline alkaloid, has been used to treat clinical patients with inflammation and for many years in China. The purpose this study investigate activity BER against highly-metastatic human breast its molecular mechanisms action. Results In our study, we found that inhibits growth cell lines MDA-MB-231 MDA-MB-435S cells dose-dependently time-dependently....
Abstract Angiopoietin‐2 (Angpt2) plays a critical role in angiogenesis and tumour progression. Therapeutic targeting of Angpt2 has been implicated as promising strategy for cancer treatment. Whereas miRNAs are emerging important modulators angiogenesis, regulation by not established. Here we firstly report that Ang2 is targeted microRNA , miRNA ‐542‐3p, which inhibits progression impairing Ang2's pro‐angiogenic activity. In cultured endothelial cells, miR ‐542‐3p inhibited translation mRNA...
The retention requirements of analog RRAM for neuromorphic computing applications are quite different from conventional memory applications. Meanwhile, filamentary exhibits behavior in comparison to strong-filament RRAM. For the first time, statistical behaviors read current noise and a 1Kb array investigated this work. conductance distribution levels is found change with physical mechanism degradation elucidated. From experimental data, compact model developed order predict evolution, which...
Regeneration of the intestinal epithelium is driven by multiple stem cell (ISC) types, including an active, radiosensitive Wnt
ABSTRACT The EBNA1 protein of Epstein-Barr virus (EBV) is essential for EBV latent infection in ensuring the replication and stable segregation genomes activating transcription other latency genes. We have tested ability four host proteins (Brd2, Brd4, DEK, MeCP2) implicated papillomavirus Kaposi's sarcoma-associated herpesvirus to support EBNA1-mediated EBV-based plasmids Saccharomyces cerevisiae . found that Brd4 enabled while Brd2 MeCP2 had a general stimulatory effect on plasmid...
Sodium lauryl sulfate (SLS), as an effective surfactant, is often used a solubilizer and/or wetting agent in various dosage forms for the purpose of improving solubility and dissolution lipophilic, poorly water-soluble drugs. This study aims to understand impact SLS on solution behavior bioavailability hypromellose acetate succinate (HPMC-AS)-based posaconazole (PSZ) ASDs, identify underlying mechanisms governing optimal oral ASDs when surfactants such are combination. Fluorescence...
The therapeutic effect of mesenchymal stem cells (MSCs) in tissue repair/regeneration is substantially dampened by the loss primitive properties and poor engraftment to target organs. In this study, multipotency cell sizes human MSCs, which had been expanded monolayer culture for several passages, were dramatically restored after an episode three-dimensional (3D) spheroid culture. Unlike MSCs derived from monolayer, caused embolism blindness, 3D spheroids did not cause vascular obstructions,...
Abstract Lgr5 + intestinal stem cells (ISCs) drive the fast renewal of epithelium. Several signaling pathways have been shown to regulate ISC fates. However, it is unclear what are essential signals sustain self-renewal. Here we show that coordination between Wnt and BMP activity necessary sufficient maintain ISCs The key function R-spondin1 achieve a high in organoid culture. Using GSK3 inhibitor CHIR-99021 type I receptor LDN-193189, can without growth factors vitro. Our results define...