A5005882234- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Digestive system and related health
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Evolution and Genetic Dynamics
- Genomics and Phylogenetic Studies
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Laser Applications in Dentistry and Medicine
- Cancer therapeutics and mechanisms
- vaccines and immunoinformatics approaches
- RNA regulation and disease
- Venomous Animal Envenomation and Studies
- Diabetes and associated disorders
- Dietary Effects on Health
- Molecular Biology Techniques and Applications
- Hepatitis B Virus Studies
- Seismic Performance and Analysis
Tehran University of Medical Sciences
2025
Dalhousie University
2025
Stanford University
2020-2023
Stratford University
2022
Kashan University of Medical Sciences
2009-2020
Qom University of Medical Science and Health Services
2020
University of Pennsylvania
2014-2018
University of Zanjan
2018
Shahid Beheshti University of Medical Sciences
2017
Rasool Akram Hospital
2015
The ability to interconvert terminally differentiated cells could serve as a powerful tool for cell-based treatment of degenerative diseases, including diabetes mellitus. To determine which, if any, adult tissues are competent activate an islet β cell program, we performed in vivo screen by expressing three "reprogramming factors" wide spectrum tissues. We report that transient intestinal expression these factors-Pdx1, MafA, and Ngn3 (PMN)-promotes rapid conversion crypt into endocrine...
The MSI2 RNA-binding protein is a potent oncogene playing key roles in haematopoietic stem cell homeostasis and malignant haematopoiesis. Here we demonstrate that expressed the intestinal compartment, its expression elevated colorectal adenocarcinomas, loss-of-function abrogates cancer growth. gain-of-function epithelium drug-inducible mouse model sufficient to phenocopy many of morphological molecular consequences acute loss APC tumour suppressor Wnt-independent manner. Transcriptome-wide...
Members of the Msi family RNA-binding proteins have recently emerged as potent oncoproteins in a range malignancies. MSI2 is highly expressed hematopoietic cancers, where it required for disease maintenance. In contrast to system, colorectal cancers can express both members, MSI1 and MSI2. Here, we demonstrate that, intestinal epithelium, Msi1 Msi2 analogous oncogenic effects. Further, comparison Msi1/2-induced gene expression programs transcriptome-wide analyses Msi1/2-RNA-binding targets...
Phagocytosis is a key macrophage function, but how phagocytosis shapes tumor-associated (TAM) phenotypes and heterogeneity in solid tumors remains unclear. Here, we utilized both syngeneic novel autochthonous lung tumor models which neoplastic cells express the fluorophore tdTomato (tdTom) to identify TAMs that have phagocytosed vivo. Phagocytic tdTompos upregulated antigen presentation anti-inflammatory proteins, downregulated classic proinflammatory effectors compared tdTomneg TAMs....
Highlights•Calorie restriction increases the radioresistant intestinal stem cell (ISC) pool•Calorie suppresses mTORC1 activity in reserve ISCs•Reserve ISC-autonomous governs ISC survival post injury•Calorie-restricted ISCs have enhanced regenerative capacity injurySummaryAging is a complex process associated with decline functionality of adult cells affecting tissue homeostasis and regeneration. Calorie (CR) only experimental manipulation known to extend lifespan reduce incidence age-related...
Regeneration of the intestinal epithelium is driven by multiple stem cell (ISC) types, including an active, radiosensitive Wnt
Cancer genotyping has identified a large number of putative tumor suppressor genes. Carcinogenesis is multistep process, but the importance and specific roles many these genes during initiation, growth, progression remain unknown. Here we use multiplexed mouse model oncogenic KRAS-driven lung cancer to quantify impact 48 known on diverse aspects carcinogenesis at an unprecedented scale resolution. We uncover previously understudied functional suppressors that constrain in vivo. Inactivation...
Abstract The lack of knowledge about the relationship between tumor genotypes and therapeutic responses remains one most critical gaps in enabling effective use cancer therapies. Here, we couple a multiplexed quantitative experimental platform with robust statistical methods to enable pharmacogenomic mapping lung treatment vivo. complex map genotype-specific uncovered that over 20% possible interactions show significant resistance or sensitivity. Known novel were identified, these...
Abstract Lung cancer is the leading cause of death worldwide, with lung adenocarcinoma being most common subtype. Many oncogenes and tumor suppressor genes are altered in this type, discovery oncogene mutations has led to development targeted therapies that have improved clinical outcomes. However, a large fraction adenocarcinomas lacks known oncogenes, genesis treatment these oncogene-negative tumors remain enigmatic. Here, we perform iterative vivo functional screens using quantitative...
