A5020800185- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Sulfur Compounds in Biology
- Immune cells in cancer
- Gut microbiota and health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Diet and metabolism studies
- Colorectal and Anal Carcinomas
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- Robotic Mechanisms and Dynamics
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Probiotics and Fermented Foods
- Photonic and Optical Devices
- Gallbladder and Bile Duct Disorders
- Asthma and respiratory diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Immune Cell Function and Interaction
Sun Yat-sen University
2023-2024
Second Affiliated Hospital of Nanchang University
2020-2024
Nanchang University
2020-2024
University of Hong Kong
2024
Weatherford College
2024
Analytical Biosciences (China)
2022-2023
Shanghai Maritime University
2023
BGI Group (China)
2022
Peking University
2019-2022
Guangzhou Medical University
2021-2022
Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC ecosystem five tumor-relevant sites, including omentum metastasis malignant Our data reveal potential roles ascites-enriched memory T cells as pool for tumor-infiltrating exhausted CD8+ helper 1-like cells. Moreover, tumor-enriched macrophages exhibited preference monocyte-derived ontogeny, whereas in ascites were more...
Colorectal cancer (CRC) is the third most common worldwide. The opening of TCGA and GEO databases has promoted progress CRC prognostic assessment, while aging-related risk signature never been mentioned.R software packages, GSEA software, Venn diagram, Metascape, STRING, Cytoscape, cBioPortal, TIMER GeneMANIA website were used in this study.Aging-related gene sets, GO_AGING, GO_CELL_AGING GO_CELLULAR_SENESCENCE, activated significantly tissues. We constructed an using LASSO COX regression...
Abstract R-loops play versatile roles in many physiological and pathological processes, are of great interest to scientists multiple fields. However, controversy about their genomic localization incomplete understanding regulatory network raise challenges for R-loop research. Here, we present R-loopBase (https://rloopbase.nju.edu.cn) tackle these pressing issues by systematic integration genomics literature data. First, based on 107 high-quality genome-wide mapping datasets generated 11...
Abstract Background The role of hydrogen sulfide (H 2 S) in cancer biology is controversial, including colorectal cancer. bell-shaped effect H S refers to pro-cancer action at lower doses and anti-cancer higher concentrations. We hypothesized that overexpression cystathionine-beta-synthase (CBS)/H exerts an inhibitory on colon cell proliferation metastasis. Methods Cell was assessed by Counting Kit-8 (CCK-8), clone-formation sphere formation assay. migration evaluated transwell Intracellular...
Abstract Carbon dots (CDs) have emerged as a promising category of nanomaterials for sensing applications, primarily due to their cost-effectiveness, thermal stability, low toxicity, and unique luminescence properties. CDs sensors been widely used in ion detection, but rarely ultraviolet (UV) light detection. In this paper, we synthesized via one one-step pyrolysis process. The exceptional stability is exhibited by ability maintain 100 % initial photoluminescence (PL) intensity over...
The incidence and mortality of pancreatic adenosquamous carcinoma (PASC) have received little attention. goal our study was to explore the overall epidemiological trend PASC at population level.The Surveillance, Epidemiology, End Results database used collect incidence, incidence-based (IB) mortality, patient details for from 2000 2017. Joinpoint regression tool examine trends in IB mortality. Kaplan-Meier approach survival analysis. Univariate multivariate Cox analyses were determine...
The rise in incidence and mortality of gastrointestinal mixed adenoneuroendocrine carcinoma (MANEC) has not been well focused. aim our study was to examine epidemiological trends incidence-based (IB) MANEC at a population level.The IB as data on affected patients from 2000 2016 were obtained the Surveillance, Epidemiology, End Results database. Trends assessed using Joinpoint regression. Kaplan-Meier method log-rank test used for survival analysis. Cox proportional hazards regression...
Abstract Background The application of molecular targeting therapy and immunotherapy has notably prolonged the survival patients with hepatocellular carcinoma (HCC). However, multidrug resistance high heterogeneity HCC still prevent further improvement clinical benefits. Dysfunction tumor-infiltrating natural killer (NK) cells was strongly related to progression benefits patients. Hence, an NK cell-related prognostic signature built up predict patients’ prognosis immunotherapeutic response....
