Determination of the cause malignant pleural effusions is important for treatment and management, especially in cases unknown primaries. There are limited biomarkers available prediction effusion clinical practice. Hence, we evaluated levels five tumor (CEA, AFP, CA125, CA153 CA199) predicting a retrospective study. Kruskal-Wallis or Mann-Whitney U tests were carried out to compare markers among different forms neoplasia - lung squamous cell carcinoma, adenocarcinoma, small mesothelioma,...

It is unclear whether laparoscopic hepatectomy for hepatolithiasis patients with a history of biliary surgery achieves favorable clinical outcomes. This study aimed to evaluate the safety and feasibility reoperative (rLH). Patients who underwent anatomical liver resection between 2015 2022 were included in study. The outcomes rLH compared those open (rOH) initial (iLH). To ensure balanced baseline characteristics, propensity score matching was performed. A total 311 undergoing combined...

Currently, there is limited data on the risk factors associated with treatment delay in tuberculous meningitis (TBM). This study aimed to assess duration of TBM and investigate its determinants.During period from September 2009 February 2016, a retrospective cohort consecutive patients admitted our hospital was conducted determine TBM. Treatment defined as time interval onset symptoms (by patient recall) initiation stratified into two categories: ≤ 20 days, >20 days (median day days). Data...

Abstract Tuberculous empyema (TE) is associated with high mortality and morbidity. In the retrospective cohort study, we aimed to find risk factors for TE among pleural tuberculosis (TB) patients. Between July 2011 September 2015, all culture-confirmed TB patients (474 cases) were enrolled in our study. Empyema was defined as grossly purulent fluid. Demographic epidemiological data collected further analysis. Multivariate logistic regression analysis used evaluate of TB, age–adjusted odds...

The interferon-gamma release assay (IGRA) is more specific than the tuberculin skin test to discriminate between tuberculosis (TB) and nontuberculous mycobacterial (NTM) diseases. Here we performed a retrospective study evaluate performance of T-SPOT.TB in patients with NTM Between March, 2013 Nov, 2015, total 58 diseases had were enrolled, 30 definite diseases, 28 probable Their clinicopathological characteristics reviewed analyzed. Cultures for mycobacteria performed. indirect proportion...

In China, the prevalence of tuberculosis (TB) diseases and epidemiological trends in TB forms among children are still unclear; a retrospective study was conducted aiming to assess it.Between January 2007 September 2020, 1577 consecutive childhood patients (aged ≤ 15 years) were included study. Data, including demographic information underlying diseases, collected from medical records. Then, categorized reported according anatomical site disease. To analyze proportion each form disease,...

Abstract Tuberculous meningitis (TBM) remains a serious disease for children and its risk factors of poor outcome remain unclear. Therefore, retrospective study was conducted aiming to investigate the associated with childhood TBM. Between January 2006 December 2019, consecutive patients (≤ 15 years old) who had diagnosis TBM were included analysis. The demographic, clinical, laboratory, radiographic data collected from electronic medical records retrospectively. Poor defined as death or...

Abstract The prognostic factor for in-hospital mortality in tuberculosis (TB) patients requiring intensive care unit (ICU) remains unclear. Therefore, a retrospective study was conducted aiming to estimate the rate and risk factors high-burden setting. All with culture-confirmed TB that were admitted ICU of hospital between March 2012 April 2019 identified retrospectively. Data, such as demographic characteristics, comorbidities, laboratory measures mortality, obtained from medical records....

Current strategies for the prevention, diagnosis and treatment of pleural TB have been inadequate, several challenges issues related with reported.To summarize main features tuberculosis (TB) determine risk factors in delay.Retrospective analysis hospital records.Consecutive confirmed patients effusion were enrolled study. Demographic epidemiological data collected from electronic medical records. Treatment delay duration was stratified into two categories: <30 days ≥30 days. Multivariate...

