Coronary artery disease (CAD) is a complex, multifactorial and leading cause of mortality world wide. Over the past decades, great efforts have been made to elucidate underlying genetic basis CAD massive data accumulated. To integrate these together provide useful resource for researchers, we developed CADgene, comprehensive database genes. We manually extracted CAD-related evidence more than 300 candidate genes from over 1300 publications studies. classified into 12 functional categories...

The effects of hydrogen sulfide (H 2 S) on blood—brain barrier (BBB) and brain edema after cardiac arrest (CA) cardiopulmonary resuscitation (CPR) remain poorly understood. We investigated the exogenous 80-p.p.m. H S gas BBB, water content, neurologic outcome, survival rate CA CPR. Cardiopulmonary followed induced in rats by ventricular fibrillation for 6 minutes. Results show that inhalation significantly reduced permeability BBB both cortex hippocampus at 24 hours resuscitation. Hydrogen...

Platelet-activating factor (PAF) and lysophosphatidylcholine (LPC) are potent inflammatory lipids. Elevated levels of PAF LPC associated with the onset diabetic retinopathy neurodegeneration. However, molecular mechanisms underlying such defects remain elusive. LPCAT1 is a newly reported lysophospholipid acyltransferase implicated in anti-inflammatory response by its role conversion to PC. Intriguingly, enzyme also catalyzes synthesis from lyso-PAF use acetyl-CoA as substrate. The present...

Embryos propagated from vegetative organs can maintain the excellent characteristics of ortet tree and make full use advantages somatic embryogenesis technology in large-scale clonal propagation forest trees. However, trees, a major obstacle to reproducing seedlings through is challenge inducing embryos using as explants. In this study, we have successfully developed procedure induce (SE) adult hybrid sweetgum trees for first time. Leaves, petioles, stem segments isolated test-tube three...

Dihydromyricetin (DHM), the main bioactive flavonoid in vine tea, exerts multiple health beneficial effects. This work aimed to identify whether a naturally derived flavonoid product, DHM, can significantly attenuate metabolic syndrome and improve insulin sensitivity.10-week-old db/db mice were randomly assigned receive antidiabetic agent metformin (Met, 50 mg/kg BW), DHM (1.0 g 0.5 g/kg BW) or placebo simultaneously fed high-fat diet for 8 weeks. The general status of animals was observed...

Background/Aims: The effects of H2S on cerebral inflammatory reaction after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) remain poorly understood. In this study, we investigated the exogenous 40 ppm 80 gas neurological outcome CA/CPR. Methods: CA was induced by ventricular fibrillation followed CPR. Forty or inhaled for 1 h immediately following levels IL-1ß, IL-6 TNF-a, myeloperoxidase (MPO) activity, expression iNOS ICAM-1, phosphorylation translocation NF-κB were evaluated...

Yindan xinnaotong, a compound preparation used in traditional Chinese medicine, is composed of eight herbs: Ginkgo biloba leaf (yinxingye), Salvia miltiorrhizae (danshen), Herba gynostemmatis (jiaogulan), Erigerontis herba (dengzhanxixin), Allii sativi bulbus (dasuan), Notoginseng radixe rhizoma (sanqi), Crataegi fructus (shanzha), and Borneolum (tianranbingpian). xinnaotong primarily to treat cardiovascular cerebrovascular diseases. However, date, no scientific methods have been established...

Abstract Transcription factor Wilms' tumor 1 (WT1) was originally identified as a suppressor for tumor, but it is also overexpressed in variety of cancer cells, suggesting potential oncogenic function WT1. It important to understand molecular mechanisms underlying these dual functions WT1 tumorigenesis. In the current study, we report synergistic role signal transducers and activators transcription 3 (STAT3) development, including tumor. STAT3 interacts with through its conserved domains...

Teicoplanin, an antibiotic, has poor clinical efficacy when using the current drug label's recommended regimen, which is approved by China Food and Drug Administration. This study explores appropriate loading maintenance doses of teicoplanin evaluates therapeutic target trough concentration (minimum [Cmin]).All patients treated with from February 2015 to August 2016 at Zhengzhou Central Hospital were screened for enrollment. A total 113 subjects included then divided into four groups:...

Myocardial infarction is a common cardiovascular disease. MicroRNA-16-5p (miR-16-5p) was upregulated in heart and kidney hypoxia/reoxygenation (H/R) injury. However, the role of miR-16-5p myocardial injury still unclear.Human adult ventricular cardiomyocytes (AC16) were treated with ischemia/reperfusion (H/R). The level evaluated through real-time PCR. activity lactate dehydrogenase (LDH) creatine kinase-MB (CK-MB) detected via LDH CK-MB monitoring kits. Cell viability examined...

Abstract Yindanxinnaotong (YD), a traditional Chinese medicine, has been introduced toclinical medicine for more than decade, while its pharmacological properties arestill not to be well addressed. This report aimed explore theanti-atherosclerosis and underlying mechanisms of YD. We initiallyperformed computational prediction based on network pharmacology simulation,which clued YD exerted synergistically anti-atherosclerosis by vascularendothelium protection, lipid-lowering,...

Traditional Chinese medicines largely lack adequate and scientifically rigorous evidence regarding efficacy functional mechanisms. The present study was aimed to confirm the hypoglycemic effect of Tangningtongluo (TNTL) formula, a traditional Miao medicine, in two animal models: high-fat diet streptozotocin- (STZ-) induced diabetic rats C57BL/KsJ-db/db mice. After 4 weeks, TNTL intervention STZ-induced yielded significant improvement on glucose tolerance test. Moreover, islet histopathology...

Atherosclerosis is a kind of chronic inflammatory disease. A crucial pathology change atherosclerosis the migration activated VSMCs to intima where they interact with leukocytes by expressing adhesion molecules, including intercellular cell molecule-1 (ICAM-1) and vascular (VCAM-1). Moreover, monocyte chemoattractant protein-1 (MCP-1) expressed plays an important role in recruiting monocytes macrophages. Leech (Whitmania pigra Whitman) traditional Chinese medicine treat cardiovascular...

Yindan Xinnaotong capsule has been used for treating cardio-cerebrovascular diseases several decades in China. Exercise training can protect against the development of atherosclerosis. The aim present study is to evaluate joint effect YXC and exercise on atherosclerosis rats.A combined method involving low shear stress a high-fat diet was establish model rats. Partial ligation left common carotid artery performed, then rats were divided into 9 treatment groups according 3 × factorial design...

Aim To compare ‘progression to insulin’ for three cohorts on oral antidiabetic medication combinations: metformin/sulphonylurea (Met/ SU ), metformin/thiazolidinedione TZD ) and sulphonylurea/thiazolidinedione ( / ). Methods Retrospective cohort analysis design was used. The subjects were US nationwide members of military their families. A total 5608 patients who monotherapy at least 1 year before adding a second agent regimen between October 2001 September 2008 participated in this study....

There are few studies on the neuropharmacological properties of asparagus, which was applied in Chinese traditional medicine as a tonic and heat-clearing agent. The present study designed to investigate anxiolytic-like activity aqueous extract asparagus stem (AEAS) using elevated plus maze (EPM) Vogel conflict tests (VCT) mice. AEAS significantly increased percentage time spent open arms EPM, when compared with control group. In drinking test, numbers punished licks 177% 174% by treatment at...