A5086836616- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Heart Rate Variability and Autonomic Control
- CAR-T cell therapy research
- Pleural and Pulmonary Diseases
- Atomic and Subatomic Physics Research
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolomics and Mass Spectrometry Studies
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Multiple Myeloma Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Bacterial Identification and Susceptibility Testing
- Neuroblastoma Research and Treatments
- Sleep and related disorders
- Airway Management and Intubation Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Analytical Chemistry and Chromatography
- Clostridium difficile and Clostridium perfringens research
- Chromatography in Natural Products
Shandong Marine Resource and Environment Research Institute
2025
Jiangsu University
2025
Affiliated Hospital of Jiangsu University
2025
National Clinical Research
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Peking Union Medical College Hospital
2024
First Affiliated Hospital of Bengbu Medical College
2024
Northwest University
2024
Sichuan University
2023
Zhengzhou Central Hospital
2023
8005 Background: GC012F is a chimeric antigen receptor (CAR)-T cell therapy with B maturation (BCMA) and CD19 dual-target developed on the novel FasT CAR-T platform enabling 22-36 h manufacturing. Our previous results were presented at ASCO EHA 2022 for 29 pts (NCT04236011; NCT04182581), which demonstrated treatment led to deep durable response in RRMM pts. Furthermore, initial showed that considerable efficacy safety high-risk transplant-eligible newly diagnosed MM (Blood 2022; 140...
Stroke is a leading cause of mortality and disability globally. Among ischemic stroke patients, those with moderate to severe consciousness disorders constitute particularly high-risk subgroup. Accurate predictive models are essential for guiding clinical decisions in this population. This study aimed develop validate an automated scoring system using machine learning algorithms predicting short-term (3- 7-day) relatively long-term (30- 90-day) retrospective observational utilized data from...
Previous studies indicate that decreased heart-rate variability (HRV) is related to the risk of death in patients after acute myocardial infarction (AMI). However, conventional indices HRV have poor predictive value for mortality. Our aim was develop novel models based on support vector machine (SVM) study integrated features improving stratification AMI. A series dynamic parameters from 208 were analyzed a mean follow-up time 28 months. Patient electrocardiographic data classified as either...
The goal of this study is to determine the feasibility, diagnostic accuracy, and risk factor complications computed tomography (CT)-guided percutaneous cutting needle biopsy (PCNB) for small lung nodules.From January 2014 May 2015, 141 patients with nodule were performed CT-guided PCNB procedure. Data on technical success, complication collected analyzed.Technical success nodules was 100%. A total punctured. mean time procedure 15.7 ± 4.3 minutes. results included malignancy (n = 79),...
Background: Talaromyces marneffei is prevalent in South Asia.Latent infection of travellers make the diagnosis difficult.There are similarities clinical manifestations between and lymphoma.Brain abscess a rare form infection.Case Presentation: We reported very case 19-year-old man with HIV who suffered from brain mass lymphadenopathy.His blood culture, bone marrow culture sputum all grew marneffei.One month after treatment voriconazole, symptoms improved except mass.Surgical incision showed...
Fu tea is receiving increasing attention for its specific aroma, flavor, and dramatic functional benefits. Herein, we explored the effects underlying mechanisms of loose (FLT), brick (FBT), diet pills (orlistat) on a high-fat (HFD)-induced obesity. The results indicated that FLT FBT administration effectively inhibited weight gain, glucose metabolic dysregulation, fat accumulation in organs, hepatic kidney injury, oxidative stress induced by HFD. Additionally, treatments improved lipid...
Abstract Background Primary hepatic mucoepidermoid carcinoma (HMEC) is extremely rare and the molecular etiology still unknown. The CRTC1-MAML2 fusion gene was previously detected in a primary HMEC, which often associated with MEC of salivary gland literature. Methods A 64-year-old male diagnosed HMEC based on malignant squamous cells mucus-secreting immunohistochemical examination. Fluorescence situ hybridization (FISH) used to detect HMEC. Whole-exome sequencing Sanger were reveal...