BACKGROUND: The aim here was to elucidate the current survival condition of patients diagnosed with Ewing’s sarcoma bones and joints determine independent risk factors associated prognosis. DESIGN AND SETTING: Retrospective cohort study based on Surveillance, Epidemiology End Results (SEER) database in United States. METHODS: We identified 397 who were between January 2004 December 2013. multivariate Cox proportional hazards model used death by adjusting for various factors. RESULTS: one,...
Stomach adenocarcinoma (STAD) is one of the subtype gastric cancer with high invasiveness, extreme heterogeneity, morbidity, and mortality. The degradome most abundant class cellular enzymes that play an essential role in regulating activity carcinogenesis. An integrative machine learning procedure including 10 methods was performed to develop a prognostic degradome-based signature (DPS) TCGA, GSE15459, GSE26253, GSE62254 datasets. Investigations DPS concerning immune infiltration,...
Stomach adenocarcinoma (STAD) is one of the most prevalent malignances and ranks fifth in incidence third cancer-related death among all malignances. The prognosis STAD poor. circadian clock regulated by interlocked transcriptional-translational feedback loops that orchestrate rhythms some biological processes, including immune response metabolism. However, association between core genes patient unclear.In our study, bioinformatics methods were performed to explore expression prognostic...
Background. Liver hepatocellular carcinoma (LIHC) is a malignance with high incidence and recurrence. Pyroptosis programed cell death pattern which both activates the effective immune response causes damage. However, their potential applications of pyroptosis-related genes (PRGs) in prognostic evaluation immunotherapy LIHC are still rarely discussed. Methods. Comprehensive bioinformatics analyses based on TCGA-LIHC dataset were performed current study. Results. A total 33 PRGs selected to...
Abstract Background Primary hepatic mucoepidermoid carcinoma (HMEC) is extremely rare and the molecular etiology still unknown. The CRTC1-MAML2 fusion gene was previously detected in a primary HMEC, which often associated with MEC of salivary gland literature. Methods A 64-year-old male diagnosed HMEC based on malignant squamous cells mucus-secreting immunohistochemical examination. Fluorescence situ hybridization (FISH) used to detect HMEC. Whole-exome sequencing Sanger were reveal...
Several studies have demonstrated that the T-cell receptor (TCR) repertoire is associated with prognosis and immune therapy response in several types of cancer. However, comprehensive features TCR tumor-infiltrating circulating T cells, as well its clinical significance diagnosis hepatocellular carcinoma (HCC) patients, are still unknown. In this study, we perform paired tumor/peritumoral tissues peripheral blood samples from 58 patients HCC sequenced them high-throughput to comprehensively...
Background. Colon adenocarcinoma (COAD) is a malignancy with high incidence and associated poor quality of life. Dysfunction circadian clock genes disruption normal rhythms are the occurrence progression many cancer types. However, studies that systematically describe prognostic value immune-related functions in COAD lacking. Methods. Genomic data obtained from The Cancer Genome Atlas (TCGA) database was analyzed for expression level, mutation status, potential biological functions,...
Lipopolysaccharide (LPS) causes lesions of the epithelial barrier, which allows translocation pathogens from intestinal lumen to host's circulation. Hydrogen sulfide (H2S) regulates multiple physiological and pathological processes in colonic tissue, CBS-H2S axis involved gastrointestinal disorder. However, mechanism underlying effect on systemic inflammation colitis remains be illustrated.To investigate systematic related injuries LPS induced mechanisms.Wild type CBS-/+ mice were used...
A sensitivity-enhanced optical fiber sensor for the detection of dissolved ammonia in water based on Vernier effect is proposed and demonstrated. The comprises a sensing Fabry-Perot interferometer (S-FPI) reference (R-FPI) parallel. S-FPI an open cavity fabricated by dislocation welding single-mode fiber(SMF), which filled with mixture ultraviolet-curable resin NOA 170 Oxazine perchlorate (O17). R-FPI sealed cavity, constructed fusion splicing SMF hollow core (HCF). chemical reaction between...