Background: Canonical Wnt pathway signaling is necessary for maintaining the proliferative capacity of mammalian intestinal crypt base columnar stem cells (CBCs). Furthermore, dysregulation a major contributor to disease, including oncogenic transformation epithelium. Given critical importance this pathway, numerous tools have been used as proxy measures activity, yet relationship between target gene expression and reporter allele activity within individual at remains unclear. Results: Here,...
Introduction: Pemphigus vulgaris is a chronic blistering skin disease. Management of recalcitrant pemphigus ulcers great problem. Low Level Laser Therapy (LLLT) known to supply direct biostimulative light energy body cells. This study evaluates the efficacy low power laser in healing lesions. Methods: Ten patients with were enrolled trial. The LED-LLLT system used was Thor LED clusters (109, 69 or 19 diode) (England) 660 nm wavelength continuous wave (CW) and 30 mW energy. Both sides...
Cancer genomes are almost invariably complex with genomic alterations cooperating during each step of carcinogenesis. In cancers that lack a single dominant oncogene mutation, cooperation between the inactivation multiple tumor suppressor genes can drive initiation and growth. Here, we shed light on how sequential acquisition generates oncogene-negative lung tumors. We couple barcoding combinatorial multiplexed somatic genome editing to characterize fitness landscapes three NF1, RASA1, PTEN,...
To report a case of perfluorocarbon liquid (PFCL) migration into the subarachnoid space at time vitreoretinal surgery in patient with morning glory syndrome associated retinal detachment. A 9-year-old girl underwent pars plana vitrectomy and silicone oil injection for detachment syndrome. PFCL was used stabilization before endolaser photocoagulation. The retina detached, repeated performed. Postoperative magnetic resonance imaging revealed space. is rare complication patients
A stem cell's epigenome directs cell fate during development, homeostasis, and regeneration. Epigenetic dysregulation can lead to inappropriate decisions, aberrant function, even cancer. The histone variant macroH2A has been shown influence gene expression, guide fate, safeguard against genotoxic stress. Interestingly, mice lacking functional histones (hereafter referred as DKO) are viable fertile; yet suffer from increased perinatal death reduced weight size compared wildtype (WT). Here, we...
<h3>Background</h3> Tumor-associated macrophage (TAMs) are one of the most abundant immune cell types in tumors, and their numbers often inversely correlate with clinical outcome. Phagocytosis is a key function, but how phagocytosis shapes TAM phenotypes heterogeneity solid tumors remains unclear. <h3>Methods</h3> We have utilized both syngeneic novel autochthonous lung tumor models which specifically neoplastic cells express fluorophore tdTomato (tdTom) to identify TAMs that phagocytosed...
In the event of an earthquake, beam-column joints in reinforced concrete moment-resisting frame structures are affected by a high level deformations and stresses. Due to these stresses, joint can be damaged even fractured some cases. The failure cause building collapse. recent years, particular attention has been paid strengthening substandard RC buildings. this paper, is investigated considering nonlinear behavior for steel. For concrete, damage plasticity model reinforcing steels bilinear...
Abstract: The lack of knowledge about the relationship between tumor genotypes and therapeutic responses remains one most important gaps in enabling effective use cancer therapies. Here, we couple a multiplexed quantitative platform with robust statistical methods to enable pharmacogenomic mapping lung treatment vivo . We uncover surprisingly complex map genotype-specific responses, over 20% possible interactions showing significant resistance or sensitivity. validate these - Keap1 mutant...
Adiponectin, an adipocyte-derived protein, modulates a number of metabolic processes. Methadone maintenance treatment (MMT) changes the level hormones produced by adipose tissue in addicts. However, current data remains contradictory.The aim this study was to evaluate effect MMT on serum adiponectin levels drug addicts.Twenty-five abusers with mean age 37.4 ± 8.7 years were referred Baharan Hospital, Zahedan, and 22 healthy age-matched control subjects 35 9.5 enrolled study. Addicts treated...
Cancer genomes are almost invariably complex with genomic alterations cooperating during each step of carcinogenesis. In cancers that lack a single dominant oncogene mutation, cooperation between the inactivation multiple tumor suppressor genes can drive initiation and growth. Here, we shed light on how sequential acquisition generates oncogene-negative lung tumors. We couple barcoding combinatorial multiplexed somatic genome editing to characterize fitness landscapes three NF1, RASA1, PTEN,...