A5102862889- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Digestive system and related health
- NF-κB Signaling Pathways
- Receptor Mechanisms and Signaling
- Hippo pathway signaling and YAP/TAZ
- Immune Response and Inflammation
- TGF-β signaling in diseases
- Ginseng Biological Effects and Applications
- Chemical Synthesis and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Kruppel-like factors research
- Brain Metastases and Treatment
- Sepsis Diagnosis and Treatment
- Iron Metabolism and Disorders
- Endoplasmic Reticulum Stress and Disease
- Inflammasome and immune disorders
- Bioactive natural compounds
- Cancer, Stress, Anesthesia, and Immune Response
- Phytochemical and Pharmacological Studies
- FOXO transcription factor regulation
- Traditional Chinese Medicine Analysis
Northwest Normal University
2021-2025
National Institute of Biological Sciences, Beijing
2021-2024
Center for Life Sciences
2015-2024
Tsinghua University
2011-2024
Chinese Academy of Sciences
2023
Center for Excellence in Molecular Cell Science
2018-2023
Tianjin Medical University
2023
University of Chinese Academy of Sciences
2018
Abstract The intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by actively proliferating Lgr5 + stem cells. Bone morphogenetic protein (BMP) signalling represents one major counterforce that limits the hyperproliferation of epithelium, but exact mechanism remains elusive. Here we demonstrate epithelial BMP plays an indispensable role in restricting cell expansion to maintain homeostasis and prevent premalignant on damage. Mechanistically, inhibits stemness...
Transforming growth factor beta (TGF-β), a multifunctional cytokine, plays critical roles in immune responses. However, the precise role of TGF-β colitis and colitis-associated cancer remains poorly defined. Here, it is demonstrated that promotes colonic inflammation related tumorigenesis absence Smad family member 4 (Smad4). Smad4 loss intestinal epithelium aggravates neoplasia induced by dextran sulfate sodium (DSS) azoxymethane/dextran (AOM/DSS), leading to over-activated responses...
Lgr5+ stem cells are crucial to gut epithelium homeostasis, and therapies targeting these hold promise for treatment of gastrointestinal diseases. Here we report that the non-muscle-myosin-II (NMII) heavy chain Myh9 accumulates at epithelial injury sites in mice distal colon treated with dextran sulphate sodium (DSS). Gut-epithelium-specific monoallelic deletion alleviates DSS-induced colonic crypt damage acute colitis. Consistently, NMII inhibitor blebbistatin can improve survival growth...
An alternative all-hydrocarbon stapling approach in which the amino acid side chains are retained at stapled positions.
Abstract Lgr5 + intestinal stem cells (ISCs) drive the fast renewal of epithelium. Several signaling pathways have been shown to regulate ISC fates. However, it is unclear what are essential signals sustain self-renewal. Here we show that coordination between Wnt and BMP activity necessary sufficient maintain ISCs The key function R-spondin1 achieve a high in organoid culture. Using GSK3 inhibitor CHIR-99021 type I receptor LDN-193189, can without growth factors vitro. Our results define...
Rationale: Sepsis is a potentially life-threatening condition caused by the body's response to severe infection.Although identification of multiple pathways involved in inflammation, tissue damage and aberrant healing during sepsis, there remain unmet needs for development new therapeutic strategies essential prevent reoccurrence infection organ injuries.Methods: Expression Suppressor Fused (Sufu) was evaluated qRT-PCR, western blotting, immunofluorescence murine lung peritoneal...
G-protein coupled receptors (GPCRs) are recognized as attractive targets for drug therapy. However, it remains poorly understood how GPCRs, except a few chemokine receptors, regulate the progression of liver fibrosis. Here, we aimed to reveal role GPR65, proton-sensing receptor, in fibrosis and elucidate underlying mechanism. The expression level GPR65 was evaluated both human mouse fibrotic livers. Furthermore, Gpr65-deficient mice were treated with either bile duct ligation (BDL) 21 d or...
Highlights•Upon DNA damage, ATM activates TGF-β signaling by stabilizing the receptor TβRII•ATM phosphorylates and stabilizes c-Cbl, which enhances TβRII neddylation•DNA damage interaction among ATM, TβRII•The ATM-c-Cbl-TβRII axis plays a pivotal role in intestinal regenerationSummaryActivation of both response (DDR) transforming growth factor β (TGF-β) induces arrest most cell types. However, it is unclear whether DDR that turn contributes to arrest. Here, we show ataxia telangiectasia...
Isorhamnetin (ISO), a naturally occurring plant flavonoid, is widely used as phytomedicine. The major treatment modality for non-small-cell lung carcinoma (NSCLC) radiotherapy. However, radiotherapy can induce radioresistance in cancer cells, thereby resulting poor response rate. Our results demonstrated that pretreatment with ISO induced radiosensitizing effect A549 cells using colony formation, micronucleus, and γH2AX foci assays. In addition, significantly enhanced the radiation-induced...
Adiponectin physically interacts with by comigration in gel electrophoresis (View Interaction 1, 2) cosedimentation through density gradient interaction)
Colorectal cancer (CRC) is one of the most common cancers, but mechanisms underlying its initiation and progression are largely unknown. TGIF1 (TGFB induced factor homeobox 1) a transcriptional corepressor that belongs to three-amino acid loop extension (TALE) superclass atypical homeodomains. It has been reported highly expressed in mammary non-small cell lung can enhance tumor progression. However, role colorectal remains Here, we report significantly upregulated high expression predicts...
Significance We have discovered that the ventrolateral medulla (VLM) catecholaminergic (CA) neurons, a group of neurons control mouse stress response, are activated in tumor-bearing mice, and neuronal activity promotes tumor growth multiple syngeneic spontaneous models. The tumor-promoting effect these VLM CA is mediated by cytotoxic T cells. These findings establish an interaction between brain influences tumorigenesis modulating adaptive immunity.
Hepatic fibrosis is a common consequence of chronic liver diseases without approved antifibrotic therapies. Long noncoding RNAs (lncRNAs) play an important role in various pathophysiological processes. However, the functions certain lncRNAs involved mediating remain largely unclear.The RNA level lnc-High Expressed Liver Fibrosis (Helf) was detected both mouse and human fibrotic livers. Furthermore, lnc-Helf-silenced mice were treated with carbon tetrachloride (CCl4) or bile duct ligation...
Lgr5+ intestinal stem cells are crucial for fast homeostatic renewal of epithelium and Wnt/β-catenin signaling plays an essential role in this process by sustaining cell self-renewal. The poly(ADP-ribose) polymerases tankyrases (TNKSs) mediate protein poly-ADP-ribosylation involved multiple cellular processes such as Wnt regulation, mitotic progression telomere maintenance. However, little is known about the physiological function TNKSs homeostasis regulation. Here, using...
Non-muscle myosin IIA plays an important role in cell adhesion, migration, and tissue architecture. We previously showed that low activity of the heavy chain non-muscle II Myh9 is beneficial to LGR5+ intestinal stem maintenance. However, function adult mouse epithelium largely unclear. In this study, we used inducible Villin-creERT2 knockout approach delete observed homozygous deletion causes colitis-like morphologic changes intestine, leads a high sensitivity dextran sulfate sodium promotes...
Sepsis is a complex syndrome resulting from an aberrant host response to infection. A hallmark of sepsis the failure immune system restore balance. Despite efforts clear pathogens, inflammatory persists, leading persistent inflammation. This chronic inflammation can contribute additional tissue damage and organ dysfunction. Moreover, immunosuppression in render patients more susceptible secondary infections, further complicating clinical course disease. The pathophysiology involves various...