A5071005996- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Myasthenia Gravis and Thymoma
- Medical Imaging and Pathology Studies
- Chemical Reactions and Isotopes
- Neuroendocrine Tumor Research Advances
- Cancer therapeutics and mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- RNA modifications and cancer
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Respiratory and Cough-Related Research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Occupational and environmental lung diseases
- Cancer, Lipids, and Metabolism
- Asthma and respiratory diseases
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Peptidase Inhibition and Analysis
- Vascular Tumors and Angiosarcomas
- Pituitary Gland Disorders and Treatments
- Advanced Neural Network Applications
Guangzhou University of Chinese Medicine
2018-2025
Hematology Oncology Consultants
2019-2025
Fuzhou University
2023-2025
Fujian Medical University
2025
Qingdao University
2017-2024
Affiliated Hospital of Qingdao University
2017-2024
Guangdong Academy of Medical Sciences
2016-2024
Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality
2024
Michigan Cancer Research Consortium
2023
Nantong Tumor Hospital
2021-2022
Whether pembrolizumab given both before surgery (neoadjuvant therapy) and after (adjuvant therapy), as compared with adjuvant therapy alone, would increase event-free survival among patients resectable stage III or IV melanoma is unknown.In a phase 2 trial, we randomly assigned clinically detectable, measurable IIIB to IVC that was amenable surgical resection three doses of neoadjuvant pembrolizumab, surgery, 15 (neoadjuvant-adjuvant group) followed by (200 mg intravenously every 3 weeks for...
Long non-coding RNAs (LncRNAs) have been recently found to be pervasively transcribed in the genome and critical regulators of epigenome. HOTAIR, as a well-known LncRNA, has play important roles several tumors. Herein, clinical application value biological functions HOTAIR were focused explored esophageal squamous cell carcinoma (ESCC). It was that there great upregulation ESCC compared their adjacent normal tissues. Meanwhile, patients with high expression significantly poorer prognosis...
Bladder cancer is one of the concerning malignancies worldwide, which lacking effective targeted therapy. Gene therapy a potential approach for bladder treatment. While, safe and gene delivery system urgently needed prompting treatment
Abstract Molecular subtypes of small cell lung cancer (SCLC) defined by the expression key transcription regulators have recently been proposed in lines and limited number primary tumors. The clinical biological implications neuroendocrine (NE) metastatic SCLC, extent to which they vary within between patient tumors patient-derived models is not known. We integrate histology, transcriptome, exome, treatment outcomes SCLC from a range sites, revealing complex intra- intertumoral heterogeneity...
Asbestos is the main cause of human malignant mesothelioma (MM). In vivo, macrophages phagocytize asbestos and, in response, release TNF-alpha and other cytokines that contribute to carcinogenesis through unknown mechanisms. vitro, does not induce transformation primary mesothelial cells (HM); instead, very cytotoxic HM, causing extensive cell death. This finding raised an apparent paradox: How can MM if HM exposed die? We found induced secretion expression receptor I HM. Treatment with...
NOTCH signaling is an evolutionarily conserved pathway that regulates cell fate during development and postnatal life. It has been increasingly linked to carcinogenesis, although its role in cancer seems be highly context tissue specific. Although required for lung development, little known about cancer. In this study, we show signaling, as measured by the gamma-secretase cleavage product N(IC)-1, active both normal human tumor samples; however, downstream readouts (i.e., HES-1 HES-5) are...
9000 Background: Immune checkpoint inhibition is now given in combination with chemotherapy for first line (1L) therapy of extensive stage small cell lung cancer (ES-SCLC). We conducted a randomized phase II study nivolumab (anti-PD1) platinum-etoposide (CE) as 1L treatment patients ES-SCLC (EA5161, NCT03382561). Methods: Patients measurable (RECIST v1.1) ES-SCLC, ECOG performance status 0 or 1, who had not received prior systemic were enrolled. 1:1 to 360 mg + CE every 21 days 4 cycles...
