A5100786761- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Antibiotic Resistance in Bacteria
- Lung Cancer Research Studies
- Hematological disorders and diagnostics
- Histone Deacetylase Inhibitors Research
- Neutropenia and Cancer Infections
- T-cell and B-cell Immunology
- Neonatal Respiratory Health Research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Hydrology and Watershed Management Studies
- Muscle Physiology and Disorders
Army Medical University
2014-2025
General Hospital of Shenyang Military Region
2025
Chinese People's Liberation Army
2025
China University of Petroleum, East China
2019-2025
Xinqiao Hospital
2012-2024
Shanghai East Hospital
2024
Renji Hospital
2024
Shanghai Jiao Tong University
2024
Chongqing Medical University
2020-2023
Second Affiliated Hospital of Chongqing Medical University
2020-2023
Relapse is a major cause of treatment failure after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) for high-risk acute myeloid leukemia (HR-AML). The aim this study was to explore the effect recombinant human granulocyte colony-stimulating factor (rhG-CSF) combined with minimal-dose decitabine (Dec) on prevention HR-AML relapse allo-HSCT.We conducted phase II, open-label, multicenter, randomized controlled trial. Two hundred four patients who had received allo-HSCT 60-100...
Clinical trials have confirmed that chimeric antigen receptor (CAR) T cell therapies are revolutionizing approaches for treating several relapsed or refractory hematological tumors. Cytokine release syndrome (CRS) is an adverse event with high incidence during CAR-T treatment. A further understanding of the characteristics and related risk factors CRS important effective management. total 142 patients acute lymphocyte leukemia (ALL), lymphoma, multiple myeloma (MM) received lymphodepletion...
Abstract Safety and efficacy of allogeneic anti-CD19 chimeric antigen receptor T cells (CAR-T cells) in persons with CD19-positive B-cell acute lymphoblastic leukemia (B-ALL) relapsing after an allotransplant remain unclear. Forty-three subjects B-ALL post received CAR-T were analyzed. 34 (79%; 95% confidence interval [CI]: 66, 92%) achieved complete histological remission (CR). Cytokine release syndrome (CRS) occurred 38 (88%; 78, 98%) was ≥grade-3 7. Two died from multiorgan failure CRS....
Chronic graft-vs-host disease (GVHD) limits the long-term benefit of haploidentical hematopoietic stem cell transplant (HSCT). This clinical trial evaluated repeated infusions umbilical cord mesenchymal cells (MSCs) during early stage (45 days and 100 days) after haplo-HSCT to prevent chronic GVHD.
Aim Circulating tumor cells (CTC) are a precursor to metastasis in several types of cancer and occasionally found the bloodstream association with immune cells, such as white blood (WBCs). CTC-associated WBC (CTC-WBC) clusters can promote CTC appreciation metastasis, suggesting that patients CTC-WBC peripheral may have worse prognosis. However, it is unclear whether present hepatocellular carcinoma (HCC) suggest poor prognosis for HCC. Methods We collected from 214 HCC January 2014 December...
Burrs generated during the drilling of carbon fiber-reinforced plastics (CFRPs) would seriously reduce service life components, potentially leading to assembly errors and part rejection. To solve this issue, paper proposed a finite element (FE) model with multiscale modeling investigate formation distribution burrs at various processing conditions. The FE comprised microscopic fiber resin phases predict process burrs, while CFRP layers was defined be macroscopic equivalent homogeneous...
Phospholipase A2 (PLA2) enzymes are pivotal in various biological processes, such as lipid mediator production, membrane remodeling, bioenergetics, and maintaining the body surface barrier. Notably, these play a significant role development of diverse tumors.
The aim of this study was to investigate the feasibility and safety retrograde puncture for trocar placement establishment preperitoneal space in laparoscopic total extraperitoneal repair (TEP) groin hernias. A retrospective analysis clinical data 1388 patients who underwent TEP surgery a hernia at General Hospital Northern Theater Command Chinese People's Liberation Army (hereinafter referred as Command) from August 2013 2023 conducted. were examined. All operations successful, with no...
