A5045760757- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Vascular Malformations Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Toxin Mechanisms and Immunotoxins
- Intracerebral and Subarachnoid Hemorrhage Research
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Aortic aneurysm repair treatments
- Microbial metabolism and enzyme function
- Meningioma and schwannoma management
- Cerebrovascular and genetic disorders
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Cerebrovascular and Carotid Artery Diseases
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Rabies epidemiology and control
- Multiple Myeloma Research and Treatments
- Cervical and Thoracic Myelopathy
- Cancer Immunotherapy and Biomarkers
Central South University
2012-2024
Xiangya Hospital Central South University
2010-2024
Huazhong University of Science and Technology
2013
MicroRNAs (miRNAs) act as key regulators of multiple cancers. miR‐329 functions a tumor suppressor in some malignancies. However, its role neuroblastoma remains poorly understood. We found that was decreased metastatic tissues compared with matched primary tissues. Forced overexpression substantially suppressed cell proliferation, colony formation, migration, and invasion cells. Lysine‐specific demethylase 1 (KDM1A) to be target miR‐329. Furthermore, down‐regulation KDM1A by shRNA performed...
Chaihu-Shugan-San (CSS) is a traditional botanical drug formula often prescribed to treat depression in oriental countries, but its pharmacotherapeutic mechanism remains unknown. It was recently reported that CSS alters the composition of intestinal microflora and related metabolites such as bile acids (BAs). Since affects physiological functions brain through gut-microbiota-brain axis, herein we investigated whether altered BA levels, gut microflora, depression-like symptoms chronic...
Objective: Flow diverter stents (FDSs) have attracted interest for intracranial aneurysm (IA) treatment; however, occlusion of side branches and related complications been reported. This study aimed to investigate the effects FDSs in IA management when different arteries are covered. Materials methods A cross-sectional was conducted using PUBMED, Embase, Web Science, Cochrane databases include randomized or non-randomized comparative designed studies from January 2000 August 2022 which...
Strangles is a highly contagious respiratory disease of equids caused by the bacterium Streptococcus equi subspecies equi.To identify cause an outbreak strangles that occurred on donkey farms within Shandong Province China and determine prevalence disease.Cross-sectional.Samples were taken from clinically affected animals to measure population donkeys at six intensive in SeM type isolate recovered animals. Diagnosis was confirmed bacterial isolation, biochemical tests PCR. Epidemiological...
Abstract Objective The Tubridge flow diverter (TFD) was recently developed to treat intracranial aneurysm (IA). In this study, we aimed assess the safety and efficacy of novel device. Methods A retrospective cohort consecutive patients with IA recruited between June 2017 February 2022. studied outcomes were perioperative complications, clinical quality life, angiographic occlusion. Multivariate logistic regression performed explore potential predictors stroke events comprehensive literature...
Brain ischemic injury is associated with clinical emergencies such as acute and hemorrhagic stroke, head trauma, prolonged severe hypotension cardiac arrest. Ischemic preconditioning (IPC) the most powerful endogenous mechanism against injury. However, majority of IPC treatments are invasive thus impractical in setting. Identifying neuroprotective induced by important for developing new strategies to reduce stroke severity. Zinc finger protein 667 (ZNF667) a novel zinc that upregulated...
A 33-year-old male presented with a thoracic spinal intramedullary meningioma manifesting as bilateral asymmetric progressive weakness in the lower extremities. Preoperative magnetic resonance imaging (MRI) showed an mass at T1–T3 level. Intraoperative inspection found that cord was markedly swollen normal surface while dural attachment not confirmed. Gross total removal of tumor achieved. The morphologic and immunohistochemical findings were compatible diagnosis meningioma. Postoperatively,...
Intracranial aneurysm (IA) is a cerebrovascular disorder in which abnormal dilation of blood vessel results from weakening the wall. The may rupture, leading to subarachnoid hemorrhage with severe outcomes. This study was conducted identify genetic factors involved etiology IA. Whole-exome sequencing performed three IA-aggregate families candidate variants. Further association studies variants were among sporadic cases and controls. Bioinformatic analysis used predict functions genes Twenty...
