A5063399174- Veterinary medicine and infectious diseases
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Free Radicals and Antioxidants
- Toxin Mechanisms and Immunotoxins
- Humic Substances and Bio-Organic Studies
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Antibiotics Pharmacokinetics and Efficacy
- Natural product bioactivities and synthesis
- Antioxidant Activity and Oxidative Stress
- Genomics, phytochemicals, and oxidative stress
- Photochemistry and Electron Transfer Studies
- Electron Spin Resonance Studies
- Nanoplatforms for cancer theranostics
- Phytochemistry and Biological Activities
- Synthesis and biological activity
- Clostridium difficile and Clostridium perfringens research
- Metal complexes synthesis and properties
- Biochemical effects in animals
- Immunotherapy and Immune Responses
- Plant Virus Research Studies
- Immune Response and Inflammation
- Poxvirus research and outbreaks
- Cell Adhesion Molecules Research
South China Agricultural University
2016-2025
Key Laboratory of Guangdong Province
2020-2024
University Hospital Heidelberg
2023-2024
Heidelberg University
2023-2024
German Cancer Research Center
2023-2024
University of California, San Francisco
2016-2020
Jilin University
2005-2009
Anthropogenic environments have been implicated in enrichment and exchange of antibiotic resistance genes bacteria. Here we study the impact confined controlled swine farm on temporal changes gut microbiome resistome veterinary students with occupational exposure for 3 months. By analyzing 16S rRNA whole metagenome shotgun sequencing data tandem culture-based methods, show that shapes students, resulting potentially pathogenic taxa antimicrobial genes. Comparison students' microbiomes...
Chamomile has long been used as a medicinal plant due to its antioxidative and anti-inflammatory activity. Apigenin-7-O-glucoside (AG) is one of the major ethanol extract components from chamomile; however, underlying mechanism remains unclear.In this study, antioxidant potential activities AG were analysed compared with those trolox. We demonstrate protective effects on free radical-induced oxidative damage DNA, proteins erythrocytes. Flow cytometry assay was detect ROS production....
Abstract Molecular perovskites have demonstrated great potential for ferroelectrics and nonlinear optics; however, their charge transport properties optoelectronics rarely been explored. Here, understanding of behavior molecular perovskite under X‐ray excitation based on centimeter‐scale TMCM‐CdCl 3 (TMCM + , trimethylchloromethyl ammonium) single crystal is demonstrated. The fabricated from an aqueous solution exhibits a large bandgap 5.51 eV, with the valence band maximum mainly dominated...
A systemic treatment strategy is urgently demanded to suppress the rapid growth and easy metastasis characteristics of breast cancer. In this work, a chimeric peptide-engineered self-delivery nanomedicine (designated as ChiP-CeR) for photodynamic-triggered cancer immunotherapy by macrophage polarization. Among these, ChiP-CeR composed photosensitizer chlorine e6 (Ce6) TLR7/8 agonist lmiquimod (R837), which further modified with tumor matrix targeting peptide (Fmoc-K(Fmoc)-PEG
Abstract The major objective was to measure the trolox (6‐hydroxy‐2,5,7,8‐tetramethylchroman‐2‐carboxylic acid) equivalent antioxidant capacity (TEAC) of carbazole derivatives (Ar 2 NHs) by means scavenging 2,2′‐diphenyl‐1‐picrylhydrazyl (DPPH) and 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonate) radical cation (ABTS +· ). Ar NHs included phenoxazine (PozNH), phenothiazine (PtzNH), iminostilbene (IsbNH) diphenylamine (DpaNH), TEAC trolox, α‐tocopherol (TocH), l ‐ascorbic acid (VC)...
De novo design provides an attractive approach to test the mechanism by which metalloproteins define geometry and reactivity of their metal ion cofactors. While there has been considerable progress in designing proteins that bind transition ions including iron-sulfur clusters, tetranuclear clusters with oxygen-rich environments not accomplished. Here, we describe consisting four Zn
In this study, we designed and synthesized a series of pleuromutilin derivatives containing thiazole. The in vitro antimicrobial efficacy these compounds was examined by using four strains. Compared with tiamulin (MIC = 0.25 μg/mL), compound 14 exhibited potency inhibiting MRSA growth 0.0625 μg/mL) derivatives. Meanwhile, the time-killing kinetics further demonstrated that could efficiently inhibit growth. After exposure at 4 × MIC, postantibiotic effect (PAE) 1.29 h. Additionally,...
Abstract Objectives To evaluate the in vitro and vivo antimicrobial activity of pleuromutilin derivatives modified with C14 side-chain against Streptococcus suis. Methods determine minimum inhibitory concentrations (MICs) 268 modifications S. suis ATCC 43 765 using broth dilution method. Derivative B43, B49, B52, B53 B54, which exhibited better activity, were selected for further investigation their antibacterial effect, cytotoxicity, effect. Results Determination five clinical strains (n =...
As an abundant ingredient in coffee, chlorogenic acid (CGA) is a well-known antioxidant. Although some works have dealt with its radical-scavenging property, the present work investigated protective effects of CGA on oxidation DNA and hemolysis human erythrocytes induced by 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH) means chemical kinetics. The inhibition period (tinh) derived from effect erythrocyte was proportional to concentration, tinh = (n/Ri)[CGA], where Ri refers...
Icariin (2-(4'-methoxylphenyl)-3-rhamnosido-5-hydroxyl-7-glucosido-8-(3'-methyl-2-butylenyl)-4-chromanone) is a flavonoid with rhamnose as ligand. It the major component in Herba epimedii, widely used for treatment of atherosclerosis and neuropathy Chinese traditional medicine, its antioxidative property has attracted much scientific interest. The objective this work to determine effect icariin against oxidative DNA damage induced by 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). was...
A method based on accelerated solvent extraction combined with rapid-resolution LC-MS for efficient extraction, rapid separation, online identification and accurate determination of the saikosaponins (SSs) in Radix bupleuri (RB) was developed. The RB samples were extracted by using 70% aqueous ethanol v/v as solvent, at a temperature 120 degrees C pressure 100 bar, 10 min static time three cycles. Rapid-resolution LC separation performed C(18) column gradient elution water (containing 0.5%...