A5055772013- Carbon dioxide utilization in catalysis
- Catalysis for Biomass Conversion
- biodegradable polymer synthesis and properties
- Catalysis and Hydrodesulfurization Studies
- Synthetic Organic Chemistry Methods
- Supramolecular Self-Assembly in Materials
- Cancer-related molecular mechanisms research
- Catalytic Processes in Materials Science
- Chemical Synthesis and Analysis
- Advanced Polymer Synthesis and Characterization
- Polysaccharides Composition and Applications
- Mesoporous Materials and Catalysis
- Polydiacetylene-based materials and applications
- Hydrocarbon exploration and reservoir analysis
- Ocular Infections and Treatments
- Histone Deacetylase Inhibitors Research
- Enhanced Oil Recovery Techniques
- Nanocluster Synthesis and Applications
- Mechanisms of cancer metastasis
- Organoboron and organosilicon chemistry
- Supramolecular Chemistry and Complexes
- Diatoms and Algae Research
- Photopolymerization techniques and applications
- Ammonia Synthesis and Nitrogen Reduction
- Enzyme Catalysis and Immobilization
Queen's University Belfast
2024
The Third People's Hospital of Dalian City
2024
Tianjin University
2022
Hunan Provincial People's Hospital
2020
University of New Brunswick
2018-2019
University of Fredericton
2018-2019
Nanjing Tech University
2016-2017
Pharmaceutical Biotechnology (Czechia)
2016-2017
Sinopec (China)
2014
Dana (United States)
2010
Abstract The main cause of corneal blindness worldwide is keratitis, especially the infectious form caused by bacteria, fungi, viruses, and Acanthamoeba. key to effective management keratitis hinges on prompt precise diagnosis. Nevertheless, current gold standard, such as cultures scrapings, remains time-consuming frequently yields false-negative results. Here, using 23,055 slit-lamp images collected from 12 clinical centers nationwide, this study constructed a clinically feasible deep...
Telomerase reverse transcriptase (hTERT) overexpression, a hallmark of most cancers, drives tumorigenesis by enabling limitless replicative potential. Direct targeting hTERT is challenging, necessitating alternative strategies. Through genome-wide synthetic dosage lethality (SDL) screening in cancer models, including patient-derived organoids, we identify FTSJ3, an RNA 2'-O-methyltransferase, as critical vulnerability hTERT-overexpressing cells. FTSJ3 methylates telomeric repeat-containing...
A new protocol of internal Lewis pair enhanced H-bond (LPHBD) catalysis for ring opening polymerisation was developed using boronate-urea (BU) as a representative LPHBD combined with tertiary amines.
In reversible addition–fragmentation chain transfer (RAFT) polymerization, monomers are divided into "more-activated" (type-A1 monomer) and "less-activated" (type-A2 monomer). ring-opening polymerization (ROP), considered to fall electrophilically polymerizable (lactones carbonates, type-B1 nucleophilically (lactides type-B2 Developing a strategy copolymerize the four kinds of for formation asymmetric A2A1B1B2 type tetrablock quaterpolymers by one-pot sequential ROP RAFT is challenge....
A switch of an anionic ROP epoxides into a bifunctional H-bonding cyclic esters paved new avenue to one-pot, sequential, and block copolymerizations previously rare polyether-<italic>block</italic>-polyester copolymers.
1,1′-Binaphthyl-2,2′-diyl hydrogen phosphate (BNPH) catalyzed a controlled/living ROP of TMC through bifunctional activation mechanism, leading to end-functionalized PTMC and block polymers.
Abstract Mechanochemistry has developed rapidly in recent years for efficient chemicals and materials synthesis. Twin screw extrusion (TSE) is a particularly promising technique this regard because of its continuous scalable nature. A key aspect TSE that it provides high shear mixing. Because the shear, potentially also offers way to delaminate 2‐D materials. Indeed, synthesis manor remains challenge their industrialization. Here, as proof‐of‐principle, automated, mechanochemical exfoliation...
Furfural conversion via hydrodeoxygenation pathways on the Ru/Co3O4 surface is thoroughly investigated using density functional theory calculations. All feasible steps are identified. It found that an oxygen vacancy necessary to be generated in form of water for subsequent furfural. The furfural adsorbs at sites η2(C-O) pattern. product, 2-methylfuran, yielded hydrogenation into furyl-CH2O alkoxide intermediate, followed by C-O cleavage, and finally unsaturated furyl-CH2 species. This...
DFT calculations reveal that the oxygen-containing species prohibit hydrodeoxygenation of furfural on a Re/Pt bimetallic system.
An enzyme-mimetic model follows squalene hopene cyclase is success in catalysis of ROP δ-valerolactone solution at room temperature by a carboxylic “strong” acid.
Intramolecular H-bonding of <italic>ortho</italic>-amido group(s) tuned benzoic acid into strong Brønsted active in ring-opening polymerizations lactones and trimethylene carbonate at room temperature solutions.
Summary Tumor heterogeneity poses a significant challenge in combating treatment resistance. Despite Polo-like kinase 1 (PLK1) being universally overexpressed cancers and contributing to chromosomal instability (CIN), direct PLK1 inhibition hasn’t yielded clinical progress. To address this, we utilized the synthetic dosage lethality (SDL) approach, targeting PLK1’s genetic interactions for selective killing of tumor cells while mitigating heterogeneity-associated challenges. Employing...
Abstract Background Bladder cancer (BC) is the most common malignant tumor of urinary system. Increasing evidence indicates long non-coding RNAs (lncRNAs) play crucial roles in tumorigenesis, development, and progression. However, role TMPO antisense RNA 1 (TMPO-AS1) still need to be explored BC. Methods The lncRNA TMPO-AS1 expression was evaluated by bioinformatics analysis further validated qRT-PCR. Loss- gain-of- function assays were performed determine biological functions BC...
Abstract Background : The long non-coding RNA (lncRNA), LINC00518, is highly expressed in many human cancers and involved cancer progression. However, the potential function regulatory mechanism of LINC00518 cutaneous malignant melanoma (CMM) remain unclear. Methods :Short hairpin (shRNA) was used to silence HIF-1α, real-time PCR performed determine mRNA expression. Then, cell proliferation, colony formation, flow cytometric, scratch, transwell assays were examine influence silencing on...