A5101955981- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Cancer Genomics and Diagnostics
- Chemokine receptors and signaling
- Drug Transport and Resistance Mechanisms
- Organ Donation and Transplantation
- Mesenchymal stem cell research
- Facial Rejuvenation and Surgery Techniques
- Pancreatic and Hepatic Oncology Research
- Dermatologic Treatments and Research
- Reconstructive Surgery and Microvascular Techniques
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Reconstructive Facial Surgery Techniques
- Intraperitoneal and Appendiceal Malignancies
- Cardiac Health and Mental Health
Southern Medical University
2016-2025
Zhujiang Hospital
2016-2025
Nanjing Medical University
2024
Jiujiang Maternal and Child Care Centres
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2021
Peking Union Medical College Hospital
2019-2021
Nanfang Hospital
2021
Plastic Surgery Hospital
2018-2019
Stanford University
2016
Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), and reducing sorafenib resistance an important issue to be resolved the clinical treatment of HCC. In current study, we identified that ABCC5 critical regulator promising therapeutic target acquired in human cells. The expression was dramatically induced sorafenib-resistant HCC cells remarkably associated with poor prognoses. down-regulation could significantly reduce Importantly, activation...
Laparoscopic caudate lobectomy (LCL) is one of the most challenging types laparoscopic liver resections. The main difficulty lies in deep anatomical position lobe, which closely adjacent to first and second hepatic ports inferior vena cava, increasing risk major bleeding during surgery. In addition a thorough understanding anatomy lobe tumor, comprehensive imaging assessment, three-dimensional reconstruction, flexible choice surgical approach also key reducing improving safety. We perform...
Infections, cancer, and trauma can cause life-threatening hyperinflammation. In the present study, using single-cell RNA sequencing of circulating immune cells, we found that mammalian target rapamycin (mTOR) pathway plays a critical role in myeloid cell regulation COVID-19 patients. Previously, developed an mTOR-inhibiting nanobiologic (mTORi-nanobiologic) efficiently targets cells their progenitors bone marrow. vitro, demonstrated mTORi-nanobiologics potently inhibit infection-associated...
Aim Circulating tumor cells (CTC) are a precursor to metastasis in several types of cancer and occasionally found the bloodstream association with immune cells, such as white blood (WBCs). CTC-associated WBC (CTC-WBC) clusters can promote CTC appreciation metastasis, suggesting that patients CTC-WBC peripheral may have worse prognosis. However, it is unclear whether present hepatocellular carcinoma (HCC) suggest poor prognosis for HCC. Methods We collected from 214 HCC January 2014 December...
Abstract Background Circulating tumour cells (CTCs), especially mesenchymal CTCs, are important determinants of metastasis, which leads to most recurrence and mortality in hepatocellular carcinoma (HCC). However, little is known about the underlying mechanisms CTC colonisation pre-metastatic niches. Methods Detection classification CTCs patients were performed using CanPatrol™ system. A lentiviral vector expressing Prrx1-targeting shRNA was constructed generate a stable HCC cell line with...
The abnormal expression of long noncoding RNAs (lncRNAs) is associated with human carcinoma. present study aimed to investigate the mechanisms underlying function lncRNA AK002107 in progression hepatocellular carcinoma (HCC). differential lncRNAs between HCC and paired nontumor tissues was identified using microarrays, correlation clinical prognosis analyzed. We investigated role tumor biology vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT), colony formation,...
Acute liver failure (ALF) causes severe injury and a systemic inflammatory response, leading to multiorgan with high short-term mortality. Bioartificial (BAL) therapy is promising approach that hampered by the lack of appropriate bioreactors carriers retain hepatic cell function poor understanding BAL treatment mechanisms in ALF extrahepatic organ injury. Recently, we used fiber scaffold bioreactor (FSB) for high-density, three-dimensional (3D) culture primary porcine hepatocytes (PPHs)...
Abstract Background and Aim Bioartificial livers (BALs) are considered as a solution to bridge patients with acute liver failure transplantation or assist in spontaneous recovery for end‐stage disease. Pig is the best donor of hepatocytes BALs clinical trials, because metabolic detoxification function its close human. However, using pig remains controversial safety concern owing nonhuman proteins secretion. Herein, we attempt establish modified pigs expressing humanized proteins,...
Hepatocellular carcinoma (HCC) is an aggressive form of cancer characterized by a high recurrence rate following resection. Studies have implicated stromal and immune cells, which part the tumor microenvironment, as significant contributors to poor prognoses HCC patients. In present study, we first downloaded gene expression datasets for patients from The Cancer Genome Atlas database categorized into low or score groups. By comparing those groups, identified differentially expressed genes...
Type I collagen is the most abundant protein in human body. Fibrosis characterized by excessive synthesis of type parenchymal organs. It a leading cause morbidity and mortality worldwide, about 45% all natural deaths are attributable to some fibroproliferative disease. There no cure for fibrosis. To find specific antifibrotic therapy targeting collagen, critical molecular interactions regulating its must be elucidated. III mRNAs have unique sequence element at 5' end, stem-loop. This...
