A5101508623- Bladder and Urothelial Cancer Treatments
- Medical Imaging Techniques and Applications
- Cancer, Lipids, and Metabolism
- Surgical Simulation and Training
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- MicroRNA in disease regulation
- Cervical Cancer and HPV Research
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Cells and Metastasis
- Urinary and Genital Oncology Studies
- Cancer survivorship and care
- Lung Cancer Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Renal and Vascular Pathologies
- Glioma Diagnosis and Treatment
- Augmented Reality Applications
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Clusterin in disease pathology
Qingdao University
2013-2024
Affiliated Hospital of Qingdao University
2015-2024
Hubei Provincial Hospital of Traditional Chinese Medicine
2024
Neijiang Normal University
2023
Kunming Medical University
2021-2023
Hubei University of Medicine
2021
Nanjing University of Chinese Medicine
2021
Fujian Medical University
2020
Weatherford College
2020
Guangxi University of Chinese Medicine
2020
Although pretreatment neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte (LMR), and platelet–lymphocyte (PLR) are reportedly associated with clinical outcomes of many cancers, their roles in patients bladder cancer (BCa) who undergo radical cystectomy (RC) have not been widely investigated. We analyzed relationships between preoperative NLR, LMR, PLR, overall survival (OS) 124 BCa undergoing RC. OS curves were drawn using the Kaplan–Meier method evaluated log-rank test. Relationships...
Gastric cancer (GC) is the fifth most common malignancy and third leading cause of cancer‑associated mortality in world. However, its mechanisms occurrence development have not been clearly elucidated. Furthermore, there no effective tumor marker for GC. Using DNA microarray analysis, present study revealed genetic alterations, screened out core genes as novel markers discovered pathways potential therapeutic targets. Differentially expressed (DEGs) between GC adjacent normal tissues were...
To explore the effect of Circular RNA Itchy E3 ubiquitin protein ligase (Circ-ITCH) on regulating epithelial ovarian cancer (EOC) cells proliferation and apoptosis, as well its potential target microRNAs (miR) in vitro.Circ-ITCH mimic, blank Circ-ITCH inhibitor plasmids were transfected into SKOV3 cells. Rescue experiments carried out by transfecting miR-10a mimic mimic/Circ-ITCH Quantitative polymerase chain reaction (qPCR) was performed to detect expression. Cells determined Cell Counting...
Penile squamous cell carcinoma (PSCC) is a malignancy that affects the skin and tissues of penis, but knowledge pathogenesis carcinogenesis limited. Here, we characterize PSCC genomic landscape using whole-exome sequencing. Of 30 paired blood tumor samples, identified recurrent mutations in 11 genes; confirmed previous findings for FAT1 (4/30), HRAS NOTCH1 TP53 (3/30) PIK3CA (3/30); revealed novel candidate driver genes [CASP8 SLITRK2 (3/30), FLG TRRAP (3/30)]. Our vitro experiments...
Abstract Background Circulating tumour cells (CTCs), especially mesenchymal CTCs, are important determinants of metastasis, which leads to most recurrence and mortality in hepatocellular carcinoma (HCC). However, little is known about the underlying mechanisms CTC colonisation pre-metastatic niches. Methods Detection classification CTCs patients were performed using CanPatrol™ system. A lentiviral vector expressing Prrx1-targeting shRNA was constructed generate a stable HCC cell line with...
The aim of this study was to test the effectiveness, safety and stability 5G communication technology in clinical laparoscopic telesurgery. An ultra-remote radical cystectomy (network distance nearly 3000 km) performed on patient diagnosed with T2N0M0 stage bladder cancer using a domestically produced "MicroHand" surgical robot. network delay, operative time, blood loss, intraoperative complications, postoperative recovery, hospitalisation time were recorded. used throughout operation, an...
The Advanced Lung Cancer Inflammation Index (ALI) represents both the inflammatory and nutritional status of host, but its link with mortality in asthma patients is uncertain. purpose this study was to look at relationship between ALI levels all-cause respiratory disease asthmatic patients. We conducted our research using cohort data from National Health Nutrition Examination Survey (NHANES) 1999 2018. Death used calculate until December 31, 2019. employed multivariate logistic regression...
