A5005502519- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Industrial Vision Systems and Defect Detection
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Glycosylation and Glycoproteins Research
- Kidney Stones and Urolithiasis Treatments
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Protein Tyrosine Phosphatases
- RNA Research and Splicing
- MicroRNA in disease regulation
- interferon and immune responses
- Epigenetics and DNA Methylation
First Affiliated Hospital of Anhui Medical University
2019-2025
Anhui Medical University
2019-2025
The University of Texas MD Anderson Cancer Center
2018-2025
First Affiliated Hospital of Jiangxi Medical College
2024
Jiangxi Provincial People's Hospital
2024
Chengdu University of Traditional Chinese Medicine
2024
Kunming Medical University
2024
Shantou University
2023
Shantou University Medical College
2023
Peking University Shougang Hospital
2023
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a significant accumulation of fibroblasts as part the host response to cancer. Using single-cell RNA sequencing, multiplex immunostaining, and several genetic mouse models, we identify carcinoma-associated (CAF) with opposing functions PDAC progression. Depletion fibroblast activation protein (FAP)+ CAFs results increased survival, contrast depletion alpha smooth muscle actin (αSMA)+ CAFs, which leads decreased...
The dominant artery blood supply is a characteristic of hepatocellular carcinoma (HCC). However, it not known whether the can predict post-hepatectomy prognosis patients with HCC. This retrospective study investigated prognostic value portal venous and arterial estimated on triphasic liver CT (as coefficient, PVC, hepatic HAC, respectively) in HCC following hepatectomy.
Inflammation and tissue damage associated with pancreatitis can precede or occur concurrently pancreatic ductal adenocarcinoma (PDAC). We demonstrate that in PDAC coupled (ptPDAC), antigen-presenting type I conventional dendritic cells (cDC1s) are specifically activated. Immune checkpoint blockade therapy (iCBT) leads to cytotoxic CD8 + T cell activation elimination of ptPDAC restoration life span even upon rechallenge. Using antigen-loaded cDC1s as a vaccine, immunotherapy-resistant was...
Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions arterial myocytes such as viability, proliferation, apoptosis, survival contraction. The present study tested whether simvastatin, a prototype statin, enhances autophagy in coronary (CAMs) thereby exert beneficial effects atherosclerosis. Methods Results: Using flow cytometry, we demonstrated that simvastatin significantly increased the autophagsome...
Abstract Type I collagen (Col1) is the most abundant protein in mammals. Col1 contributes to 90% of total organic component bone matrix. However, precise cellular origin and functional contribution embryogenesis formation remain unknown. Single-cell RNA-sequencing analysis identifies Fap + cells Fsp1 as major contributors bone. We generate transgenic mouse models genetically delete various cell lineages. Complete, whole-body deletion leads failed gastrulation early embryonic lethality....
Abstract Hepatocellular carcinoma (HCC) is a form of malignancy with limited curative options available. To improve therapeutic outcomes, it imperative to develop novel, potent modalities. Ketoconazole (KET) has shown excellent efficacy against HCC by eliciting apoptosis. However, its water solubility hampers application in clinical treatment. Herein, mitochondria‐targeted chemo‐photodynamic nanoplatform, CS@KET/P780 NPs, designed using nanoprecipitation strategy integrating newly...
Metabolic reprogramming is a hallmark of cancer. Stromal cells could function as providers energy metabolites for tumor by undergoing the "reverse Warburg effect," but mechanism has not been fully elucidated. The interaction between tumoral microvesicles (TMVs) and stroma in microenvironment plays critical role facilitating cancer progression. In this study, we demonstrated novel TMV-mediated glycometabolic stromal cells. After being incubated with TMVs, normal human gingival fibroblasts...
Research Article17 August 2018Open Access Source DataTransparent process Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program Yang Chen Department Cancer Biology, Metastasis Center, University Texas MD Anderson Houston, TX, USA Search for more papers by this author Valerie S LeBleu Julienne L Carstens Hikaru Sugimoto Xiaofeng Zheng Shruti Malasi Dieter Saur Medicine II Klinikum rechts der Isar, Technische...
Abstract Cancer metastasis poses significant challenges in current clinical therapy. Osthole (OST) has demonstrated efficacy treating cervical cancer and inhibiting metastasis. Despite these positive results, its limited solubility, poor oral absorption, low bioavailability, photosensitivity hinder application. To address this limitation, a glutathione (GSH)‐responded nano‐herb delivery system (HA/MOS@OST&L‐Arg nanoparticles, HMOA NPs) is devised for the targeted of OST with...
Abstract Background Increasing evidence indicates that the tumor microenvironment (TME) is a crucial determinant of cancer progression. However, clinical and pathobiological significance stromal signatures in TME, as complex dynamic entity, still unclear esophageal squamous cell carcinoma (ESCC). Methods Herein, we used single-cell transcriptome sequencing data, imaging mass cytometry (IMC) multiplex immunofluorescence staining to characterize ESCC evaluate their prognostic values this...
Cetuximab, a monoclonal antibody (mAb) targeting the epidermal growth factor receptor (EGFR), has been intensively investigated as promising cancer treatment strategy. The specific mechanism of cetuximab endocytosis and its influence on uptake, biodistribution efficacy still remain elusive. Recently, statins have reported to synergize with EGFR-targeting agents. Our prior work established that nystatin, cholesterol-sequestering antifungal drug, facilitates via clathrin-dependent pathway....
Endostatin is a well-known angiogenesis inhibitor. Although has been considered as potential therapeutic target of obesity, the inhibitory effect endostatin on adipogenesis and dietary-induced obesity never demonstrated. Adipogenesis plays critical role in controlling adipocyte cell number, body weight, metabolic profile homeostatic state. Here we reveal that inhibits obesity. The antiadipogenic mechanism lies its interaction with Sam68 RNA-binding protein nuclei preadipocytes. This...