A5038319130- Gut microbiota and health
- Drug-Induced Hepatotoxicity and Protection
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects of Natural Compounds
- Pharmacological Effects and Toxicity Studies
- Ginseng Biological Effects and Applications
- Dialysis and Renal Disease Management
- Phytochemistry and biological activity of medicinal plants
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemistry and Biological Activities
- Alzheimer's disease research and treatments
- Plant-derived Lignans Synthesis and Bioactivity
- Receptor Mechanisms and Signaling
- Amino Acid Enzymes and Metabolism
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- Tryptophan and brain disorders
- Alcohol Consumption and Health Effects
- Metabolism and Genetic Disorders
- Medicinal Plants and Neuroprotection
- Chemotherapy-induced organ toxicity mitigation
- Diet and metabolism studies
- Photoreceptor and optogenetics research
- Bone and Joint Diseases
Central South University
2016-2025
Xiangya Hospital Central South University
2016-2025
PharmacoGenetics (China)
2017-2025
National Clinical Research Center for Digestive Diseases
2019-2024
Sansure Biotech (China)
2024
The gut microbiota plays a pivotal role in the onset and development of diabetes its complications. Trimethylamine N-oxide (TMAO), microbiota-dependent metabolite certain nutrients, is associated with type 2 Diabetic kidney disease (DKD) one most serious microvascular However, whether TMAO accelerates DKD remains unclear. We tested hypothesis that DKD. A high-fat diet/low-dose streptozotocin-induced rat model was established, or without rats’ drinking water. Compared to normal rats, rats...
Status epilepticus, the most severe form of epilepsy, is characterized by progressive functional and structural damage in hippocampus, ultimately leading to development clinical appearance spontaneous, recurrent seizures. Although pathogenesis underlying epileptogenesis processes remains unclear, a substantial body evidence has shown that status epilepticus acts as an important initial factor triggering epileptogenesis. Notably, besides classical cell death mechanisms such apoptosis...
Abstract: Eucommia ulmoides Oliv. is a famous traditional Chinese medicine which exhibits anti-oxidative stress ability and neuro-protective effects. Aucubin the predominant component of Our present study intended to investigate aucubin’s potential protective effects on neurons against epilepsy in hippocampus by establishing lithium-pilocarpine induced status epilepticus (SE) rat model vivo. (at low dose high 5[Formula: see text]mg/kg 10[Formula: text]mg/kg, respectively) was administered...
Isoniazid (INH) is a highly effective single and/or combined first-line anti-tuberculosis (anti-TB) therapy drug, and the hepatotoxicity greatly limits its clinical application. INH-induced liver injury (INH-DILI) typical immune-mediated idiosyncratic drug-induced injury. Existing mechanisms including genetic variations in drug metabolism immune responses cannot fully explain differences susceptibility sensitivity to INH-DILI, suggesting that other factors may be involved. Accumulating...
Ginsenoside compound K (CK) is the main metabolite of protopanaxadiol-type ginsenosides and has been demonstrated to exert neuroprotective cognition-enhancing effects. The effects CK on cognitive function in vascular dementia (VD) not elucidated. Therefore, present study aims elucidate memory as well its potential mechanism VD rats. Sprague-Dawley rats were subjected Chronic Cerebral Hypoperfusion (CCH) by permanent bilateral common carotid artery occlusion (2VO). CCH induced neuronal damage...
The imbalance between the GABA-mediated inhibition and glutamate-mediated excitation is primary pathological mechanism of epilepsy. GABAergic glutamatergic neurotransmission have become most important targets for controlling Ginsenoside compound K (GCK) a main metabolic production ginsenoside Rb1, Rb2, Rc in intestinal microbiota. Previous studies show that GCK promoted release GABA from hippocampal neurons enhanced activity GABAA receptors. shown to reduce expression NMDAR attenuate...
This study aimed to investigate the potential role of gut microbiota in hepatotoxicity sodium valproate (SVP) and protective effect ginsenoside compound K (G-CK) administration against SVP-induced rats. Measurements 16S rRNA showed that SVP supplementation led a 140.749- 248.900-fold increase relative abundance Akkermansia muciniphila (A. muciniphila) Bifidobacterium pseudolongum (B. pseudolongum), respectively (p < 0.05). The A. was almost completely reversed by G-CK treatment. strongly...
Two new lignans, noreucol A (1) and (+)-epicycloolivil (2), along with seven known compounds (3–9) were isolated from the aqueous extract of Eucommia ulmoides Oliver. Compound 1 was a norlignan 2 an epimer at C-7 (+)-cycloolivil (3). Their structures elucidated by spectroscopic methods, absolute configurations determined conformational analysis DFT theoretic electronic circular dichroism spectra calculations. In addition, neuroprotective activity 1–3 against glutamate-induced HT-22 cells...
To investigate the dynamic expression and spatial distribution of P2X7 receptor in pilocarpine-induced epileptic rat hippocampus. Methods: Status epilepticus (SE) model rats was established by intraperitoneal injection with chloride lithium pilocarpine. Rat brain tissue hippocampus were collected at 1, 3, 7, 14, 28 days after SE. The protein detected Western blot. hippocampal sub-region analyzed immunohistochemistry. Results: Bilateral forelimb clonus appeared (33.9±12.3) min increased 1d...