A5101913479- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Clostridium difficile and Clostridium perfringens research
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Hemophilia Treatment and Research
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Cancer, Hypoxia, and Metabolism
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- Toxin Mechanisms and Immunotoxins
- Bone health and treatments
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Glutathione Transferases and Polymorphisms
- Mesenchymal stem cell research
- Circular RNAs in diseases
Lanzhou University
2015-2025
First Hospital of Lanzhou University
2015-2025
Shanghai University of Medicine and Health Sciences
2025
University of Science and Technology Beijing
2023-2024
Weatherford College
2021
Sichuan University
2005-2009
West China Hospital of Sichuan University
2005-2009
Abstract Introduction The prognosis of relapsed or refractory mature T‐ and natural killer (NK)‐cell lymphoma remains dismal. Novel agents are urgently needed to improve the outcomes for this population. Methods In phase 2, multicenter, open‐label, single‐arm study (NCT03776279), authors report efficacy safety liposomal mitoxantrone (Lipo‐MIT) monotherapy in patients with NK‐cell lymphoma. Lipo‐MIT was administered intravenously at 20 mg/m 2 once every 4 weeks. primary end points were...
Abstract Background Peripheral T cell lymphoma (PTCL) is a rare disease and recent approved drugs for relapsed/refractory (r/r) PTCL provided limited clinical benefit. We conducted this study to evaluate the efficacy safety of geptanolimab (GB226), an anti-PD-1 antibody, in r/r patients. Methods did single-arm, multicenter phase 2 across 41 sites China. Eligible patients with received 3 mg/kg intravenously every weeks until progression or intolerable toxicity. All who at least one dose...
Up to 30% of acute myeloid leukemia (AML) patients face unfavorable outcomes due the FMS-like receptor tyrosine kinase-3 (FLT3) internal tandem duplication (ITD) mutation. Although FLT3 inhibitors show encouraging in treatment, they fail eliminate stem cells, origin persistent and resistant lesions. Exploration mechanism FLT3-ITD+ AML maintenance chemoresistance is crucial for development novel therapeutic approaches. The manifestation pluripotency transcription factors (TFs) their link...
Salidroside is a natural product of phenols with wide range pharmacological functions, but whether it plays role in regulating autophagy unclear. We systematically investigated the regulatory effect and molecular mechanism salidroside on through network pharmacology, which provided theoretical basis for subsequent experimental research. First, target genes were obtained using Chinese Medicine System Pharmacology Database Analysis Platform, converted into standardized gene names Uniprot...
The aim of this study was to investigate the synergic antitumor effects arsenic trioxide (As2O3) and 3′-azido-3′-deoxythymidine (AZT) on hepatoma cells explore possible molecular basis these effects. These results showed that AZT enhanced inhibitory effect As2O3 HepG2 SMMC-7721 cell growth. IC50 in combination with lower than alone. A concentration-dependent (CI <1) observed all tested combinations compounds. also dramatically significantly increased number apoptotic cells. Studies vivo...
Agaricus blazei Murill is a native Brazilian mushroom which functions primarily as an anticancer substance in transplanted mouse tumors. However, the mechanism underlying this function of A. remains obscure. The present study was carried out to investigate effect fraction FA-2-b-ss, RNA-protein complex isolated from Murill, on human leukemia HL-60 cells vitro. Typical apoptotic characteristics were determined by morphological methods using DNA agarose gel electrophoresis and flow cytometry....
Ubiquitin-specific peptidase 39 (USP39) is one member of the cysteine proteases USP family, which represents largest group DeUbiquitinases with more than 50 members in humans. The roles USP39 human cancer have been widely investigated. However, leukemia and underlying mechanism remain unknown. Here we reported function leukemia. We observed that expression was up-regulated cells high correlated poor survival patients Lentivirus-mediated knockdown repressed proliferation colony formation cell...
The aim of this study was to evaluate the ability red blood cell distribution width (RDW) predict prognosis and treatment response in chronic myeloid leukemia (CML)-chronic phase (CP) patients treated with tyrosine kinase inhibitor (TKIs).We retrospectively enrolled 93 newly diagnosed CML-CP TKIs from 2009 2018 at First Hospital Lanzhou University. Patients were divided into 2 groups using an RDW 18.65% determined by receiver operating characteristic curve analysis. We analyzed correlation...
Acute myeloid leukemia (AML) is one of the most common hematologic malignancies with a poor prognosis and high recurrence rate. The discovery new predictive models therapeutic agents plays crucial role.The differentially expressed gene that was explicitly highly in Cancer Genome Atlas (TCGA) GSE9476 transcriptome databases were screened included least absolute shrinkage selection operator (LASSO) regression model to derive risk coefficients build score model. Functional enrichment analysis...
Objection Immunotherapy based on T cells is a new therapy for Acute myeloid leukemia (AML). However, there has not been considerable improvement compared with traditional chemotherapeutics. This study aimed to identify important immune cells, genes, and drugs associated the immunotherapy of AML.Methods The gene expression profile clinical data patients AML were downloaded from TCGA database, abundance ratio was obtained via CIBERSORT. Kaplan–Meier (KM) survival analysis used assess...
This study compared the efficacy, safety and immunogenicity of ripertamab (SCT400) rituximab (Mabthera® ) combined with CHOP as first-line treatment for Chinese patients CD20-positive diffuse large B cell lymphoma (DLBCL). is a randomized, patient-blind, multicenter, active-control, non-inferiority parallel design. Patients were randomly (2:1) to receive (S-CHOP) or (R-CHOP) up 6 cycles. The primary endpoint was Independent Review Committee (IRC) assessed objective response rate (ORR) in...
As one of the most popular sports, football has been a subject to growth and advancements in technology. The combination artificial intelligence is expected be used for intelligent analysis. Image semantic segmentation an important basis image analysis understanding. This paper proposes deep learning-based model pixel-level classification video recordings frames matches. Every pixel frame classified into 10 classes, e.g., players, ball, goal bar several background scenes. In this paper, we...
Infant acute lymphoblastic leukemia (ALL) with the mixed lineage ( MLL ) gene rearrangement -R) is considered a distinct from childhood or non- -R infant ALL. To detect key genes and elucidate molecular mechanisms of ALL, microarray expression data were downloaded Gene Expression Omnibus (GEO) database, differentially expressed (DEGs) between ALL identified. ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses carried out. Then, we constructed protein-protein...