Although the median age at diagnosis of non-small cell lung cancer (NSCLC) is 70 years, a subset patients with NSCLC present younger (<40 years). Little known about time-trends in incidence young, their characteristics and outcomes.The surveillance, epidemiology, end results database was used to extract cases from 1978 2010. Yearly rates various groups, race, site disease, histology, treatment patterns, outcomes were assessed. We modeled Kaplan-Meyer survival curves stratified by...
Programmed death receptor-ligand 1 (PD-L1) plays a crucial role in immune evasion by tumour cells. Most cells exhibit energy dependency and acquire from glycolysis. However, the relationship between glucose metabolism PD-L1 expression remains unclear. In this study, changes renal carcinoma were evaluated during deficiency recovery, could inversely regulate addition, possible signalling pathways activated low level of to tested experimentally. The results showed that upregulate two cancer...
In the phase 3 study involving use of durvalumab with or without tremelimumab in combination platinum-based chemotherapy untreated extensive-stage SCLC (CASPIAN study), first-line plus platinum-etoposide (EP) significantly improved overall survival (OS) versus EP alone (p = 0.0047). We report exploratory subgroup analyses treatment patterns and outcomes according to presence baseline brain central nervous system metastases.Patients (WHO performance status 0 1), including those asymptomatic...
Cancer-associated fibroblasts (CAFs), the predominant stromal cell of tumor microenvironment (TME), play an important role in progression and immunoregulation by remodeling extracellular matrix (ECM) secreting cytokines. However, little is known about details underlying mechanism bladder cancer.Bioinformatics analysis was performed to analyze prognostic value CAFs CXCL12 using GEO, TCGA SRA databases. The effects on cancer were investigated through vitro vivo assays. biological effect PDL1...
Abstract Malignant mesothelioma (MM) is a cancer of the lining lungs, heart, and intestine known to respond poorly chemotherapy. Here we show that malignant mesothelial cells have an elevated Notch signaling pathway compared with normal human cells. We studied role in MM under normoxic hypoxic conditions, latter condition best recapitulating microenvironment. Genetic chemical modulation indicated are dependent on signaling. More specifically, this was Notch-1 as result its negative...
This phase I/II study sought to determine the safety and maximum tolerated dose (MTD) of a novel schedule belinostat, histone deacetylase inhibitor (HDAC) administered before in combination with cisplatin (P), doxorubicin (A), cyclophosphamide (C) thymic epithelial tumors (TET). Antitumor activity, pharmacokinetics, biomarkers response were also assessed.
// Anish Thomas 1 , Yuanbin Chen Seth M. Steinberg 2 Ji Luo 3 Svetlana Pack 4 Mark Raffeld Zied Abdullaev Christine Alewine 5 Arun Rajan Giuseppe Giaccone 6 Ira Pastan Markku Miettinen Raffit Hassan Thoracic and GI Oncology Branch, National Cancer Institute, Institutes of Health, Bethesda, MD, USA Biostatistics Data Management Section, Center for Research, Laboratory Biology Genetics, Pathology, Molecular Biology, Lombardi Center, Georgetown University, Washington DC, Correspondence to:...
Abstract The programmed death-ligand 1/programmed death-1 (PD-L1/PD-1) pathway plays a pivotal role in the immune escape of tumors. Many tumor cells show “glutamine dependence.” However, relationship between glutamine metabolism and PD-L1 expression has not been reported. In this study, changes renal carcinoma were evaluated during deprivation recovery. Although differed two cancer cell lines, both lines upregulated deprivation, was restored to normal after Mechanistically, resulted...
Limited-stage (LS) small-cell lung cancer (SCLC) remains an area of high unmet medical need. The standard-of-care therapy comprises curative-intent platinum-based chemotherapy with concurrent radiotherapy (cCRT), which can be followed by prophylactic brain irradiation and then observation. However, most patients will relapse. Durvalumab (antiprogrammed cell death ligand-1) has enhanced the efficacy outcomes after cCRT for unresectable, stage III non-small-cell cancer. Recently, durvalumab...