A5063547512- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Protein Hydrolysis and Bioactive Peptides
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Antimicrobial Peptides and Activities
- Polyamine Metabolism and Applications
- Hippo pathway signaling and YAP/TAZ
- Fibroblast Growth Factor Research
- Pancreatic and Hepatic Oncology Research
Tsinghua University
2022-2025
Center for Life Sciences
2022-2025
Transforming growth factor beta (TGF-β), a multifunctional cytokine, plays critical roles in immune responses. However, the precise role of TGF-β colitis and colitis-associated cancer remains poorly defined. Here, it is demonstrated that promotes colonic inflammation related tumorigenesis absence Smad family member 4 (Smad4). Smad4 loss intestinal epithelium aggravates neoplasia induced by dextran sulfate sodium (DSS) azoxymethane/dextran (AOM/DSS), leading to over-activated responses...
Epithelial-mesenchymal transition (EMT) is a highly dynamic cellular process that occurs in development, tissue repair and cancer metastasis. As master EMT inducer, TGF-β can activate the program by regulating expression of key EMT-related genes triggering other required changes. However, it unclear whether cell metabolism involved TGF-β-induced EMT. Here, we characterized early metabolic changes response to transient stimulation HaCaT cells discovered signaling significantly reduces...
Transforming growth factor β (TGF-β) and HER2 signaling collaborate to promote breast cancer progression. However, their molecular interplay is largely unclear. TGF-β can activate mitogen-activated protein kinase (MAPK) AKT, but the underlying mechanism not fully understood. In this study, we report that enhances activation, leading activation of MAPK AKT. This process depends on type I receptor TβRI activity. phosphorylates at Ser779, promoting Y1248 phosphorylation activation. Mice with...
Paracrine signals play pivotal roles in organ homeostasis. Mesenchymal stromal cells (MSCs) a key role regulating epithelium homeostasis the intestine while their paracrine effects are poorly characterized. Here, we identified prostaglandin E2 (PGE2) secreted by cyclooxygenase (COX)-expressing MSCs as vital factor to maintain intestinal mucosal barrier. We found that MSCs-induced organoid swelling through effect vitro, process due enhanced water adsorption and is mediated COX-PGE2-EP4 axis....