A5053533247- Bacterial biofilms and quorum sensing
- Plasma Applications and Diagnostics
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Peptidase Inhibition and Analysis
- Inhalation and Respiratory Drug Delivery
- Biochemical and Structural Characterization
- Enzyme Production and Characterization
- Microbial Community Ecology and Physiology
- Antimicrobial agents and applications
- Supramolecular Self-Assembly in Materials
- Protease and Inhibitor Mechanisms
- Oral microbiology and periodontitis research
- Enzyme Catalysis and Immobilization
- Genomics and Phylogenetic Studies
- Ionic liquids properties and applications
- Chemical Synthesis and Analysis
- Legionella and Acanthamoeba research
- Seaweed-derived Bioactive Compounds
- Antimicrobial Resistance in Staphylococcus
- Advanced biosensing and bioanalysis techniques
- Urinary Tract Infections Management
- Chemistry and Chemical Engineering
- Click Chemistry and Applications
Queen's University Belfast
2016-2025
Queens University
2015-2024
University of Limerick
2024
University of Oxford
2024
University of Cambridge
2023-2024
Shiraz University
2022
Marine Institute
2019
National University of Ireland
2017-2018
University of Ulster
2016-2017
Belfast City Hospital
2016-2017
Microbial biofilms are ubiquitous in nature and represent the predominant mode of growth microorganisms. A general characteristic biofilm communities is that they tend to exhibit significant tolerance antimicrobial challenge compared with planktonic bacteria same species The antibiofilm activity a series 1-alkyl-3-methylimidazolium chloride ionic liquids has been evaluated against panel clinically microbial pathogens, including MRSA. comparison established presented. In general, these...
The potential application of phage therapy for the control bacterial biofilms has received increasing attention as resistance to conventional antibiotic agents continues increase. present study identifies antimicrobial synergy between bacteriophage T4 and a antibiotic, cefotaxime, via standard plaque assay and, importantly, in vitro eradication host strain Escherichia coli 11303. Phage-antibiotic (PAS) is defined phenomenon whereby sub-lethal concentrations certain antibiotics can...
Bacteria exist, in most environments, as complex, organised communities of sessile cells embedded within a matrix self-produced, hydrated extracellular polymeric substances known biofilms. Bacterial biofilms represent ubiquitous and predominant cause both chronic infections associated with the use indwelling medical devices such catheters prostheses. Such typically exhibit significantly enhanced tolerance to antimicrobial, biocidal immunological challenge. This renders them difficult,...
Quinoline derivatives are known to possess a range of bioactive and medicinal activities, which have been exploited in the design antibacterial, antifungal antimalarial compounds. In this study, we report on microbiological toxicity series 1-alkylquinolinium bromides against clinically relevant microorganisms, both planktonic sessile (biofilm) cultures. A comparison antimicrobial activity bacteria established biofilms is presented. general, ionic liquids excellent, broad spectrum...
Antibiotics have been the cornerstone of clinical management bacterial infections since their discovery in early part last century. Eight decades later, widespread, often indiscriminate use, has resulted an overall reduction effectiveness, with reports multidrug-resistant bacteria now commonplace. Increasing reliance on indwelling medical devices, which are inherently susceptible to biofilm-mediated infections, contributed unacceptably high rates nosocomial placing a strain healthcare...
Abstract: Gentamicin is an aminoglycoside antibiotic commonly used for treating Pseudomonas infections, but its use limited by a relatively short half-life. In this investigation, developed controlled-release gentamicin formulation using poly(lactide-co-glycolide) (PLGA) nanoparticles. We demonstrate that entrapment of the hydrophilic drug into hydrophobic PLGA polymer can be improved increasing pH formulation, reducing hydrophilicity and thus enhancing entrapment, achieving levels up to...
Staphylococcus epidermidis biofilm formation is responsible for the persistence of orthopedic implant infections. Previous studies have shown that exposure S. biofilms to sub-MICs antibiotics induced an increased level persistence. BODIPY FL-vancomycin (a fluorescent vancomycin conjugate) and confocal microscopy were used show penetration through sub-MIC-vancomycin-treated was impeded compared control, untreated biofilms. Further experiments showed increase in extracellular DNA (eDNA)...
Current strategies to treat pelvic organ prolapse (POP) or stress urinary incontinence (SUI), include the surgical implantation of vaginal meshes. Recently, there have been multiple reports issues generated by these meshes conventionally made poly(propylene). This material is not ideal candidate, due its mechanical properties leading complications such as chronic pain and infection. In present manuscript, we propose use an alternative material, thermoplastic polyurethane (TPU), loaded with...
Self-assembling dipeptides conjugated to naphthalene show considerable promise as nanomaterial structures, biomaterials, and drug delivery devices. Biomaterial infections are responsible for high rates of patient mortality morbidity. The presence biofilm bacteria, which thrive on implant surfaces, a huge burden healthcare budgets, they highly resistant current therapeutic strategies. Ultrashort cationic self-assembled peptides represent innovative cost-effective strategy form antibacterial...
Antibiotics, such as ofloxacin (OFX) and ciprofloxacin (CFX), are often detected in considerable concentrations both wastewater effluents surface water. This poses a risk to non-target organisms human health. The aim of this work was study atmospheric cold plasma (ACP) degradation antibiotics water meat effluent explore any residual antimicrobial activity samples submitted the process. results revealed that ACP successfully degraded studied reaction mechanism is principally related attack by...