A5100624421- Venomous Animal Envenomation and Studies
- Virus-based gene therapy research
- Toxin Mechanisms and Immunotoxins
- Angiogenesis and VEGF in Cancer
- Immune Response and Inflammation
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Herpesvirus Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Immunotoxicology and immune responses
- Viral Infectious Diseases and Gene Expression in Insects
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Cancer-related gene regulation
- Biopolymer Synthesis and Applications
- Drug-Induced Hepatotoxicity and Protection
- Mast cells and histamine
- Membrane Separation Technologies
- Cancer Research and Treatments
- Phytochemistry and Biological Activities
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Peking Union Medical College Hospital
2017-2025
Nanchang University
2024
Shanghai Ninth People's Hospital
2019-2024
Nanjing University of Chinese Medicine
2019-2024
Second People's Hospital of Yunnan Province
2020-2024
Yunnan University
2024
National Institutes for Food and Drug Control
2010-2024
Jinan Central Hospital
2018-2024
Shandong First Medical University
2024
Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin (NHL). Pterostilbene, a natural dimethylated analog resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, best our knowledge, there no study effects pterostilbene upon hematological malignancies. Herein, we report antitumor activity mechanism against DLBCL cells both in vitro vivo . We found that treatment...
Abstract A microfluidic multi-organ chip emulates the tissue culture microenvironment, enables interconnection of organ equivalents and overcomes interspecies differences, making this technology a promising powerful tool for preclinical drug screening. In study, we established chip-based model that enabled non-contact cocultivation liver spheroids renal proximal tubule barriers in connecting media circuit over 16 days. Meanwhile, 14-day repeated-dose systemic administration cyclosporine...
We have recently reported the identification of kringle 1-5 (K1-5) plasminogen as a potent and specific inhibitor angiogenesis tumor growth. Here, we show that K1-5 bound to endothelial cell surface ATP synthase triggered caspase-mediated apoptosis. Induction apoptosis involved sequential activation caspases-8, -9, -3. Administration neutralizing antibodies directed against alpha- beta-subunits cells attenuated these caspases. Furthermore, inhibitors caspases-3, -8, -9 also remarkably...
We used cell-free culture filtrate of Pseudomonas aeruginosa as a reducing mediator AgNO3 to silvernanoparticles (AgNPs) and possibly potential anticancer agent against thyroid cancer cells (TPC1). The bio-generation AgNPs was firmly established by taking UV spectrum at 380–500 nm wavelength. Fourier transform analysis reveals the association alcohol, phenol aromatic functional groups with P. synthesized (Ps-AgNPs). By observing under transmission electron microscopy (TEM), size structure...
Abstract Background Osteoarthritis (OA) is a common degenerative joint condition marked by inflammation and cartilage breakdown. Currently, there dearth of treatment medications that can clearly slow the course OA. Glaucocalyxin A (GLA) diterpene chemical identified extracted from Rabdosia japonica with antithrombotic, anticoagulant, anti-tumor, anti-inflammatory, anti-oxidant, other pharmacological properties. Previous research has linked to abnormalities in homeostasis extracellular matrix...
Background Recent studies have suggested that mast-cell activation and inflammation are important in obesity diabetes. Plasma levels of mast cell proteases the activator immunoglobulin E (IgE) may serve as novel inflammatory markers associate with risk pre-diabetes diabetes mellitus. Methods Results A total 340 subjects 55 to 75 years age were grouped according American Diabetes Association 2003 criteria normal glucose tolerance, pre-diabetes, The Kruskal-Wallis test demonstrated significant...
Substantial evidence indicates that the alteration of cellular redox status is a critical factor involved in cell growth and death results tumourigenesis. Cancer cells have an efficient antioxidant system to counteract increased generation ROS. However, whether this ability survive high levels ROS has important role metastasis tumours not well understood. Glutaredoxin 3 (GLRX3), also known as TXNL2, Grx3 PICOT, maintains low level ROS, thus contributing survival several types cancer. little...
The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound combination with hematoporphyrin monomethyl ether (HMME). optimum frequency was determined 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. apoptotic rate, reactive oxygen species concentration decreased mitochondrial membrane potential (MMP) were analyzed flow cytometry. Morphological changes...
The five-paced pit viper (Deinagkistrodon acutus), endemic to China and northern Vietnam, is responsible for most snakebites in the Chinese territory. Antivenom produced from horses main treatment snakebites, but it may cause numerous clinical side effects have other disadvantages involved their production such as welfare of animals. present study was conducted aiming develop an alternative antibody (IgY) egg yolk leghorn chickens immunized with snake venom. IgY white previously...
Background: The monkey is a primary species used in toxicological research. However, the failures of preclinical studies to predict life-threatening "cytokine storm", which, for instance, rapidly occurred six healthy volunteers with CD28 superagonist monoclonal antibody (mAb) TGN1412 first-in-human phase I clinical trial, have emphasized need clarify differences between human and immune systems.
Abstract Background Perifosine, an alkylphospholipid tested in phase II clinical trials, modulates the extrinsic apoptotic pathway and cooperates with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to augment apoptosis. The current study focuses on revealing mechanisms by which perifosine enhances TRAIL-induced Results combination of TRAIL was more active than each single agent alone inducing apoptosis head neck squamous cell carcinoma cells inhibiting growth xenografts....