A5100658571- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Enzyme Production and Characterization
- Orthodontics and Dentofacial Orthopedics
- Microbial Natural Products and Biosynthesis
- Tuberculosis Research and Epidemiology
- Salivary Gland Tumors Diagnosis and Treatment
- Atmospheric Ozone and Climate
- Neuroinflammation and Neurodegeneration Mechanisms
- Galectins and Cancer Biology
- interferon and immune responses
- HIV Research and Treatment
- Polysaccharides and Plant Cell Walls
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Oxidative Organic Chemistry Reactions
- Radiomics and Machine Learning in Medical Imaging
- Air Quality Monitoring and Forecasting
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Endodontics and Root Canal Treatments
- Alkaloids: synthesis and pharmacology
- Antibiotic Resistance in Bacteria
- Dental Radiography and Imaging
Qingdao University
2021-2025
Shandong University
2023
Affiliated Hospital of Qingdao University
2021
University of Colorado Boulder
2017-2019
Shandong Chest Hospital
2019
University of Colorado System
2018
Huaiyin Normal University
2018
Chinese Academy of Sciences
2010
Shanghai Institute of Organic Chemistry
2010
Preoperative differentiation between parotid Warthin's tumor (WT) and pleomorphic adenoma (PMA) is crucial for treatment decisions. The purpose of this study was to establish validate an MRI-based radiomics nomogram preoperative WT PMA.A total 127 patients with histological diagnosis or PMA from two clinical centres were enrolled in training set (n = 75; 34, 41) external test 52; 24, 28). Radiomics features extracted axial T1WI fs-T2WI images. A signature constructed, a score (Rad-score)...
Diabetes is a leading cause of death worldwide and results in over 3 million annual deaths. While insulin manages the disease well, many patients fail to comply with injection schedules, despite significant investment, more convenient oral formulation still unavailable. Studies suggest that glycosylation may stabilize peptides for delivery, but demanding production homogeneously glycosylated has hampered transition into clinic. We report here first total synthesis insulin. After...
Protein glycosylation has been shown to have a variety of site-specific and glycan-specific effects, but so far, the molecular logic that leads such observations elusive. Understanding structural changes occur being able correlate those with physical properties glycopeptide are valuable steps toward predict how specific patterns will affect stability glycoproteins. By systematically comparing features O-glycosylated carbohydrate-binding module Trichoderma reesei-derived Family 7...
The first asymmetric synthesis of indole alkaloid (+)-subincanadine F was successfully accomplished with the uncommon 7-endo-trig stereoselective radical cyclization as key step and its absolute configuration thus assigned.
Protein glycosylation is a diverse post-translational modification that serves myriad biological functions.
Protein O-glycosylation is a diverse, common, and important post-translational modification of both proteins inside the cell those that are secreted or membrane-bound. Much work has shown can alter structure, function, physical properties to which it attached. One gap remaining in our understanding O-glycoproteins how O-glycans might affect folding proteins. Here, we took advantage synthetic, homogeneous O-glycopeptides show certain glycosylation patterns have an intrinsic effect,...
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection is a serious threat to human health. γδT cells, which are characterized major histocompatibility complex (MHC) nonrestriction, rapidly activated and initiate anti-infectious immune responses in the early stages of Mtb infection. However, mechanism underlying recognition cells remains unclear. In this study, we pattern T-cell receptor (TCR) γδ complementary determinant region 3 (CDR3) repertoire TB patients using...
Many human proteins have the potential to be developed as therapeutic agents. However, side effects caused by direct administration of natural significantly slowed expansion protein therapeutics into clinic. Post-translational modifications (PTMs) can improve properties, but because significant knowledge gaps, we are considerably limited in our ability apply PTMs generate better therapeutics. Here, seek fill gaps studying a small representative chemotactic cytokine, RANTES. RANTES inhibit...