Abstract Introduction: Patients with T cell malignancies usually have high relapse and mortality rates. Due to shared common surface antigen potential contamination by malignant cells, development of CAR-T therapies for r/r T-ALL has been lagged, regardless the costly lengthy process autologous production. To overcome these challenges, we developed a universal platform (TruUCAR™) that displayed superior expansion in patients without using preconditioning biologics such as αCD52 antibody....
Minimal residual disease (MRD) is an important prognostic factor for survival in adults with acute leukemia. The role of pretransplantation MRD status myelodysplastic syndrome excess blasts (MDS-EB) unknown. This study retrospectively analyzed the relationship between and long-term survival.Patients MDS-EB who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from March 5, 2005, to November 8, 2020, were included. was using univariate multivariate logistic regression...
Neoadjuvant nivolumab plus chemotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) versus alone in patients with resectable non-small-cell lung cancer (NSCLC) the global phase III CheckMate 816 study. Here, we report post hoc exploratory efficacy, safety, surgical outcomes Chinese subpopulation of this
Dysregulation of cytokines and growth factors is a general feature tumor microenvironment, unraveling the expression spectrum cytokine factor in niche utmost importance. Here, we evaluated profiling bone marrow serum samples AML patients healthy controls. Protein from nine five controls was obtained using biotinylated antibody chip. A total 507 were analyzed. Compared with people, expressed 31 signature proteins, among which, 27 significantly higher 4 proteins lower. When divided into...
Antimicrobial resistance (AMR) is one of the most significant threats to global public health. As antibiotic failure increasing, phages are gradually becoming important agents in post-antibiotic era. In this study, therapeutic effects and safety kpssk3, a previously isolated phage infecting carbapenem-resistant hypermucoviscous Klebsiella pneumoniae (CR-HMKP), were evaluated mouse model systemic CR-HMKP infection. The efficacy experiment showed that intraperitoneal injection with single dose...
Abstract Liver metastasis (LM) is an important factor leading to colorectal cancer (CRC) mortality. However, the effect of T‐cell exhaustion on LM in CRC unclear. Single‐cell sequencing data derived from Gene Expression Omnibus database. Data were normalized using Seurat package and subsequently clustered annotated into different cell clusters. The differentiation trajectories epithelial cells T characterized based pseudo‐time analysis. Single‐sample gene set enrichment analysis (ssGSEA) was...
// Shijie Yang 1, 2, * , Qin Wen Yao Liu 2 Cheng Zhang Maihong Wang Guo Chen Yi Gong Jiangjian Zhong 3 Xuelian 1 Andres Stucky Jiang F. Xi Ostrow School of Dentistry and Department Pediatrics, Medicine, University Southern California, Los Angeles, CA, USA Hematology Blood Transfusion, Xinqiao Hospital, Third Military Medical University, Chongqing, P. R. China Z-Genetic Medicine LLC, Temple City, These authors have contributed equally to this work Correspondence to: Zhong, e-mail:...
Refractory and relapsed acute myeloid leukemia (r/rAML) is associated with a difficult prognosis; clinical trials are typically suggested despite lack of recognized standard care. Combinatorial chemotherapy regimens utilized for r/rAML salvage play crucial role in battling this invasive phase. Although it characterized by low response rate, CLAG traditional regimen used r/rAML. We aimed to compare the efficacy toxicity CLAG+PLD explore whether there was any improvement addition pegylated...
•Penpulimab combined with anlotinib demonstrated promising efficacy in R/M HNSCC patients.•Manageable safety was observed patients treated penpulimab anlotinib.•These results support further study of HNSCC. BackgroundTreatment regimens for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) after failure platinum-based chemotherapy have been illustrated limited efficacy.Patients methodsHere, we report a single-arm, multicenter, phase Ⅱ programmed death-1 antibody (200...