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: GC012F is a B cell maturation antigen (BCMA) CD19 dual-targeting chimeric receptor (CAR)-T developed on the novel FasTCAR-T platform enabling 22-36 h manufacturing. Our previous results presented at ASCO EHA 2022 for 29 pts (NCT04236011; NCT04182581), demonstrated that treatment led to deep durable response in RRMM pts. Furthermore, initial showed considerable efficacy safety of newly diagnosed high-risk...
Sleep disorders (SDs) are usually associated with an increase in frequency of ventricular tachycardia (VT). However, the relationship between SDs and prevalence VT within first week acute myocardial infarction (AMI) remains unclear. This study aimed to evaluate their associations potential mechanisms.This structured questionnaire-based cross-sectional enrolled 303 patients AMI from a hospital northern China. Pittsburgh Quality Index (PSQI) was used determine sleep quality subjects. Heart...
Recently, a new type of pulmonary nodule positioning needle has been adopted clinically. We aimed to evaluate the efficacy and safety localization needles compared with coils for simultaneous multiple nodules guided by computed tomography (CT) prior video-assisted thoracoscopic surgery (VATS).From January 2021 March 2022, 87 from 40 patients were localized using needle. From 2020 December 2020, 68 in 31 coils. The relative outcomes compared.The success rate group was 97.7% while that coil...
Background In patients with invasive fungal infection (IFI), the steady-state serum trough concentration ( C min ) of voriconazole (VCZ) is highly variable and can lead to treatment failure < 0.5 mg/L) toxicity ≥ 5.0 mg/L). However, It remains challenging determine ideal maintenance dose achieve desired level quickly. Aims This randomized, prospective observational single-center study aimed identify factors affecting VCZ- create an algorithmic model predict necessary dose. MeThe...
The aim of this study is to develop a predictive model for identifying true negatives among nonspecific benign results on computed tomography-guided lung biopsy.This was single-center retrospective study. Between December 2013 and May 2016, total 126 patients with biopsy were used as the training group create true-negative findings. June 2016 2017, additional 56 validation test constructed model.In group, lesions from biopsied. Biopsies 106 20 false-negatives. Univariate multivariate...
Patients with advanced biliary tract cancer (BTC) have a poor survival. We aim to evaluate the efficacy and safety of nab-paclitaxel plus gemcitabine cisplatin regimen in Chinese BTC patients.
Background: This study aims to investigate the effect of miR-212-5p overexpression targeting suppressor cytokine signaling 5 (SOCS5) on malignant proliferation liver cancer cells HepG2 and tumor formation in nude mice with transplanted tumors. Methods: Luciferase reporter assay was used detect targeted relationship between SOCS5, SOCS5 overexpressed by pcDNA vector. MiR-212-5p mimic pc DNA-SOCS5 were transfected into alone or combination, randomly divided four groups, control group, group +...
CT scans combined with Mimics software were used to measure femoral offset (FO), rotation center height (RCH) and lower leg length discrepancy (LLD) following total hip arthroplasty (THA), the relationship between FO, RCH LLD after THA is discussed.
<title>Abstract</title> <bold>Background: </bold>Cancer screening strategies play a crucial role in early detection and subsequent management of lung cancer colorectal cancer. However, there remains paucity high-quality evidence from developing regions. The CHinA National CancEr Screening (CHANCES) Trial aims to comprehensively evaluate compare different for (CRC) the Chinese population. <bold>Methods: </bold>The CHANCES trial is randomized controlled aimed at assessing effectiveness using...
Various factors leading to unexpected false-positive 131 I uptake have been extensively studied in patients with differentiated thyroid carcinoma. In this case, we present a patient who underwent achalasia surgery and subsequently exhibited abnormal on SPECT/CT imaging. The was known case of papillary carcinoma that suggested therapy. showed linear increased activity the distended esophagus.
Abstract To evaluate the clinical efficiency, feasibility, and safety of computed tomography (CT)-guided trans-scapular coil localization (TSCL) approach to treating scapula-blocked pulmonary nodules (SBPNs). In total, 105 patients with underwent CT-guided CL subsequent video-assisted thoracoscopic surgery (VATS)-guided wedge resection (WR) between January 2016 July 2020. Six these (5.7%) had SBPNs that led them undergo TSCL. Rates technical success localization-related complications were...