A5040947495- Crystallography and molecular interactions
- Crystallization and Solubility Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Metal-Organic Frameworks: Synthesis and Applications
- X-ray Diffraction in Crystallography
- Ionic liquids properties and applications
- Supramolecular Chemistry and Complexes
- Covalent Organic Framework Applications
- Force Microscopy Techniques and Applications
- Chemical Synthesis and Analysis
- Radical Photochemical Reactions
- Mechanical and Optical Resonators
- Machine Learning in Materials Science
- Advanced materials and composites
- Pickering emulsions and particle stabilization
- Organoboron and organosilicon chemistry
- Membrane Separation and Gas Transport
- Advanced ceramic materials synthesis
- Nanomaterials for catalytic reactions
- Ultrasound and Cavitation Phenomena
- Nanofabrication and Lithography Techniques
- Synthesis and Reactivity of Heterocycles
- Carbon Nanotubes in Composites
- Photochromic and Fluorescence Chemistry
- Graphene and Nanomaterials Applications
Queen's University Belfast
2010-2024
University of Birmingham
2024
University of Bradford
2020-2022
University of Pittsburgh at Bradford
2020
University of Ulster
2015-2019
Belfast City Hospital
2015-2019
BTG International (United Kingdom)
2018
Continuous flow mechanochemical and melt-phase synthesis at kg h<sup>−1</sup> rates from solid reagents either no solvent, or only minimal is reported.
Several organic reactions have been achieved quantitatively without any added solvent, using solid or liquid reagents, on a continuous basis; products are typically obtained directly in analytically pure form, requiring no work-up.
The scale-up of mechanochemical methods could play a transformative role in making manufacturing processes the pharmaceutical industry greener by eliminating solvent use and recovery. Combined with energy-efficient continuous processing that consolidates reaction steps, mechanochemistry's environmental economic benefits may translate across product supply chains. Here, we evaluate numerous sustainability green chemistry metrics for producing nitrofurantoin, an active ingredient (API), via...
Quinoline derivatives are known to possess a range of bioactive and medicinal activities, which have been exploited in the design antibacterial, antifungal antimalarial compounds. In this study, we report on microbiological toxicity series 1-alkylquinolinium bromides against clinically relevant microorganisms, both planktonic sessile (biofilm) cultures. A comparison antimicrobial activity bacteria established biofilms is presented. general, ionic liquids excellent, broad spectrum...
Mechanochemical synthesis has been applied to the rapid of Deep Eutectic Solvents (DESs), including Reline 200 (choline chloride : urea, 1 2), in a continuous flow methodology by Twin Screw Extrusion (TSE).
Mechanochemical synthesis, i.e., reactions conducted by grinding solid reactants together with no or minimal solvent, has been demonstrated as an excellent technique for the formation of both organic and inorganic compounds. Mechanochemistry is viewed alternative approach to chemical synthesis not always considered when developing manufacturing processes fine chemicals. Here, recent advances are highlighted regarding mechanochemical utilizing a well‐developed continuous – extrusion,...
Although mechanochemical synthesis is becoming more widely applied and even commercialised, greater basic understanding needed if the field to progress on less of a trial-and-error basis. We report that reaction in ball mill exhibits unusual sigmoidal feedback kinetics differ dramatically from simple first-order for same solution. An induction period followed by rapid increase rate before decreases again as goes completion. The origin these found be cycle involving both chemical mechanical...
Chemoenzymatic oligomerisation of <sc>l</sc>-amino acids was successfully developed using mechanochemical techniques.
Mechanochemical chemoenzymatic peptide and amide bond formation catalysed by papain was studied ball milling.
Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for products.
A study on the translation of a solid-state fluorination reaction from mechanochemical mixer-mill to continuous twin-screw extruder is discussed herein.
Chemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or carried out as multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.
A continuous, scalable, and solvent-free method for the synthesis of various naphthalic imides perylene diimides (PDIs) using twin-screw extrusion (TSE) is reported. Using TSE, were obtained quantitatively without need excess amine reactant or product purification. With good functional-group tolerance, alkyl benzyl derived PDIs (incl. commercial dyes) in 50-99 % yield. Use K2 CO3 , enabled more difficult aniline-derived PDIs. Furthermore, an automated continuous TSE process Pigments Black 31...
In this Guest Editorial the recently funded COST Action: CA18112 – Mechanochemistry for Sustainable Industry (MechSustInd) is introduced to scientific community. The use of mechanical energy facilitate chemical transformations (mechanochemistry) has been rapidly gaining momentum across diverse areas science. Experimentally, strategies mechanically promote physico-chemical changes in matter are varied and include milling, extrusion techniques, pulsed ultrasonication, single-molecule...
Abstract Although mechanochemical synthesis is becoming more widely applied and even commercialised, greater basic understanding needed if the field to progress on less of a trial‐and‐error basis. We report that reaction in ball mill exhibits unusual sigmoidal feedback kinetics differ dramatically from simple first‐order for same solution. An induction period followed by rapid increase rate before decreases again as goes completion. The origin these found be cycle involving both chemical...
Working towards a fundamental description of mechanochemical reactions through the use classical molecular dynamics simulations. Capturing transfer molecules between two non-volatile crystals during events.
Twin screw extrusion (TSE) is demonstrated as an alternative synthetic method for preparing a prolific porous organic cage.
Abstract Compressibility is a fundamental property of all materials. For fluids, that is, gases and liquids, compressibility forms the basis technologies such as pneumatics hydraulics determines basic phenomena propagation sound shock waves. In contrast to gases, liquids are almost incompressible. If could be increased controlled, new applications in absorption result. Here, it shown dispersing hydrophobic porous particles into water gives aqueous suspensions with much greater...
Synthesis and use of the emblematic Wilkinson's catalyst by mechanochemistry was achieved.
Mechanochemical synthesis has the potential to change way in which chemistry is conducted, particularly with regard removing or dramatically reducing need for solvents. Recently, it been demonstrated that mechanochemistry can be carried out continuously and on large scale through use of twin-screw extrusion (TSE). TSE successfully applied cocrystals, metal organic frameworks (MOFs), deep eutectic solvents (DESs), complexes, condensation reactions. However, while provides a route...
Sonochemistry, i.e., the application of mechanical energy in form sound waves, has recently been recognised for its similarity to mechanochemistry and is now included under umbrella term mechanochemistry. Typically, due hypothesised cavitation mechanism, a liquid medium considered as necessity process take place result ultrasonic irradiation. In view this, condensation reactions between solid reagents complete absence solvent were carried out successfully by irradiation with importance...
Abstract Mechanochemistry has developed rapidly in recent years for efficient chemicals and materials synthesis. Twin screw extrusion (TSE) is a particularly promising technique this regard because of its continuous scalable nature. A key aspect TSE that it provides high shear mixing. Because the shear, potentially also offers way to delaminate 2‐D materials. Indeed, synthesis manor remains challenge their industrialization. Here, as proof‐of‐principle, automated, mechanochemical exfoliation...
Abstract A continuous, scalable, and solvent‐free method for the synthesis of various naphthalic imides perylene diimides (PDIs) using twin‐screw extrusion (TSE) is reported. Using TSE, were obtained quantitatively without need excess amine reactant or product purification. With good functional‐group tolerance, alkyl benzyl derived PDIs (incl. commercial dyes) in 50–99 % yield. Use K 2 CO 3 , enabled more difficult aniline‐derived PDIs. Furthermore, an automated continuous TSE process...