A5100744972- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Reproductive Biology and Fertility
- Hepatitis Viruses Studies and Epidemiology
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- Tracheal and airway disorders
- Cellular transport and secretion
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Digestive system and related health
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Recommender Systems and Techniques
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- TGF-β signaling in diseases
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Advanced Bandit Algorithms Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Chinese Academy of Sciences
2014-2023
Center for Life Sciences
2019-2023
Tsinghua University
2019-2023
University of Chinese Academy of Sciences
2017-2023
Guangzhou Institutes of Biomedicine and Health
2022-2023
Capital Medical University
2017-2023
China Electronics Standardization Institute
2023
Nanjing Municipal Center for Disease Control And Prevention
2007-2023
Shenzhen Institutes of Advanced Technology
2023
The intestine plays an important role in nutrient digestion and absorption, microbe defense, hormone secretion. Although major cell types have been identified the mouse intestinal epithelium, type–specific markers functional assignments are largely unavailable for human intestine. Here, our single-cell RNA-seq analyses of 14,537 epithelial cells from ileum, colon, rectum reveal different absorption preferences small large intestine, suggest existence Paneth-like identify potential new marker...
Immune checkpoint inhibitors against PD-1/PD-L1 yield improved survival rates of KRAS-mutant NSCLC patients, who conferred a poor prognosis without effective targeted therapy until now. Yet, the underlying association between KRAS mutations and immune responses remains unclear. We performed an integrated analysis data from publicly available repositories clinical center cohorts to explore mutation status tumor immunity-associated features, including PD-L1 expression, CD8+ tumor-infiltrating...
Aberrant activation of Wnt/β-catenin signaling has been associated with the onset and progression many types tumors thus β-catenin represents one attractive intracellular target for cancer therapy. Based on Axin-derived peptide that binds to β-catenin, two stapled peptides SAHPA1 xStAx were reported enhance or impair signaling, respectively. In this study, we designed PROTACs (proteolysis targeting chimeras) by coupling VHL ligand achieve efficient degradation. The obtained xStAx-VHLL...
Background/Aims: Diabetic cardiomyopathy (DCM) represents the major cause of morbidity and mortality among diabetics. Exercise has been reported to be effective protect heart from cardiac injury during development DCM. However, potential cardioprotective effect exercise in advanced DCM remains unclear. Methods: Seven-week old male C57BL/6 wild-type or db/db mice were either subjected a running program for 15 weeks kept sedentary. Cardiac function, myocardial apoptosis fibrosis, mitochondrial...
Both explicit and implicit feedbacks can reflect user opinions on items, which are essential for learning preferences in recommendation. However, most current recommendation algorithms merely focus positive (e.g., click), ignoring other informative behaviors. In this paper, we aim to jointly consider explicit/implicit positive/negative learn unbiased Specifically, propose a novel Deep feedback network (DFN) modeling click, unclick dislike DFN has an internal interaction component that...
Li metal has been considered as the ultimate anode material for high-density electrochemical energy storage technology because of its extremely high specific capacity (3860 mAh g<sup>−1</sup>), lowest redox potential, and ability to enable battery chemistries with lithium free cathode materials.
Transforming growth factor beta (TGF-β), a multifunctional cytokine, plays critical roles in immune responses. However, the precise role of TGF-β colitis and colitis-associated cancer remains poorly defined. Here, it is demonstrated that promotes colonic inflammation related tumorigenesis absence Smad family member 4 (Smad4). Smad4 loss intestinal epithelium aggravates neoplasia induced by dextran sulfate sodium (DSS) azoxymethane/dextran (AOM/DSS), leading to over-activated responses...
Fine particulate matter (PM2.5) has an adverse effect on reproductive function, in particular causing reduced male but relatively few studies have directly targeted its effects female reproduction. To investigate the of PM2.5 exposure reproduction, we exposed mice to by intratracheal instillation for 28 days, and evaluated apoptosis ovarian granulosa cells oocytes quality embryos after insemination. Our results showed increased numbers apoptotic elevated concentrations PM2.5, which had...
