A5045752884- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- Biosimilars and Bioanalytical Methods
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- CNS Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Sarcoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Nuclear Receptors and Signaling
- T-cell and Retrovirus Studies
- Chronic Myeloid Leukemia Treatments
- Circular RNAs in diseases
- Macrophage Migration Inhibitory Factor
- Ubiquitin and proteasome pathways
- HER2/EGFR in Cancer Research
- Cutaneous lymphoproliferative disorders research
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2015-2025
Shanghai Institute of Hematology
2014-2024
State Key Laboratory of Medical Genomics
2020-2024
Wenzhou Medical University
2024
Anhui Provincial Hospital
2024
Henan University
2020-2022
Fudan University
2022
Chifeng University
2021
China-Japan Friendship Hospital
2021
B-cell acute lymphoblastic leukemia is the most common type of pediatric leukemia. Despite improved remission rates, current treatment regimens for are often associated with adverse effects and central nervous system relapse, necessitating more effective safer agents. Bafilomycin A1 an inhibitor vacuolar H+-ATPase that frequently used at high concentration to block late-phase autophagy. Here, we show bafilomycin a low (1 nM) effectively specifically inhibited killed cells. It targeted both...
MicroRNAs (miRs) are involved in lymphoma progression by regulating tumor cell interaction with microenvironment. MiR155 is overexpressed diffuse large B-cell (DLBCL) and its biological effect on microenvironment needs to be futher investigated.MiR155 was detected quantitative real-time PCR patients newly diagnosed DLBCL. The mechanism of action miR155 examined vitro B-lymphoma lines vivo a murine xenograft model.Serum significantly elevated, correlated expression, indicated poor disease...
Abstract Purpose: NOTCH signaling pathway is essential in T-cell development and NOTCH1 mutations are frequently present acute lymphoblastic leukemia (T-ALL). To gain insight into its clinical significance, mutation was investigated 77 patients with T-ALL. Experimental Design: Detection of done using reverse transcription-PCR amplification direct sequencing, thereby compared according to the clinical/biological data patients. Results: Thirty-two were identified 29 (with dual 3 cases),...
Rationale: Epstein-Barr virus (EBV) is associated with multiple malignancies expression of viral oncogenic proteins and chronic inflammation as major mechanisms contributing to tumor development.A less well-studied mechanism the integration EBV into human genome possibly at sites which may disrupt gene or stability.Methods: We sequenced DNA profile sequences by hybridization-based enrichment.Bioinformatic analysis was used detect breakpoints integrations in cancer cells.Results: identified...
This study aimed to investigate the association of pre-treatment inflammatory status with survival time and develop a prognostic nomogram incorporating cytokines in non-Hodgkin's lymphoma.
Abstract Background Elderly patients with diffuse large B-cell lymphoma (DLBCL) present poor clinical outcome and intolerance to intensive chemotherapy. Histone deacetylase inhibitors (HDACIs) show anti-lymphoma activities can be applied treat DLBCL. This study aimed evaluate efficacy safety of oral HDACI tucidinostat (formerly known as chidamide) plus R-CHOP (CR-CHOP) in elderly newly diagnosed DLBCL (International Prognostic Index ≥ 2). Results Among 49 patients, the complete response rate...
To present 6 new cases with Homer-3 antibodies that expand their clinical spectra and to evaluate the effect of immunotherapy.Patients suspected autoimmune cerebellar disorder were tested for rare ataxia (ACA) (anti-Tr(DNER)/Zic4/ITPR1/Homer-3/NCDN/PKCγ/PCA-2/AP3B2/mGluR1/ATP1A3 antibodies) using both cell-based tissue-based assays. Patients positive serum or CSF results who diagnosed ACA registered followed up. This study reports analyzes antibodies.Of samples 750 patients tested,...
Abstract MicroRNAs (miRNAs) are involved in lymphoma progression by regulating the tumor microenvironment. Serum miR130b is overexpressed diffuse large B-cell (DLBCL), inducing Th17 cell alterations. To further illustrate its biological significance and therapeutic rationale, was detected quantitative real-time PCR serum samples of 532 newly diagnosed DLBCL patients. The mechanism on microenvironment investigated both vitro vivo. Therapeutic targeting also evaluated, including OX40 agonistic...
Cardiac side effects of doxorubicin (Dox) have limited its clinical application. The aim this study was to explore new Dox-loaded dextran-based nano-carriers (NCs) in efficiently targeting tumor growth with less cardiac toxicity.Inspired by recent reports that polymeric NCs could function as sustained, controlled and targeted drug delivery systems, we developed which displayed a 2-fold release ratio Dox the mimic site condition (pH 5.0 10 mM glutathione, GSH) much systemic circulation...
Epstein-Barr virus (EBV) represents an important pathogenic factor of lymphoma and is significantly associated with poor clinical outcome diffuse large B-cell (DLBCL). Circular RNAs (circRNAs) play essential role in progression. However, the underlying mechanism circRNA on DLBCL progression related to EBV remains largely unknown.CircRNA was screened by high-throughput sequencing tumor samples 12 patients according infection status. Expression circEAF2, as well relationship characteristics...
Common genetic variations in genes involved DNA repair or response to genotoxic stress may influence both cancer susceptibility and treatment individually interactively. However, acute myeloid leukemia (AML), the relevance of these remains be fully established. In this study, we analyzed 42 among 15 candidate 307 AML patients 560 age-sex matched controls. Their associations with chemotherapy were further evaluated combination other well-established prognostic factors. An increased risk was...
The difference between clinical characteristics and outcomes follicular lymphoma grade 1-2 (FL1-2) FL3a defined pathologically remains unclear, resulting in uncertainty how to treat FL3a. However, it may be crucial for clinicians discriminate 3a predicting prognosis thus making treatment decisions.
Recent reports indicated that high levels of interleukin 10 (IL-10) contribute to the monocytes paralysis and poor clinical outcome in acute liver failure (ALF). Polymorphisms promoter region IL-10 affect production confer susceptibility inflammatory diseases. The aim this study was determine possible association three polymorphisms (A-1082G, T-819C, A-592C) gene with hepatitis B virus (HBV)-related ALF a Chinese population. were genotyped 414 unrelated healthy blood donors, 367 asymptomatic...
T-bet is a key regulator for the lineage commitment in CD4 T helper (Th) 1 cells by activating hallmark production of interferon-γ, and its expression level linked to autoimmune, infectious, allergic diseases. A C base substitution has been identified at position -1993 TBX21 (encoding T-bet) promoter associated with asthma systemic lupus erythematosus. This study aimed investigate molecular mechanisms responsible influence T-1993C polymorphism on transcription functional effect luciferase...