A5100689299- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Meat and Animal Product Quality
- MicroRNA in disease regulation
- Chronic Myeloid Leukemia Treatments
- Nanoparticle-Based Drug Delivery
- Acute Myeloid Leukemia Research
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Cancer therapeutics and mechanisms
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- Lung Cancer Treatments and Mutations
- Pharmacogenetics and Drug Metabolism
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Breast Cancer Treatment Studies
- Cancer-related Molecular Pathways
- Aquaculture Nutrition and Growth
- Cancer Treatment and Pharmacology
China-Japan Friendship Hospital
2025
First Hospital of China Medical University
2017-2025
China Medical University
2013-2025
University of California, San Diego
2025
Air Force Medical University
2025
Chinese Academy of Agricultural Sciences
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
Huazhong University of Science and Technology
2007-2024
National Cancer Center
2024
Nanjing Agricultural University
2013-2024
Abstract Oxaliplatin is important for the clinical treatment of colorectal cancer and other gastrointestinal malignancies, but tumour resistance limiting. Several oxaliplatin transporters were previously identified their relative contributions to determining responses cell sensitivity remains unclear. We studied associations between expression transporter candidate genes patient response oxaliplatin, then experimentally verified found with MRP2 in models human cancer. Among 18 genes, was...
<h3>Background</h3> To understand the involvement of micro-RNA (miRNA) in development and progression oesophageal squamous cell carcinoma (ESCC), miRNA profiles were compared between tumour corresponding non-tumour tissues. <h3>Methods</h3> miRCURY LNA array was used to generate expressing profile. Real-time quantitative PCR applied detectthe expression <i>miR-375</i> ESCC samples its correlation with insulin-like growth factor 1 receptor (IGF1R). Methylation-specific study methylation...
Systems pharmacology is an emerging field that integrates systems biology and to advance the process of drug discovery, development understanding therapeutic mechanisms. The aim present work highlight role plays across traditional herbal medicines discipline, which exemplified by a case study botanical drugs applied in treatment depression. First, based on critically examined clinical knowledge, we propose large-scale statistical analysis evaluate efficiency herbs used medicines. Second,...
CALGB 40603 (NCT00861705), a 2 × randomized phase II trial, demonstrated that adding carboplatin or bevacizumab to weekly paclitaxel (wP) followed by doxorubicin and cyclophosphamide significantly increased the pathologic complete response (pCR) rate in stage II-III triple-negative breast cancer. We now report long-term outcomes (LTOs) correlative science end points.The Kaplan-Meier method was used estimate LTOs 443 patients who initiated study treatment. Log-rank tests Cox proportional...
Abstract Introduction The prognosis of relapsed or refractory mature T‐ and natural killer (NK)‐cell lymphoma remains dismal. Novel agents are urgently needed to improve the outcomes for this population. Methods In phase 2, multicenter, open‐label, single‐arm study (NCT03776279), authors report efficacy safety liposomal mitoxantrone (Lipo‐MIT) monotherapy in patients with NK‐cell lymphoma. Lipo‐MIT was administered intravenously at 20 mg/m 2 once every 4 weeks. primary end points were...
Significance Acute myeloid leukemia (AML) consists of a group hematopoietic malignancies with considerable diversities in clinical and biological features. Recently, not only genetic abnormalities but also “oncometabolites,” such as 2-hydroxyglutarate (2-HG), have been found to play role driving AML pathogenesis serve potential disease markers. In this study on large cohort AML, we that the serum 2-HG level was increased 62 367 (17%) cases distinct hematologic Survival analysis performed 234...
Objective Long noncoding RNAs ( lncRNAs ) are an important class of genes involved in various biological functions; however, knowledge about osteoarthritis OA is limited. Therefore, the present study aimed to identify which expressed versus normal cartilage. Methods To specifically cartilage, expression cartilage was compared with that using microarray analysis. The identified differences were validated by real time polymerase chain reaction RT‐PCR ). Furthermore, several key mRNAs...
<b><i>Objective:</i></b> This study examined the expression of renal phospholipase A<sub>2</sub> receptor (PLA<sub>2</sub>R) in idiopathic and secondary membranous nephropathy (MN). <b><i>Methods:</i></b> Patients with biopsy-proven MN non-MN were enrolled. Renal PLA<sub>2</sub>R was using an anti-PLA<sub>2</sub>R antibody (anti-PLA<sub>2</sub>R-Ab), circulating...
Myocardial infarction (MI) is caused by the formation of plaques in arterial walls, leading to a decrease blood flow heart and myocardium injury as result hypoxia. Ferroptosis crucial event myocardial injury, icariin (ICA) exerts protective effects against injury. Here, we investigated mechanism ICA hypoxia/reoxygenation (H/R)-induced ferroptosis cardiomyocytes. H9C2 cells were subjected H/R induction. The content lactate dehydrogenase levels oxidative stress intracellular ferrous ion Fe2+...
Berberine (BBR) is an isoquinoline alkaloid, which has been used in the treatment of intestinal mucositis. However, BBR on chemotherapy-induced mucositis cancer patients remains largely unknown. Here, we investigated effect induced by 5-fluorouracil (5-Fu) using rat model. We detected degree mucosal damage and inflammatory response 5-Fu treated rats with or without administration, changes fecal metabolites gut microbiota 1H NMR spectroscopy 16S rRNA. The mechanism was further explored...
Breast cancer is the leading cause of death in women. Chemotherapy to inhibit proliferation cells considered be most important therapeutic strategy. The development long-circulating PEG and targeting liposomes a major advance drug delivery. However, techniques used liposome preparation mainly involve conventional liposomes, which have short half-life, high concentrations liver spleen reticuloendothelial system, no active targeting.Four kinds paclitaxel were prepared characterized by various...
Experimental and observational research suggests that combined epidural-general anesthesia may improve long-term survival after cancer surgery by reducing anesthetic opioid consumption blunting surgery-related inflammation. This study therefore tested the primary hypothesis improves in elderly patients.
ARID1A is among the most commonly mutated tumor suppressor genes in hepatocellular carcinoma (HCC). In this study, we conduct a CRISPR-Cas9 synthetic lethality screen using ARID1A-deficient HCC cells to identify approaches treat patients harboring deficiency. This strategy reveals that survival of these highly dependent on related tricarboxylic acid (TCA) cycle. Mechanistically, loss represses expression key glycolysis-related gene PKM, shifting cellular glucose metabolism from aerobic...
The therapeutic administration of Lactobacillus paracasei GY-1 attenuates the physical, behaviral, and intestinal toxicity colchicine, enhances effect for gout flares when combined with colchicine.
As a natural anti‐cancer alkaloid extracted from Amaryllidaceae, lycorine shows various biological effects on tumor cells. The survival rate of HL‐60 cells exposed to was decreased in dose‐dependent manner with 1 μM as the 50% inhibitory concentration (IC50), cell growth slowed down by arresting cycle at G2/M phase, and regeneration potential inhibited. exhibited typical apoptotic morphological changes, DNA “ladder” pattern, sub‐G1 peak phase distribution, showing apoptosis To further...