A5100627699- Cancer-related molecular mechanisms research
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Cardiac Imaging and Diagnostics
- RNA Research and Splicing
- RNA modifications and cancer
- Advanced X-ray and CT Imaging
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Metabolism and Genetic Disorders
- Hepatitis C virus research
- TGF-β signaling in diseases
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Endoplasmic Reticulum Stress and Disease
- Gynecological conditions and treatments
- Vitamin D Research Studies
- Gout, Hyperuricemia, Uric Acid
- Hormonal Regulation and Hypertension
- Galectins and Cancer Biology
- Chemotherapy-induced organ toxicity mitigation
- Poxvirus research and outbreaks
- Neonatal and fetal brain pathology
Deyang Stomatological Hospital
2025
Beijing YouAn Hospital
2024
Capital Medical University
2024
Central South University
2014-2024
Third Xiangya Hospital
2012-2024
Fujian Medical University
2016
302 Military Hospital of China
2016
Risun (China)
2016
Fujian University of Traditional Chinese Medicine
2013
IHI Corporation (United States)
2013
To investigate the regulatory effect and mechanism of Vitamin D receptor (VDR) on mitochondrial function in renal tubular epithelial cell under diabetic status.
Abstract Long noncoding RNAs (lncRNAs) play a crucial role in progression of bladder urothelial carcinoma (BUC). However, the molecular mechanisms behind this have not been elucidated yet. Here, we found that lncRNA MAFG‐AS1 , which is highly expressed BUC, correlated with aggressive characteristics and poor prognosis BUC. We demonstrate can promote BUC proliferation, invasion, metastasis, epithelial‐mesenchymal transition vitro vivo. Mechanistically, direct binding to Hu antigen R (HuR)...
Abstract The long noncoding RNA, LINC00518 , is highly expressed in various types of cancers and involved cancer progression. Although promotes the metastasis cutaneous malignant melanoma (CMM), mechanism underlaying its effects on CMM radiosensitivity remains unclear. In this study, expression was significantly upregulated samples, levels were associated with poor prognosis patients CMM. Knockdown cells inhibited cell invasion, migration, proliferation, clonogenicity. LINC00518-mediated...
This study aims to investigate the level of health-promoting lifestyles and its influencing factors in Chinese patients with colorectal polyps. A total 169 polyps from three tertiary care hospitals Nanchong Deyang, China, were recruited. Data collected using Impact Health-Promoting Lifestyle Profile-II (HPLP-IIR), Colorectal Cancer Knowledge Questionnaire, Health Belief Scale, version Information Literacy Self-Rating a demographic questionnaire. Factors analyzed multiple linear regression...
As a screening index of diabetic kidney disease (DKD), urinary albumin/creatine ratio (UACR) is commonly used. However, approximately 23.3%-56.6% DKD patients with estimated glomerular filtration rate (eGFR) < 60 ml/min per 1.73 m2 are normoalbuminuric. Thus, biomarkers nonalbuminuric renal insufficiency in type 2 diabetes mellitus (T2DM) urgently needed. This cross-sectional study enrolled 209 T2DM normoalbuminuria whose duration was more than 5 years. The were classified into two groups,...
The RhoA/ROCK signaling pathway plays a significant role in transforming growth factor (TGF)-β1-mediated epithelial-mesenchymal transition (EMT). It remains unclear, however, whether the mediates TGF-β1-induced EMT by promoting dissolution of tight junctions (TJs) renal proximal tubular epithelial cells. In this study, we aimed to investigate association between TGF-β1-mediated Rho/ROCK and TJs cell line derived from human cells (HK-2 cells). HK-2 were treated with 5 ng/ml TGF-β1 for 0, 12,...
Abstract Growing evidence suggests that long non‐coding RNAs NORAD and miR‐205 play a significant role in regulating cancer progression metastasis. In this study, high expression of was firstly observed melanoma tissues human malignant cell lines, our aim to study the interaction them process invasion migration cells. NORAD, miR‐205, EGLN2 mRNA level MM cells detected by qRT‐PCR. situ hybridization (ISH) performed detect specimens. Effects on Prolyl hydroxylase 2 (EGLN2) explored western...
Abstract Vitamin D receptor was previously reported to be protective in acute kidney injury (AKI) with the mechanism unclear, while role of renal localized glutathione peroxidase 3 (GPX3) not illustrated. The present study aims investigate GPX3 as well its correlation vitamin D–vitamin (VD–VDR) ischemia–reperfusion (I/R)‐induced oxidative stress injury. We showed that expression and VDR were consistently decreased tissues I/R‐related AKI patients mice models. agonist paricalcitol could...
This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAM) integrity and cellular injury in cisplatin-induced acute kidney (CP-AKI).
Ischemia-reperfusion injury (IRI) is one of the major causes acute kidney (AKI). tRNA derived fragments (tRFs/tiRNAs) are groups small noncoding RNAs from tRNAs. To date, role tRFs/tiRNAs in renal IRI has not been reported. Herein, we aimed to investigate involvement occurrence and development ischemia-reperfusion-induced AKI.Moderate/severe mouse models were established by bilateral pedicle clamping. The tRF/tiRNA profiles healthy controls moderate/severe IRI-stressed tissues sequenced...
Objective: To investigate the causes of peritonitis in patients with peritoneal dialysis (PD) using continuous quality improvement (CQI) to develop effective interventions and reduce occurrence peritonitis. Methods: A control team consisting 10 members, including department head, four nephrologists nurses, all specialized PD care, head nurse, was established at Peritoneal Dialysis Center Third Xiangya Hospital Central South University. All occurring between 1 July 2010 31 December 2011...
We aimed to explore the anti-inflammatory effects of total alkaloids inRubus alceifolius Poir [corrected]. (TARAP) on non-alcoholic fatty liver disease, and investigate possible molecular mechanisms. A rodent disease (NAFLD) model was established by administration a modified high-fat diet ad libitum for 8 weeks. Rats were treated with polyene phosphatidylcholine (PP), TARAP low‑dose (0.72 g/kg body weight/day) high-dose (1.44 weight/day). The group control received distilled water. After...
This study aimed to reveal characteristics and clinical relevance of HBV intergenotypic recombinants. Serum samples 516 patients from Northern China were collected, including 131 with acute hepatitis B (AHB), 239 chronic (CHB), 146 acute-on-chronic liver failure (ACLF). Full-length genomes sequenced genotypes analyzed. Genotypes C, B, D, recombinants detected in 71.12% (367/516), 19.96% (103/516), 0.78% (4/516), 8.14% (42/516) the patients. The latter comprised 21 AHB, 10 CHB, 11 ACLF;...
Objective The evaluation of coronary stents by computed tomography (CT) remains difficult. We assessed the imaging performance a high-definition CT scanner (HDCT) comparing with conventional 64-row standard-definition (SDCT). Methods One hundred thirty-eight consecutive stented patients underwent angiography, among whom 66 were examined HDCT, and 72 SDCT (LightSpeed VCT XT; GE Healthcare, Waukesha, Wis). image quality score, inner stent diameter (ISD), radiation dose analyzed. All data...