A5066630141- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Gut microbiota and health
- Phytochemistry and biological activity of medicinal plants
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Computational Drug Discovery Methods
- Tryptophan and brain disorders
- Analytical Methods in Pharmaceuticals
- Pharmacogenetics and Drug Metabolism
- Lipid metabolism and biosynthesis
- Plant-based Medicinal Research
- Cholinesterase and Neurodegenerative Diseases
- Plant-derived Lignans Synthesis and Bioactivity
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Berberine and alkaloids research
- Alcohol Consumption and Health Effects
- Analytical Chemistry and Sensors
- Phytochemical Studies and Bioactivities
- Ziziphus Jujuba Studies and Applications
Xiangya Hospital Central South University
2019-2024
Central South University
2019-2024
National Clinical Research Center for Digestive Diseases
2019-2024
PharmacoGenetics (China)
2019-2024
University of Liverpool
2023
China Pharmaceutical University
2013-2017
State Key Laboratory of Natural Medicine
2014-2016
Indian Statistical Institute
2008
Polygonum multiflorum (PM) is a well‐known Chinese herbal medicine that has been reported to induce inflammation‐associated idiosyncratic liver injury. This study aimed identify the genetic basis of susceptibility PM‐drug‐induced injury (PM‐DILI) and develop biological markers for predicting risk PM‐DILI in humans. The major histocompatibility complex (MHC) regions 11 patients with were sequenced, all human leukocyte antigen (HLA)–type frequencies compared Han‐MHC database. An independent...
Isoniazid (INH) is a highly effective single and/or combined first-line anti-tuberculosis (anti-TB) therapy drug, and the hepatotoxicity greatly limits its clinical application. INH-induced liver injury (INH-DILI) typical immune-mediated idiosyncratic drug-induced injury. Existing mechanisms including genetic variations in drug metabolism immune responses cannot fully explain differences susceptibility sensitivity to INH-DILI, suggesting that other factors may be involved. Accumulating...
Background: Colorectal cancer (CRC) represents a third leading cause of cancer-related death worldwide. The reliable diagnostic biomarkers for detecting CRC at early stage is critical decreasing the mortality.Method: A conjunctive lipidomic approach was employed to investigate differences in plasma lipid profiles patients (n = 101) and healthy volunteers 52). Based on UHPLC-Q-TOF MS UHPLC-QQQ platforms, total 236 lipids were structurally detected. Multivariate data analysis conducted...
Background Phytochemical-mediated alterations in P-glycoprotein (P-gp) activity may result herb-drug interactions by altering drug pharmacokinetics. Shengmai-san, a traditional Chinese herbal medicine composed Panax Ginseng, Ophiopogon Japonicus, and Schisandra Chinensis, is routinely being used for treating various coronary heart diseases. In our previous studies, Lignans Extract (SLE) was proved as strong P-gp inhibitor, herein, the compatibility of Shengmai-san studied investigating...
AbstractTwo different models of diffusion - demic and cultural have been proposed as an explanation for the spread languages. Recent studies shown that in some cases dispersal language was due to while others it is purely process acculturation. There are four major linguistic families India which largely their own geographic domain. However, there a few situations populations affiliated cohabit. For example, we find Indo-European Dravidian tribal core/peripheral areas Mundari Austro-Asiatic...
Oplopanax elatus (Nakai) Nakai is an oriental herb, the polyyne-enriched fraction of which (PEFO) showed anticolorectal cancer (anti-CRC) effects. Other concomitant components, are inevitably bio-transformed by gut microbiota after oral administration, might be interfere with pharmacodynamics polyynes. However, influence human on molecules from O. possessing anticancer activity yet unknown. In this study, compounds in PEFO and incubated were analyzed tentatively identified HPLC-DAD-QTOF-MS....
Imprinted genes are often identified as key players in the etiology and prognosis of many tumors; however, role they play colon cancer remains unclear. Along with development big data analysis came discovery a wealth genetic prognostic factors, like microsatellite instability for cancer, which need to be taken into consideration when evaluating new biomarkers disease.We systematically mined public databases find recurrence free survival (RFS)-related imprinted patients on mRNA level by...