A5102748200- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Esophageal Cancer Research and Treatment
- Liver physiology and pathology
- Mesenchymal stem cell research
- Connective Tissue Growth Factor Research
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Glioma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Dental Implant Techniques and Outcomes
- Single-cell and spatial transcriptomics
- Photodynamic Therapy Research Studies
- Biomarkers in Disease Mechanisms
- Streptococcal Infections and Treatments
- Peptidase Inhibition and Analysis
- Digital Imaging in Medicine
- Body Image and Dysmorphia Studies
- Spinal Dysraphism and Malformations
- Reconstructive Facial Surgery Techniques
- Forensic and Genetic Research
- Kruppel-like factors research
Sun Yat-sen University
2025
Tianjin Medical University Cancer Institute and Hospital
2017-2024
Shantou University
2010-2024
Shantou University Medical College
2019-2024
Nantong University
2012-2023
Shanghai Jiao Tong University
2011-2023
Shanghai Ninth People's Hospital
2011-2023
Affiliated Hospital of Nantong University
2012-2023
National Clinical Research Center for Digestive Diseases
2023
First Affiliated Hospital of GuangXi Medical University
2022
Abstract The tumor microenvironment is a highly complex ecosystem of diverse cell types, which shape cancer biology and impact the responsiveness to therapy. Here, we analyze esophageal squamous carcinoma (ESCC) using single-cell transcriptome sequencing in 62,161 cells from blood, adjacent nonmalignant matched samples 11 ESCC patients. We uncover heterogeneity most types stroma, particularly fibroblast immune compartments. identify tumor-specific subset CST1 + myofibroblasts with prognostic...
Abstract Esophageal cancer (EC) is a type of aggressive without clinically relevant molecular subtypes, hindering the development effective strategies for treatment. To define subtypes EC, we perform mass spectrometry-based proteomic and phosphoproteomics profiling EC tumors adjacent non-tumor tissues, revealing catalog proteins phosphosites that are dysregulated in ECs. The cohort stratified into two subtypes—S1 S2—based on analysis, with S2 subtype characterized by upregulation...
Abstract Background Increasing evidence indicates that the tumor microenvironment (TME) is a crucial determinant of cancer progression. However, clinical and pathobiological significance stromal signatures in TME, as complex dynamic entity, still unclear esophageal squamous cell carcinoma (ESCC). Methods Herein, we used single-cell transcriptome sequencing data, imaging mass cytometry (IMC) multiplex immunofluorescence staining to characterize ESCC evaluate their prognostic values this...
Fascin actin-bundling protein 1 (Fascin) is highly expressed in a variety of cancers, including esophageal squamous cell carcinoma (ESCC), working as an important oncogenic and promoting the migration invasion cancer cells by bundling F-actin to facilitate formation filopodia invadopodia. However, it not clear how exactly function regulated acetylation cells. Here, ESCC cells, histone acetyltransferase KAT8 catalyzed lysine 41 (K41) acetylation, inhibit Fascin-mediated Furthermore,...
Objective: To investigate the fit of dust-exposed workers wearing KN95 masks in a city Guangdong Province, and to discuss intervention effect nose pads elastic adjustment clasps on masks. Methods: In January 2024, 145 from stone processing enterprise Province were selected as study subjects by convenience sampling, 4 types commonly used test The head face dimensions measured using right-angle gauge curved-angle gauge, factor (FF) was tested quantitative for respiratory protective equipment,...
Abstract Our recent studies identified the cell surface protein IL-1 receptor accessory (IL1RAP) as a crucial regulator of redox homeostasis and suppressor ferroptosis (iron-mediated death) in Ewing sarcoma (EwS). IL1RAP directly binds to CD98/xCT plasma membrane antiporter enhance cystine uptake, thereby replenishing cysteine glutathione (GSH) pools EwS cells. Moreover, when extracellular is limited, induces cystathionine gamma lyase (CTH) activate transsulfuration (TSS) pathway for de novo...
Nuclear factor of activated T cells 45 kDa (NF45), is a transcription that interacts with NF90 to regulate gene expression. It has been proved be associated tumor proliferation in various human malignancies. However, the role NF45 glioma poorly understood. The aim our study was examine relationship between expression and pathological grade impact on cells. Expression levels are significantly elevated high-grade tissue samples compared low-grade tissues (P < 0.0001) Western blot analysis....