To establish a reversible porcine model of acute liver failure (ALF) and treat it with an artificial system.Sixteen pigs weighing 30-35 kg were chosen administered acetaminophen (APAP) to induce ALF. ALF then randomly assigned either experimental group (n = 11), in which treatment procedure was performed, or control 5). Treatment started 20 h after APAP administration continued for 8 h. Clinical manifestations all animals, including kidney functions, serum biochemical parameters survival...
To establish a simplified, reproducible D-galactosamine-induced cynomolgus monkey model of acute liver failure having an appropriate treatment window.Sixteen monkeys were randomly divided into four groups (A, B, C and D) after intracranial pressure (ICP) sensor implantation. D-galactosamine at 0.3, 0.25, 0.20 + 0.05 (24 h interval), g/kg body weight, respectively, was injected via the small saphenous vein. Vital signs, ICP, biochemical indices, inflammatory factors recorded 0, 12, 24, 36,...
Acute liver failure (ALF) is a severe disease with high morbidity and mortality rates. Animal models are important for research on ALF. This study aimed to establish reproducible, Tibetan miniature pig model of D-galactosamine-induced ALF verify it using dual plasma molecular adsorption system (DPMAS).Tibet pigs were randomly divided into four groups (A, B, C, D) after catheterization. D-galactosamine (D-gal) at 0.45, 0.40, 0.35, 0.35 g/kg body weight, respectively, was injected through the...
Background/Aims: The use of antibiotics to eliminate Mycoplasma contamination has some serious limitations. can be eliminated by intraperitoneal injection BALB/c mice with contaminated cells combined screening monoclonal cells. However, in vivo passage after requires a long duration (20-54 days). Furthermore, it is important monitor for cross-contamination mouse and human cells, xenotropic murine leukemia virus-related virus (XMRV) infection, altered cell function the treatment. present...
Models using large animals that are suitable for studying artificial liver support system (ALSS) urgently needed. Presently available acute failure (ALF) models mainly involve pigs or dogs. Establishment of current surgical ALF (hepatectomy/devascularization) requires either very good skills multistep processes—even multiple stages surgery. Therefore, it is necessary to develop a simplified method. Here we report novel model cynomolgus monkeys. Six monkeys underwent portal-right renal venous...
Renal dysfunction is one of the most common complications liver cirrhosis and associated with increased morbidity mortality. However, no available technology can simultaneously support renal function in these patients. The aim this study was to evaluate safety efficacy an artificial system cynomolgus monkeys surgery-induced ARF. ARF model established by ligature bilateral arteries eight monkeys, which were randomly divided into a treatment group (<mml:math...
Hepatocellular carcinoma (HCC) is the sixth most commonly diagnosed malignancy and third leading cause of cancer-related deaths worldwide. A 58-year-old man visited his local hospital due to abdominal discomfort was with lung metastasis. After admission our in April 2020, he received two cycles transcatheter arterial embolization (TAE), hepatic infusion chemotherapy (HAIC-Folfox), sorafenib, camrelizumab every 3 weeks. Due end HAIC treatment, underwent drug-eluting chemoembolization (dTACE)...
Abstract Background Hepatocellular carcinoma with spontaneous rupture (rHCC) is managed through conservative treatment, emergency resection, and trans-arterial embolisation. However, peritoneal implantation metastasis (PIM) remains highly likely owing to intraperitoneal free cancer cell dispersion within the abdominal cavity before achieving haemostasis. Although resection combined hyperthermic intra-peritoneal chemotherapy (R-HIPEC) used in its effectiveness preventing PIM of rHCC...
Background.Epistaxis is frequently observed in allergic rhinitis (AR) patients.However, few studies focus on the outcome of epistaxis with treatment AR patients.This study aimed to retrospectively analyze efficacy and safety patients treated sublingual immunotherapy (SLIT).Methods.A total 74 aged 4-60 years house dust mite (HDM)-induced accompanied by who completed 1 year SLIT standard Dermatophagoides farinae (D. farinae) drops were enrolled this study.The symptom scores, medication scores...
To investigate the clinical characteristics and correlated factors of preoperative sleep disorders in patients undergoing various types cardiac surgery.
Abstract Despite the advancements in treatment strategies, long-term survival of hepatocellular carcinoma (HCC) is still pessimistic. Therefore, understanding mechanisms may offer substantial benefits for patients. Our previous research has revealed that Hornerin promoted HCC progression by regulating AKT signaling pathway. To investigate upstream regulatory mechanism, results from RNA Immunoprecipitation and pull-down indicated specific region circIPP2A2 interacted with Hornerin....
The tumor suppressor wild-type p53 is known for its role in inducing apoptosis cells. This study investigated the relationship between and protein phosphatase 1 (PP1) caspase promoting of breast cancer
<title>Abstract</title> Patients with unresectable hepatocellular carcinoma (uHCC) have poor long-term prognosis, necessitating alternative treatment modalities. We assessed the efficacy and safety of tyrosine kinase inhibitors immune checkpoint combined either transarterial chemoembolisation, hepatic artery infusion chemotherapy, or transcatheter arterial embolisation chemotherapy in patients uHCC. The efficacy, represented by survival tumour response, tolerability, adverse event frequency...