Intracranial aneurysm (IA) is a complex disease caused by genetic and environmental factors. Evidence indicates that inflammation plays an important role in IA occurrence. We aimed to explore the associations between inflammatory cytokine gene polymorphisms Chinese population. This study enrolled 768 participants of Han ethnicity, including 384 patients with healthy individuals. Sixteen single nucleotide (SNPs) IL1, IL6, IL12, TNF-α genes were genotyped using Sequenom MassARRAY platform....
Dysregulation of retinoblastoma (Rb) signaling pathway have been established as a requirement for glioblastoma (GBM) initiation and progression, which suggests that blockade CDK4/6-Rb axis GBM treatment. Palbociclib, selective inhibitor the cyclin-dependent kinases CDK4/6, has applied breast cancer However, its efficacy against not well clarified. Here, effects CDK4/6 inhibitors on various kinds cell lines are investigated functional mechanisms identified. Data showed cells with diverse PTEN...
To investigate the in vitro and vivo anticancer efficacy of immunotoxin DTAT DTATEGF against globlastoma multiforme.The cytotoxicity was measured using MTT assay. In studies were performed which 18 nude mice randomly divided into 3 groups glioma xenograft intracranial mouse model constructed with U87-luc cell line human glioma. Then 1 μg DTAT, or DTATEGF, a control protein Bickel3 delivered intracranially by convection-enhanced delivery (CED) via an osmotic minipump. The brain tumor...
Background and Purpose Stroke is a serious fatal disabling disease. Stroke-associated pneumonia (SAP) the most common complication of stroke, which may further aggravate stroke. The prevention early prediction SAP key clinical strategy. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) involved in pneumonia, while its relationship with has yet to be determined. Therefore, we investigated predictive value 15-PGDH for visualized their relationship. Methods patients were recruited divided into...
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease caused by intracranial aneurysm (IA) rupture. Lysyl oxidase (LOX) family genes (LOX-like [LOXL] 1-4) have roles in collagen cross-linking the extracellular matrix (ECM) and may be associated with IA We aimed to explore association between LOX polymorphisms risk of aSAH.This case-control study included 2 cohorts: 133 single ruptured 115 unruptured patients, 65 multiple 71 patients. Genotyping 27 nucleotide (SNPs) was...
Purpose Intracranial aneurysms (IA) comprise a multifactorial disease with unclear physiological mechanisms. The lysyl oxidase ( LOX ) family genes , LOX–like 1–4 plays important roles in extracellular matrix (ECM) reconstruction and has been investigated terms of susceptibility to IA few populations. We aimed determine whether polymorphisms are associated Chinese population. Methods This case-control study included 384 patients healthy individuals without (controls). genotyped 27 single...
A small population of neurons in the hypothalamus is known to promote food intake by releasing inhibitory agouti‑related peptide (ARP) and neuropeptide Y broad postsynaptic areas. Acute ablation ARP adult mice leads rapid loss appetite development an anorexic phenotype. Recent studies have suggested that removes critical inhibition neurons, resulting hyperexcitation selected downstream neurons. Left uncontrolled, this neuronal hyperactivation hypothesized induce starvation. However, cellular...
To discuss the clinical features of chronic subdural hematoma (CSDH) in different age groups.A total 417 patients with CSDH were divided into 3 groups: 0 to 39, 40 59 and elder than 60 years. We analyzed groups, including sex, trauma history, potential hemorrhage factors, symptoms interval, encephalatrophy, onset symptom volume.The incidence trauma, consciousness disorders paralysis increased age, while intracranial hypertension seizures decreased (P<0.001). The interval group was longer...
Genetic factors play important roles in the development of intracranial aneurysm (IA). Rare RNF213 variants have been identified as being susceptible to Moyamoya disease (MMD), non-MMD artery stenosis/occlusion disease, and other vascular disorders. This study aimed investigate association between rare risk IA a Chinese population.We recruited 174 patients with for target exome sequencing. Information on control subjects was obtained from 1,000 Genome Project GeneSky in-house database. After...