Aim To investigate the differentiation potential of human umbilical mesenchymal stem cells (HuMSCs) and key factors that facilitate hepatic differentiation. Methods HuMSCs were induced to become hepatocyte-like according a previously published protocol. The status was examined by observing morphological changes under an inverted microscope immunofluorescence analysis. Hepatocyte nuclear factor 4 alpha (HNF4α) overexpression achieved plasmid transfection cells. expression proteins genes...
The subgingival microbial ecology is complex, and little known regarding its bacteria species composition in healthy Chinese individuals. This study aimed to identify the microbiota from 6 subjects. Subgingival samples volunteers were collected, 16S rRNA gene was amplified using broad-range bacterial primers, clone libraries constructed. For initial 2,439 sequences analyzed, 383 species-level operational taxonomic units (SLOTUs) belonging seven phyla identified, estimated as 51% [95%...
Abstract Purpose To analyze the mutational landscape of pan-cancer patients with PIK3CA mutations in Chinese population real-world. Methods We analyzed mutation status sequencing data cell-free DNA from plasma and genomic matched peripheral blood lymphocyte 11,904 patients, compared them Catalogue Somatic Mutations Cancer (COSMIC) database. Besides, concomitant aberrations -mutated samples were detected to investigate cancer driver genes, as well their enriched pathways. Meanwhile, Alpelisib...
Acellular Bovine Pericardium Matrix (ABPM) is a new material in implant-based breast reconstruction (IBBR). Few studies have reported on its outcome and complications worldwide most were without control group. Our aim was to compare use IBBR with the other two conventional methods.A retrospective review of patients undergoing from January December 2018 performed. Patients assigned ABPM-assisted (group A), latissimus dorsi-assisted B) two-stage C). Patients' post-operative complications,...
The number of immediate breast reconstruction (IBR) procedures has been increasing in China. This study aimed to investigate the oncological safety IBR, and compare survival surgical outcomes between implant-based autologous reconstruction.Data from patients diagnosed with invasive cancer who underwent total 2001 2016 were retrospectively reviewed. Long-term cancer-specific (BCSS), disease-free (DFS), locoregional recurrence-free (LRFS) evaluated. Patient satisfaction was compared groups....
Connective tissue growth factor (CTGF, CCN2), a secreted protein, is involved in the development and progression of esophageal squamous cell carcinoma (ESCC). However, it remains unclear how CTGF expression affects ESCC. Our study implicated differences protein status precancerous lesions, retrospectively examined associations mRNA levels with clinical prognosis ESCC patients. Here immunohistochemistry quantitative real-time reverse transcription polymerase were performed for predicting...
Immediate postmastectomy breast reconstruction (IPBR) has gained wide popularity in China. We sought to clarify the prevalence and predictors of implant-based vs autologous IPBR among Chinese patients.A retrospective cohort study was performed using a prospectively maintained database. Women who underwent during 2001-2017 were included. The modality-specific trends deciphered by curve fitting analysis. association sociodemographic oncological features with decision for investigated...
Breast reconstruction for Chinese patients is vastly different given cultural differences, patient preferences, access to resources, and insurance coverage in China. Given these unique factors, a approach optimizing outcomes should be considered.Retrospective review of all undergoing implant-based breast from January 2013 May 2016 was performed. Esthetic evaluations were made both by the 1 nonoperative surgeon at least 6 months postoperative, satisfaction assessed using Breast-Q.Overall, 135...
Dysplasia and intramucosal esophageal squamous cell carcinoma (ESCC) frequently go unnoticed with white-light endoscopy and, therefore, progress to invasive tumors. If suitable targets are available, fluorescence molecular might be promising improve early detection. Microarray expression data of patient-derived normal esophagus (n = 120) ESCC samples 118) were analyzed by functional genomic mRNA (FGmRNA) profiling predict target upregulation on protein levels. The predicted top 60...
A 20-year-old man presented with a 1-month history of increasing right leg weakness and numbness. There was spinal enhancing mass from C4 distally ([figure 1][1], A–C) intracranial dissemination 2][2], B). The patient underwent 1-stage resection to the greatest extent