A5100444675- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Alzheimer's disease research and treatments
- Genomics and Chromatin Dynamics
- Molecular Biology Techniques and Applications
- Gut microbiota and health
- Parkinson's Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Fullerene Chemistry and Applications
- RNA modifications and cancer
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Carbon Nanotubes in Composites
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- Immune cells in cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Cell Technology (China)
2025
Sichuan University
2025
State Key Laboratory of Hydraulics and Mountain River Engineering
2025
State Key Laboratory of Medical Molecular Biology
2014-2024
Second Affiliated Hospital of Zhejiang University
2019-2024
Zhejiang University
2017-2024
Zhejiang Lab
2024
Affiliated Hospital of Hebei University
2024
South China Agricultural University
2017-2024
In a screen for gene copy-number changes in mouse mammary tumors, we identified tumor with small 350-kb amplicon from region that is syntenic to much larger locus amplified human cancers at chromosome 11q22. The contains only one known gene, Yap, encoding the mammalian ortholog of Drosophila Yorkie (Yki), downstream effector Hippo(Hpo)-Salvador(Sav)-Warts(Wts) signaling cascade, recently flies as critical regulator cellular proliferation and apoptosis. nontransformed epithelial cells,...
INTRODUCTION Parkinson’s disease (PD) is the second most common neurodegenerative disorder and leads to slowness of movement, tremor, rigidity, and, in later stages PD, cognitive impairment. Pathologically, PD characterized by accumulation α-synuclein Lewy bodies neurites. There degeneration neurons throughout nervous system, with dopamine substantia nigra pars compacta leading major symptoms PD. RATIONALE In brains patients, pathologic seems spread from cell via self-amplification,...
BackgroundThe effect of embolization the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.MethodsWe performed a multicenter, open-label, randomized trial China, involving symptomatic nonacute mass effect. Patients were assigned to undergo burr-hole drainage receive nonsurgical treatment at surgeon's discretion, and each group then randomly assigned, 1:1 ratio, liquid embolic material usual care. whose condition warranted craniotomy excluded. The...
Abstract T-cell receptor (TCR) γδ-expressing cells are conserved lymphocytes of innate immunity involved in first-line defense and immune surveillance. TCRγδ recognizes protein/nonprotein ligands without the help major histocompatibility complex (MHC), especially via direct binding to protein ligands, which is dependent primarily on δ chain complementary determining region 3 (CDR3δ). However, mechanism protein‒antigen recognition by human γδ TCRs remains poorly defined. We hypothesize that...
A large fraction of the animal genome is maintained in a transcriptionally repressed state throughout development. By generating viable Dnmt1(-)(/)(-) mouse cells we have been able to study effect DNA methylation on both gene expression and chromatin structure. Our results confirm that underlying pattern has profound histone acetylation major effector me-H3(K4) genome. We demonstrate many methylated genes are subject additional repression mechanisms also impact acetylation, data suggest late...
Abstract The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans eastern China since the spring of 2013. Fatal outcomes H7N9 infections are often attributed to pneumonia and acute respiratory distress syndrome (ARDS). There is urgent need discover biomarkers predicting progression disease fatal outcome potentially lethal flu infections, based on sound statistical analysis. We discovered that 34 48 cytokines chemokines examined this study were significantly...
Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder. Recent studies have implicated role for peroxisome proliferator-activated receptor γ coactivator protein-1α (PGC-1α) in PD and animal or cellular models of PD. The PGC-1α the function survival substantia nigra pars compacta (SNpc) dopamine neurons not clear. Here we find that there are four different isoforms expressed SH-SY5Y cells, these across subregions mouse brain. Adult conditional knock-out mice show...
Electroacupuncture (EA) and induced pluripotent stem cell (iPSC)-derived small extracellular vesicles (iPSC-EVs) have substantial beneficial effects on ischemic stroke. However, the detailed mechanisms remain unclear. Here, we explored underlying regulation of EA iPSC-EVs in microbiome-gut-brain axis (MGBA) after Ischemic stroke mice (C57BL/6) were subjected to middle cerebral artery occlusion (MCAO) or Sham surgery. treatments significantly improved neurological function neuronal intestinal...
Aneuploidy, frequently observed in premalignant lesions, disrupts gene dosage and contributes to neoplastic progression. Theodor Boveri hypothesized nearly 100 years ago that aneuploidy was due an increase centrosome number (multipolar mitoses) the resultant abnormal segregation of chromosomes. We performed immunocytochemistry, quantitative immunofluorescence, karyotypic analysis, time-lapse microscopy on primary human diploid epithelial cells fibroblasts better understand mechanism involved...
The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate tumorigenesis. We previously showed that the pivotal effector of this pathway, YAP, is amplified in tumors promotes epithelial-to-mesenchymal transition (EMT) malignant transformation. Here, we report overexpression TAZ, a paralog human mammary epithelial cells EMT and, particular, some invasive structures 3D cultures. TAZ also leads to migration anchorage-independent...
The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate tumorigenesis. Pivotal effectors of this are YAP/TAZ, transcriptional co-activators whose dysfunction contributes to epithelial-to-mesenchymal transition malignant transformation. Therefore, it is great importance decipher the mechanisms underlying regulations YAP/TAZ at various levels. Here we report that non-receptor tyrosine phosphatase 14 (PTPN14) interacts with...
Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP), one of the most prevalent chronic diseases, is characterized by persistent inflammation sinonasal mucosa. However, pathogenesis CRSwNP remains unclear. Here, we performed next-generation RNA sequencing and a comprehensive bioinformatics analyses to characterize transcriptome profiles, including mRNAs long noncoding RNAs (lncRNAs), in patients eosinophilic noneosinophilic CRSwNP. A total 1917 novel lncRNAs 280 known were identified....
Background and Purpose— The NLRP3 (nucleotide binding oligomerization domain-like receptor family pyrin domain-containing 3) inflammasome is a crucial component of the inflammatory response in early brain injury after subarachnoid hemorrhage (SAH). In this study, we investigated role dihydrolipoic acid (DHLA) lysosomal rupture, activation, determined underlying pathway. Methods— SAH was induced by endovascular perforation male Sprague–Dawley rats. DHLA administered intraperitoneally 1 hour...
The ligands of mitochondrial translocator protein (TSPO) have been widely used as diagnostic biomarkers for glioma. However, the true biological actions TSPO in vivo and its role glioma tumorigenesis remain elusive.