Abstract Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here, we perform multi-omics analysis 56 PSC samples, 14 which are microdissected to analyze intratumoral heterogeneity. We report the mutational landscape PSC. The epithelial and components share numerous genomic alterations, indicating common progenitor. find that epithelial-mesenchymal transition (EMT) plays important roles in carcinogenesis pan-cancer reveals high tumor mutation burden...
Mancozeb, a mixture of ethylene-bis-dithiocarbamate manganese and zinc salts, is one the most widely used fungicides in agriculture. Mancozeb could lead to mitochondria dysfunction, cellular anti-oxidation enzymes depletion apoptotic pathways activation. Previous studies indicated exposure mancozeb through mother would irregular estrous cycles, decreased progesterone levels, reduced litter sizes, more frequent delivery dead fetuses. In this study, we investigated inducing reproductive...
Animal models are widely used for biomedical studies and drug evaluation. The small intestine plays key roles in nutrient absorption, hormone secretion, microbiota defense absorption metabolism. Although the intestinal structure of mammals is conserved, differences on epithelial cell composition, functional assignments among largely unknown. Here, cross-species analysis single-cell transcriptomic atlas ileum epithelium from mouse, rat, pig, macaque human reveals conserved differential types...
An effective online recommendation system should jointly capture users' long-term and short-term preferences in both internal behaviors (from the target task) external other tasks). However, it is extremely challenging to conduct fast adaptations real-time new trends while making full use of all historical large-scale systems, due real-world limitations training efficiency behavior acquisition. To address these practical challenges, we propose a novel Long Short-Term Temporal Meta-learning...
Cytokine secretion and phagocytosis are key functions of activated microglia. However, the molecular mechanisms underlying their regulation in microglia remain largely unknown. Here, we report that synaptotagmin-11 (Syt11), a non-Ca2+ -binding Syt implicated Parkinson disease schizophrenia, inhibits cytokine We found Syt11 expression brain slices primary Interestingly, Syt11-knockdown (KD) increased NO release both absence presence lipopolysaccharide. NF-κB was untreated KD together with...
Background: The identification of prognostic markers for non-small-cell lung carcinoma (NSCLC) is needed clinical practice. metabolism-reprogramming marker ketohexokinase (KHK)-A and acetyl-CoA synthetase 2 (ACSS2) phosphorylation at S659 (ACSS2 pS659) play important roles in tumorigenesis tumor development. However, the significance KHK-A ACSS2 pS659 NSCLC largely unknown. Methods: expression levels were assessed by immunohistochemistry analyses surgical specimens from 303 patients. values...
Bone morphogenic protein (BMP) signaling is critical for intestinal development, homeostasis, and function performance. Although the of BMP in epithelium well appreciated, direct effect on stromal cells poorly understood. Here, we show that disruption by genetic ablation Alk3 or Smad4 expands cell pool, mucosa tumefaction, colonic polyposis large intestine. Interleukin (IL) secretion notably increased, including IL-1, IL-11, IL-17. Specifically, IL-1 IL-17a hyperactivate mucin production...
Background Cortical neurons implement a high frequency-specific modulation of subcortical nuclei that includes the cochlear nucleus. Anatomical studies show corticofugal fibers terminating in auditory thalamus and midbrain are mostly ipsilateral. Differently, nucleus bilateral, which fits to needs binaural hearing improves quality. This leads our hypothesis initial neural processing sound information from contralateral ipsilateral ears could be equivalent or coordinated at first level....
Background: Pulmonary neuroendocrine tumors (PNETs) are a special subtype of lung cancer with treatment methods limited and prognostic indicators insufficient. The preoperative systemic immune-inflammation index (SII) nutritional (PNI) effective tumor biomarkers that have important significance for the prognosis many malignant tumors. However, there is no similar research on predictive value SII PNI operable PNETs. Our study aimed to clarify in PNETs patients after surgical resection.