A5058621977- Growth Hormone and Insulin-like Growth Factors
- Neonatal and fetal brain pathology
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- Cancer, Hypoxia, and Metabolism
- Phytochemicals and Antioxidant Activities
- Neonatal Respiratory Health Research
- Stress Responses and Cortisol
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Neurological Disease Mechanisms and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Tryptophan and brain disorders
- Chromatography in Natural Products
- Mitochondrial Function and Pathology
- Protease and Inhibitor Mechanisms
- High Altitude and Hypoxia
- Regulation of Appetite and Obesity
- Drug Transport and Resistance Mechanisms
- Banana Cultivation and Research
- Lipid metabolism and disorders
- Bioactive Compounds and Antitumor Agents
Plant & Food Research
2008-2018
University of Auckland
1995-2017
Northumbria University
2014
AgResearch
2008
Maastricht University
2002-2007
European Graduate School
2007
European Graduate School of Neuroscience
2002-2007
The aim of this study was to determine the effects a clinically relevant single course prenatal betamethasone in rat on growth parameters with particular reference brain cell proliferation and apoptosis. We report that administration 170 microg kg-1 twice within 4 h E20 pregnant rats conveys moderate somatic retardation. Further, using measure independent blood-brain barrier (BBB) permeability, we demonstrate for first time is chronically anti-proliferative cells without inducing...
Scope Hops ( Humulus lupulus L.) produce unique prenylflavonoids that exhibit interesting bioactivities. This study investigates the interactions between selected and breast cancer resistance protein BCRP / ABCG 2), an efflux transporter important for xenobiotic bioavailability multidrug MDR ). Methods results 2‐inhibitory activity of xanthohumol XN ), isoxanthohumol IX 6‐prenylnaringenin (6‐ PN 8‐prenylnaringenin (8‐ 6,8‐diprenylnarigenin (6,8‐diPN) was evaluated using mitoxantrone...
The increasing prevalence and social burden of subclinical anxiety in the western world represents a significant psychosocial financial cost. Consumers are favouring more natural nonpharmacological approach for alleviating effects everyday stress anxiety. gamma-aminobutyric acid (GABA) receptor is primary mediator central inhibitory neurotransmission, GABA-receptor agonists well known to convey anxiolytic effects. Using an vitro screening identify naturally occurring phytochemical GABA...
Scope Blueberry consumption is believed to confer a cardiovascular health advantage, but the active compounds and effects require characterization. This study aims identify polyphenol metabolites in plasma after blueberry juice intake determine their bioactivity on endothelial cells. Methods results Three healthy individuals are recruited obtain profiles of bioavailable following juice. Of 33 phenolic screened, 12 aglycone acids detected maximum concentrations circulation time determined....
Prenatal stress has been shown to disturb neonatal rat brain development. The astroglial-specific neurotrophic factor S100B is known play an important role in normal In the present study, we investigated effects of prenatal on concentrations hippocampus 1-day-old Fischer 344 rats. Overall, resulted a 25% reduction hippocampal content. Further, male content was negatively correlated with plasma corticosterone levels. Positive correlations were found between female levels and fetal growth,...