A5000537173- RNA modifications and cancer
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Probiotics and Fermented Foods
- Inflammatory Bowel Disease
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Urological Disorders and Treatments
- Medical Research and Treatments
- Lipid metabolism and disorders
- HIV Research and Treatment
- Immune Response and Inflammation
- Pancreatic and Hepatic Oncology Research
- HIV/AIDS Research and Interventions
- Drug Transport and Resistance Mechanisms
- interferon and immune responses
- Gastric Cancer Management and Outcomes
- Traditional Chinese Medicine Studies
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
Kunming University of Science and Technology
2024
First People's Hospital of Yunnan Province
2024
Sun Yat-sen University
2022-2024
China Agricultural University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Xinjiang Medical University
2024
Wangjing Hospital of China Academy of Chinese Medical Sciences
2024
Binzhou University
2014-2024
Binzhou Medical University
2024
Xiangya Hospital Central South University
2019-2022
Abstract Background Ketosis is a common metabolic disease during the transition period in dairy cattle, resulting long-term economic loss to industry worldwide. While genetic selection of resistance ketosis has been adopted by many countries, and biological basis underlying poorly understood. Results We collected total 24 blood samples from 12 Holstein cows, including 4 healthy 8 ketosis-diagnosed ones, before (2 weeks) after (5 days) calving, respectively. then generated RNA-Sequencing...
Interestingly, some protein domains are intrinsically disordered (abbreviated as IDD), and the disorder degree of same may differ in different contexts. However, evolutionary causes biological significance these phenomena unclear. Here, we address issues by genome-wide analyses functional features IDDs 1,870 species across three superkingdoms. As result, there is a significant positive correlation between proportion organism complexity with interesting exceptions. These be due to high...
Chaihu-Shugan-San (CSS) is a traditional botanical drug formula often prescribed to treat depression in oriental countries, but its pharmacotherapeutic mechanism remains unknown. It was recently reported that CSS alters the composition of intestinal microflora and related metabolites such as bile acids (BAs). Since affects physiological functions brain through gut-microbiota-brain axis, herein we investigated whether altered BA levels, gut microflora, depression-like symptoms chronic...
Introduction Dietary fiber plays a crucial role in maintaining gastrointestinal health. However, its protective effects on the intestinal health of calves remain to be fully elucidated. This study aimed investigate impact dietary supplementation microbiota pre-weaned and potential modulating microbial metabolic pathways. Methods A randomized controlled trial was conducted, enrolling 135 that were randomly assigned into three groups: (1) inulin supplementation, (2) psyllium husk powder (PHP)...
Non-small cell lung cancer (NSCLC) is associated with high mortality and morbidity rates. Despite major progress of treatment NSCLC over the past few decades, prognosis advanced poor, 5-year survival rates ranging from 2 % to 13 %. Belamcanda chinensis a traditional Chinese medicine used promote blood circulation, reduce swelling, heal ulcers, disperse lumps tumors, resolve stasis. In present study, anti-proliferative pro-apoptotic effects potential mechanisms action extract (BCE) in SPC-A1...
Qing-Kai-Ling (QKL) oral liquid, evolving from a classical Chinese formula known as An-Gong-Niu-Huang pills, is well-established treatment for pneumonia with its mechanism remaining muddled. Studies have shown that the regulation of both intestinal flora and host-microbiota co-metabolism may contribute to preventing treating pneumonia. The study aimed investigate potential by which QKL alleviates perspective 'microbiota-metabolites-host' interaction.We evaluated therapeutic effects on...
Imprinted genes are often identified as key players in the etiology and prognosis of many tumors; however, role they play colon cancer remains unclear. Along with development big data analysis came discovery a wealth genetic prognostic factors, like microsatellite instability for cancer, which need to be taken into consideration when evaluating new biomarkers disease.We systematically mined public databases find recurrence free survival (RFS)-related imprinted patients on mRNA level by...
1. Bupleuri Radix (BR) is a herbal medicine traditionally used orally in oriental countries, which inevitably comes into contact with the intestinal microbiota. However, whether gut microbiota contribute to biotransformation of BR, and/or formation pharmacologically active compounds remains unknown.2. In this study, main saikosaponins (SAPs) Bupleurum (including saikosaponin a, b1, b2, c, d, f, h) and BR extract (BRE) were individually incubated human fecal suspensions (HFS), metabolic time...
BACKGROUND:Multiple sclerosis (MS) is an autoimmune disease causing multifocal demyelination and axonal injuries in the central nervous system (CNS). Toll-interleukin-1 receptor (TIR)-domain containing adaptor protein-inducing interferon beta (TRIF) important protein for Toll-like receptors (TLRs) can modulate immune response via regulating cytokine secretion. This study investigated potential function of TRIF MS mice small interference RNA (siRNA). MATERIAL AND METHODS:Isolated mouse...
RNAs (circRNAs) play critical roles in many diseases, including atherosclerosis (AS). However, the role and underlying mechanism of circ_0002984 AS remain unclear. Vascular smooth muscle cells (VSMCs) treated with oxidized low-density lipoprotein (ox-LDL) were used as a cell model. Quantitative real-time polymerase chain reaction was conducted to detect expression circ_0002984, miR-181b-5p vascular endothelial growth factor A (VEGFA). Cell proliferation evaluated by 3-(4,...
Diet is an important factor for many diseases. Previous studies have demonstrated that several diets had remarkable effects on bile acid (BA) homeostasis, but no comprehensive information both genders has been reported. Therefore, the current study characterized nine most used laboratory animal fed to of mice a comparable evaluation topic. The results revealed marked gender difference BA homeostasis ubiquitous in various diets, and mice, atherogenic calorie-restricted followed by chow...
Chemoresistance remains a significant challenge in colorectal cancer (CRC) treatment, necessitating deeper understanding of its underlying mechanisms. HOXC11 has emerged as potential regulator various cancers, but role CRC chemoresistance unclear.
This study aims to investigate the therapeutic effect and mechanism of Panax notoginseng saponins(PNS) on diabetic kidney disease(DKD) based network pharmacology, molecular docking, animal experiments. Network pharmacology was employed screen potential targets, STRING build protein-protein interaction network. Gene Ontology(GO) Kyoto Encyclopedia Genes Genomes(KEGG) enrichment analyses were carried out for core targets screened out, a ″components-targets-pathways″ visualization constructed...
Diabetic nephropathy (DN) is a prevalent complication and serious microvascular of diabetes mellitus. After previous studies, we found that phenylethanol glycosides (CPhGs) derived from
Background: Even with long-term complete suppression of the virus through Antiretroviral therapy (ART), people infected HIV cannot attain optimal immune reconstitution. This phenomenon is called reconstitution deficiency, there are no effective therapeutic interventions for deficiency in modern medicine. Objective: To evaluate efficacy and safety ART Shenling Guben Granules Traditional Chinese medicine boosting immunological compared alone. Methods: was a randomized, double-blind,...