A5100733620- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- Aquaculture disease management and microbiota
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Viral Infections and Outbreaks Research
- Sirtuins and Resveratrol in Medicine
- interferon and immune responses
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Biochemical and Molecular Research
- Natural product bioactivities and synthesis
- Drug Transport and Resistance Mechanisms
- Autophagy in Disease and Therapy
Aerospace Center Hospital
2019-2025
Peking University
2019-2025
Tianjin Medical University Cancer Institute and Hospital
2021-2024
Hubei University of Medicine
2017-2024
Hunan Agricultural University
2023-2024
Guangxi Medical University
2024
Institute of Microbiology
2016-2023
Beijing Anzhen Hospital
2023
Capital Medical University
2023
First Affiliated Hospital of Henan University
2023
Reactive oxygen species are of interest in biology and medicine because evidence relating them to aging disease processes. A relatively simple but sensitive reliable method for quantifying the radical absorbance capacity (ORAC) antioxidants biological tissues has been automated use with COBAS FARA II centrifugal analyzer a fluorescence-measuring attachment. In this assay, beta-phycoerythrin (beta-PE) is used as an indicator protein, 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)...
During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts West Africa. No approved antiviral drugs are available for treatment currently. A retrospective clinical case series was performed EVD patients in Sierra Leone-China Friendship Hospital. Patients with confirmed were sequentially enrolled and treated either World Health Organization (WHO)-recommended supportive therapy (control group) from 10 to 30 October, or WHO-recommended plus favipiravir (T-705) 1 November...
Chemoresistance is a major factor contributing to the poor prognosis of patients with pancreatic cancer, and cancer stemness one most crucial factors associated chemoresistance very promising direction for treatment. However, exact molecular mechanisms have not been completely elucidated.m6A-RNA immunoprecipitation sequencing were used screen m6A-related mRNAs lncRNAs. qRT-PCR FISH utilized analyse DDIT4-AS1 expression. Spheroid formation, colony Western blot flow cytometry assays performed...
Sepsis-associated encephalopathy (SAE), a common neurological complication of sepsis, is heterogenous complex clinical syndrome caused by the dysfunctional response host to infection. This leads excess mortality and morbidity worldwide. Despite relevance with high incidence, there lack understanding for its both acute/chronic pathogenesis therapeutic management. A better molecular mechanisms behind SAE may provide tools enhance efficacy. Mounting evidence indicates that some types...
Melanoma, the most aggressive skin cancer, is mainly treated with BRAF inhibitors or immunotheareapy. However, patients who initially responded to immunotheareapy become resistant following relapse. Ferroptosis a form of regulated cell death characterized by its dependence on iron ions and accumulation lipid reactive oxygen species (ROS). Recent studies have demonstrated that ferroptosis good method for tumor treatment, homeostasis closely associated ferroptosis. Iron regulatory protein...
Abstract Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne high fatality and expanding endemic. Currently, effective anti-SFTSV intervention remains unavailable. Favipiravir (T-705) was recently reported to show in vitro animal model antiviral efficacy against SFTSV. Here, we conducted a single-blind, randomized controlled trial assess the safety of T-705 treating SFTS (Chinese Clinical Trial Registry website, number ChiCTR1900023350). From May August...
beta-Amyloid protein (Abeta), a major component of brain senile plaques in Alzheimer's disease, is known to be directly responsible for the production reactive oxygen species (ROS) and induction apoptosis. In this study, protective effect puerarin, an isoflavone purified from radix Chinese herb Pueraria lobata, on Abeta-induced rat pheochromocytoma (PC12) cultures was investigated. Although exposure PC12 cells 50 microM Abeta25-35 caused significant viability loss apoptotic rate increase,...