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection is a serious threat to human health. γδT cells, which are characterized major histocompatibility complex (MHC) nonrestriction, rapidly activated and initiate anti-infectious immune responses in the early stages of Mtb infection. However, mechanism underlying recognition cells remains unclear. In this study, we pattern T-cell receptor (TCR) γδ complementary determinant region 3 (CDR3) repertoire TB patients using...

A negative interferon-γ release assay (IGRA) result might inappropriately lower the clinical suspicion for childhood tuberculosis (TB) and in delayed treatment initiation. However, risk factors associated with false-negative IGRA results children remain unclear. Between May 2012 January 2018, 156 culture-confirmed TB patients who had received T-SPOT.TB test were included. Data, including demographic information clinicopathological variables, collected via questionnaires. Univariate...

Background: Currently, the prevalence of nontuberculous mycobacteria (NTM) strains isolated from mycobacterial cultures has been well characterized. However, data on tuberculosis (TB) in patients with NTM disease remain unclear. Methods: Between January 2012 and August 2020, consecutive positive were included for analysis. The identification Mycobacteria spp. was performed using DNA array method or sequencing 16S rDNA. is diagnosed when same infectious agent identified at least two sputum...

OBJECTIVES: Our previous study demonstrated that superoxide dismutase levels were higher in tuberculous pleural effusions than malignant effusions, but this difference could not be used to discriminate between the two.The objective of present was investigate 2 and evaluate diagnostic significance effusion 2. METHODS: Superoxide concentrations determined from 54 patients with 33 using an enzyme-linked immunosorbent assay (ELISA) kit.Pleural interferon gamma tumor necrosis factor alpha also...

BACKGROUND:Interferon-gamma release assays have not been validated in active TB among pregnant women. Therefore, the objective of this retrospective study was to estimate diagnostic value T-SPOT.TB MATERIAL AND METHODS:Between May 2012 and 2015, 26 consecutive women with suspected were enrolled our study. The clinicopathological characteristics results reviewed analyzed. RESULTS:Pregnant patients divided into a group (n=21) Non-TB (n=5). In group, 5 had pulmonary TB, TB+ extrapulmonary 11...

The aim of this study was to investigate the diagnostic value superoxide dismutase (SOD) in tuberculous pleural effusions (TPEs) and malignant (MPEs). Pleural effusion (PE) samples from 100 patients were classified on basis diagnosis as TPE (n=57) MPE (n=43). activity SOD determined by pyrolgallol assay. A significant difference observed (P<0.01) between MPE, levels being significantly higher compared MPE. With a threshold 41 U/L, area under ROC curve 0.653, had sensitivity 61.4% specificity...

To describe the demographics, clinical characteristics and microbiologic findings of infant (≤2 years old) tuberculosis (TB) in a high TB burden country. Between Feb, 2007 Jun, 2015, 115 infants who admitted to our hospital were enrolled study. Their clinicopathological reviewed analyzed. The mean age was 10.1 ± 7.4 (SD) months, 84 (73.0 %) males. 23 patients (20.0 had isolated pulmonary TB, 18 (15.7 extrapulmonary (EPTB), remaining 74 (64.4 exclusively EPTB. most common site EPTB lymph node...

To establish the sensitivity of diagnostic criteria published by Marais and co-workers in 2010 for childhood tuberculous meningitis (TBM), a retrospective study on children with confirmed TBM was conducted.Between January 2006 December 2019, consecutively diagnosed were recruited retrospectively at our center. defined cases where any following met: presence acid-fast bacilli (AFB) cerebrospinal fluid (CSF) microscopy, CSF nucleic acid amplification test (NAAT, +), or M.tuberculosis cultured...

To date, the burden of childhood spinal TB in China has not been estimated, and current treatment is hindered by a lack evidence. This study aimed to review our experience TB.We reviewed medical records paediatric patients (≤15 years) admitted for (confirmed or possible) at Shandong Provincial Chest Hospital from January 2006 December 2019. Demographic, clinical, laboratory radiological data were collected analysed retrospectively.Seventy-two diagnosed with TB. 45 male (62.5%), 27 female...