A5100658575- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and characterization of novel inorganic/organometallic compounds
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Catalytic Cross-Coupling Reactions
- Tuberculosis Research and Epidemiology
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Organometallic Complex Synthesis and Catalysis
- Organoboron and organosilicon chemistry
- Synthetic Organic Chemistry Methods
- Coordination Chemistry and Organometallics
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Pleural and Pulmonary Diseases
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Food Quality and Safety Studies
- Asymmetric Hydrogenation and Catalysis
- Chromatography in Natural Products
Southern University of Science and Technology
2019-2025
Beijing Friendship Hospital
2024-2025
Capital Medical University
2024-2025
Fudan University
2024
Sun Yat-sen University
2014-2024
Tianjin University of Traditional Chinese Medicine
2022-2024
Shanxi Medical University
2024
Sun Yat-sen Memorial Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2023
Nantong University
2009-2023
Immune checkpoint inhibitors against PD-1/PD-L1 yield improved survival rates of KRAS-mutant NSCLC patients, who conferred a poor prognosis without effective targeted therapy until now. Yet, the underlying association between KRAS mutations and immune responses remains unclear. We performed an integrated analysis data from publicly available repositories clinical center cohorts to explore mutation status tumor immunity-associated features, including PD-L1 expression, CD8+ tumor-infiltrating...
Abstract Background Although immune checkpoint inhibitors (ICIs) against programmed cell death protein 1 (PD‐1) and its ligand PD‐L1 have demonstrated potency towards treating patients with non‐small lung carcinoma (NSCLC), the potential association between Kirsten rat sarcoma viral oncogene homolog ( KRAS ) substitutions efficacy of ICIs remains unclear. In this study, we aimed to find point mutations in gene resistant elucidate resistance mechanism. Methods The variant status was explored...
Isolable singlet carbenes have universally adopted a σ
The goal of this study was to investigate the role platelets in systemic and cardiac inflammatory responses development postinfarct ventricular complications, as well efficacy antiplatelet interventions.Using a mouse myocardial infarction (MI) model, we determined platelet accumulation severity inflammation within infarcted myocardium by immunohistochemistry biochemical assays, analyzed peripheral blood platelet-leukocyte conjugation using flow cytometry, tested interventions, including...
Taxol is one of the most famous natural diterpenoids and an important anticancer medicine. represents a formidable synthetic challenge has prompted significant interest from community. However, in all previous syntheses Taxol, there have been no reports closing desired eight-membered ring through C1–C2 bond formation. Furthermore, existence Taxol-resistant tumors side effects make development new approaches to synthesize its derivatives highly desirable. Here, we report asymmetric total...
Under an atmosphere of carbon monoxide (CO), a (phosphino)diazomethyl anion salt [[P]-CN2 ][K(18-C-6)(THF)] (1) ([P]=[(CH2 )(NDipp)]2 P; 18-C-6=18-crown-6; Dipp=2,6-diisopropylphenyl) undergoes facile N2 /CO exchange reaction giving the (phosphino)ketenyl [[P]-CCO][K(18-C-6)] (2). Oxidation 2 with elemental Se affords (selenophosphoryl)ketenyl [P](Se)-CCO][K(18-C-6)] (3). These ketenyl anions feature strongly bent geometry at P-bound and this atom is highly nucleophilic. The electronic...
Determination of the cause malignant pleural effusions is important for treatment and management, especially in cases unknown primaries. There are limited biomarkers available prediction effusion clinical practice. Hence, we evaluated levels five tumor (CEA, AFP, CA125, CA153 CA199) predicting a retrospective study. Kruskal-Wallis or Mann-Whitney U tests were carried out to compare markers among different forms neoplasia - lung squamous cell carcinoma, adenocarcinoma, small mesothelioma,...
<h3>Objective:</h3> The aim of this study was to investigate how the tumor immune microenvironment differs regarding genomics, as well its impact on prognoses and responses immunotherapy in East Asian patients with non-small cell lung cancer (NSCLC). <h3>Methods:</h3> We performed an integrated analysis using publicly available data identify associations between anti-programmed death 1 (PD-1)/ programmed death-ligand (PD-L1) efficacy classic driver oncogene mutations NSCLC patients. Four...
Abstract Background Multimorbidity, body pain, sleep disturbance, and depression are major clinical public health challenges. This paper aimed to examine the associations of multimorbidity with duration, depression; whether varied by socioeconomic status. Methods Data was derived from four waves nationally representative China Health Retirement Longitudinal Study (CHARLS), including participants aged 45 years older in 2011. 12 physical non-communicable diseases 1 mental chronic disease were...
ConspectusThe advancement of synthetic methodologies is fundamentally driven by a deeper understanding the structure–reactivity relationships reactive key intermediates. Carbyne anions are compounds featuring monovalent anionic carbon possessing four nonbonding valence electrons, which were historically confined to theoretical constructs or observed solely within environment gas-phase studies. These species possess potential for applications across diverse domains chemistry and ancillary...
Background and Purpose Nuciferine, a constituent of lotus leaf, is an aromatic ring‐containing alkaloid, with antioxidative properties. We hypothesize nuciferine might affect vascular reactivity. This study aimed at determining the effects on vasomotor tone underlying mechanism Experimental Approach Nuciferine‐induced relaxations in rings rat main mesenteric arteries were measured by wire myographs. Endothelial NOS ( eNOS ) was determined immunoblotting. Intracellular NO production HUVECs Ca...
Objectives: Although low-dose computed tomography has been confirmed to have meaningful diagnostic utility, lung cancer is still the leading cause of cancer-related deaths for both genders worldwide. Thus, a novel panel with stronger performance needed. This study aimed investigate efficacy new in diagnosis.Materials and Methods: The serum levels carcinoembryonic antigen (CEA), 125 (CA125) seven autoantibodies were measured statistically analyzed samples from healthy controls patients...
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases (CVDs). Stachydrine (STA) active component in Chinese motherwort Leonurus heterophyllus sweet, which has been widely used gynecological and disorders. This study aimed to examine the effects of STA on homocysteine (Hcy)-induced endothelial dysfunction.The vascular relaxation rat thoracic aortas (TA), mesenteric arteries (MA) renal (RA) were measured by using Multi Myograph System. The levels nitric oxide...