Glutamate receptor, ionotropic, kainate 3 (GRIK3), as a member of the glutamate receptor family, mainly participated in neuroactive ligand interaction pathway. Other members GRIK family were previously reported to regulate cellular migration, transformation, and proliferation tumor. However, mechanism GRIK3 tumor is still unclear. Therefore, purpose our study was reveal expression clinical significance gastric cancer (GC). First, we performed analysis survival using The Cancer Genome Atlas...
The aim of this study was to investigate the prognostic value preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), and lymphocyte-monocyte (LMR) in patients with upper urinary tract urothelial carcinoma (UUTUC).We retrospectively analyzed clinical data 140 UUTUC who underwent radical nephroureterectomy from January 2005 December 2011. We plotted receiver operating characteristic curves NLR, PLR, LMR for diagnosis tumor recurrence. Survival analysis performed using...
MicroRNAs (miRNAs) are involved in cancer development and progression. Renal cell carcinoma (RCC) frequently undergoes metastasis has a high mortality rate. The current study measured miRNA‑126 (miR‑126) expression levels 128 pairs of clear RCC adjacent normal kidney tissue samples by reverse transcription‑quantitative polymerase chain reaction, analyzed the association between miR‑126 various clinicopathological parameters. In addition, proliferation, wound healing invasion assays were...
Recent studies have indicated that low circulating adiponectin concentrations are associated with a higher risk of several cancers, including renal cell carcinoma. In this case-control study, we examined the frequency single nucleotide polymorphisms (rs182052G>A, rs266729C>G, and rs3774262G>A) in gene (ADIPOQ) 1004 patients clear carcinoma (ccRCC) compared group healthy subjects (n = 1108). Fasting serum were also examined. Logistic regression models used to estimate odds ratios (OR) 95%...
Clusterin (CLU) is implicated in regulating clear renal cell carcinoma (CRCC) progression and metastasis, yet the mechanisms are not elucidated. In present study, we explored potential role of CLU CRCC metastasis.Levels mRNA protein were measured by RT-PCR immunohistochemistry analysis 22 with metastasis without samples normal kidney tissue. After silencing re-expression, migration invasion vitro vivo Caki-2 cells determined wound healing assay, transwell assay pulmonary nodule respectively....
T4N0-1 non-small-cell lung cancer (NSCLC) was historically considered curable but now includes tumours of size >7 cm according to the 8th edition tumour, node and metastasis (TNM) staging. This study set out evaluate role surgery predictors long-term survival after in this renewed group patients.Patients, with clinical T4N0-2M0 NSCLC diagnosed 2010-2013, National Cancer Database were queried. A Cox regression analysis applied investigate independent 1588 N0-1 surgical cases. For previous T3...
Evidence of the association metabolic syndrome (MetS) with cancer risk is accumulating. However, uncertainties still exist as to link MetS bladder cancer. This study aimed assess relationship between and urothelial carcinoma (UC) in a Chinese population.We retrospectively analyzed clinicopathological data 972 newly diagnosed UC patients 1098 cancer-free controls matched cases by age gender. Odds ratios (ORs) 95% confidence intervals (CIs) were calculated using unconditional logistic...
This article is a meta-analysis aiming to systematically assess the efficacy and safety profiles of PD-1/PD-L1 inhibitors in patients with advanced or metastatic bladder cancer.We extracted examined data from phase I, II, III clinical trials Medline, Embase, Cochrane Library, which included cancer who were treated inhibitors. We performed investigate several indexes safety, including objective response rate (ORR), 1-year overall survival (OS) rate, progression-free (PFS) adverse event (AE)...
The current study investigated the mechanism underlying sunitinib resistance. parental human renal cell carcinoma (RCC) line 786-O was continuously exposed to various doses of obtain sunitinib-resistant cells (786-O/S). Cell proliferation and colony formation assays were performed assess survival 786-O/S cells. half-inhibitory concentration for drug-resistant calculated. demonstrated notably morphological changes compared with Compared cells, exhibited stronger proliferative colony-forming...
Abstract The inflammatory process in systemic lupus erythematosus (SLE) affects many organs including the lungs. Chemokines are suggested to play important roles pathogenesis of SLE with pulmonary fibrosis (PF). In present study, our objective is evaluate correlation between chemokines and PF patients. Transcriptome sequencing analysis was used find different expressed genes patients without PF. Enzyme‐linked immunosorbent assay (ELISA) detect serum levels healthy controls. Expression CX3CR1...