A5081728299- Viral Infections and Vectors
- Advancements in Transdermal Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Advanced Drug Delivery Systems
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- interferon and immune responses
- Dermatology and Skin Diseases
- Viral Infections and Outbreaks Research
- Viral Infectious Diseases and Gene Expression in Insects
- Insect Resistance and Genetics
- Supramolecular Self-Assembly in Materials
- Inflammasome and immune disorders
- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Long-Term Effects of COVID-19
- RNA Interference and Gene Delivery
- Advanced ceramic materials synthesis
- Hydrogels: synthesis, properties, applications
- Smart Grid Energy Management
- Microgrid Control and Optimization
- Cell death mechanisms and regulation
- Photoreceptor and optogenetics research
Guangxi University
2022-2025
Wuhan Institute of Virology
2009-2024
Chinese Academy of Sciences
2009-2024
Queen's University Belfast
2020-2024
University of Chinese Academy of Sciences
2019-2024
Fujian Medical University
2024
Nanchang Hangkong University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Shanghai Medical College of Fudan University
2024
Guangdong Ocean University
2023-2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to illness and multi-organ failure in critically ill patients. Although the virus-induced lung damage inflammatory cytokine storm are believed be directly associated with disease 2019 (COVID-19) clinical manifestations, underlying mechanisms of virus-triggered responses currently unknown. Here we report that SARS-CoV-2 activates caspase-8 trigger cell apoptosis processing epithelial cells. The processed cytokines...
High mechanical performances of macroscopic graphene oxide (GO) papers are attracting great interest owing to their merits lightweight and multiple functionalities. However, the loading role individual nanosheets its effect on properties GO not yet well understood. Herein, we effectively tailored interlayer adhesions by introducing small molecules, that is, glutaraldehyde (GA) water into gallery regions. With help in situ Raman spectroscopy, compared varied load-reinforcing roles nanosheets,...
The coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome 2 (SARS-CoV-2) has now spread to >200 countries posing a global public health concern. Patients with comorbidity, such as hypertension suffer more infection elevated mortality. development of effective antiviral drugs is in urgent need treat COVID-19 patients. Here, we report that calcium channel blockers (CCBs), type antihypertensive drug widely used clinics, inhibited post-entry replication events...
Nuclear entry of HIV-1 replication complexes through intact nuclear pore is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages early replication. Applying quantitative microscopy reverse-transcription and pre-integration-complexes (RTC/PIC), we show that CPSF6 strongly recruited to but absent from cytoplasmic RTC/PIC primary human macrophages. Depletion or lack binding led accumulation subviral...
Abstract SARS-CoV-2 induced marked lymphopenia in severe patients with COVID-19. However, whether lymphocytes are targets of viral infection is yet to be determined, although RNA or antigen has been identified T cells from patients. Here, we confirmed that could detected patient peripheral blood (PBCs) postmortem lung cells, and the infectious virus also antigen-positive PBCs. We next prove infects lymphocytes, preferably activated CD4 + vitro. Upon infection, RNA, subgenomic protein...
The coronavirus disease 2019 (COVID-19) pandemic is an ongoing global health concern, and effective antiviral reagents are urgently needed. Traditional Chinese medicine theory-driven natural drug research development (TCMT-NDRD) a feasible method to address this issue as the traditional formulae have been shown in treatment of COVID-19. Huashi Baidu decoction (Q-14) clinically approved formula for COVID-19 therapy with anti-inflammatory effects. Here, integrative pharmacological strategy was...
Oral administration and intramuscular (IM) injection are commonly recommended options for human immunodeficiency virus (HIV) treatment. However, poor patient compliance due to daily oral dosing, pain at sites the demand trained healthcare staff injections limit success of these routes, especially in low-resource settings. To overcome limitations, first time, we propose novel bilayer dissolving microneedles (MNs) intradermal delivery long-acting nanosuspensions antiretroviral (ARV) drug...
Using the inclusion complex of trans azobenzene and cyclodextrin as a photo-switchable crosslinker, dextran based photo-responsive hydrogel system has been constructed employed for light controlled protein release system.
The steps from HIV-1 cytoplasmic entry until integration of the reverse transcribed genome are currently enigmatic. They occur in ill-defined reverse-transcription- and pre-integration-complexes (RTC, PIC) with various host viral proteins implicated. In this study, we report quantitative detection functional RTC/PIC by labeling nascent DNA combined integrase. We show that CA (capsid) protein remains associated but is lost on nuclear PIC a HeLa-derived cell line. contrast, were almost always...
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne that carries a high fatality rate of 12%-50%. In-depth understanding the SFTSV-induced pathogenesis mechanism critical for developing effective anti-SFTS therapeutics. Here, we report transcriptomic analysis blood samples from SFTS patients. We observe strong correlation between inflammatory responses and disease progression fatal outcome. Quantitative proteomic SFTSV infection confirms induction...
Abstract Antibody-dependent cellular cytotoxicity (ADCC) responses to viral infection are a form of antibody regulated immune mediated through the Fc fragment. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered ADCC contributes COVID-19 disease development is currently not well understood. To understand potential correlation between and development, we analyzed activity neutralizing response in 255 individuals ranging from asymptomatic fatal infections over 1 year...
Rationale: Many viral infections are known to activate the p38 mitogen-activated protein kinase (MAPK) signaling pathway. However, role of activation in infection and underlying mechanism remain unclear. The virus-hijacked MAPK was investigated this study. Methods: correlation hepatitis C virus (HCV) studied patient tissues primary human hepatocytes (PHHs) by immunohistochemistry western blotting. Coimmunoprecipitation, GST pulldown confocal microscopy were used investigate interaction p38α...
Abstract The development of dissolving microneedles (DMN) is one the advanced technologies in transdermal drug delivery systems, which precisely deliver drugs through a rapid dissolution polymers after insertion into skin. In this study, we fabricated nanoemulsion-loaded microneedle arrays for intradermal and delivery. For task, model (amphotericin B, AmB)-loaded nanoemulsion (NE) were prepared by probe-sonication method. AmB-loaded-NE was using Capmul MCM C-8 EP/NF, Tween ® 80, poly(vinyl...