A5071509391- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
- Brain Tumor Detection and Classification
- Phytochemical compounds biological activities
- Advanced Neural Network Applications
- Neuroscience and Neuropharmacology Research
- Synthesis of Organic Compounds
- Medicinal Plants and Neuroprotection
- Plant biochemistry and biosynthesis
- Speech Recognition and Synthesis
- Image Retrieval and Classification Techniques
- AI in cancer detection
- Vascular Malformations Diagnosis and Treatment
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Phytochemicals and Antioxidant Activities
- COVID-19 diagnosis using AI
- Phenothiazines and Benzothiazines Synthesis and Activities
- Medical Image Segmentation Techniques
- Fungal Biology and Applications
- Pharmacological Receptor Mechanisms and Effects
- Free Radicals and Antioxidants
Fuzhou University
2023-2025
Fujian Medical University
2025
Liaoning Normal University
2006-2024
Tianjin University
2022
Beijing Normal University
2008
Yeungnam University
2000-2007
Medical image segmentation is a crucial and intricate process in medical processing analysis. With the advancements artificial intelligence, deep learning techniques have been widely used recent years for segmentation. One such technique U-Net framework based on U-shaped convolutional neural networks (CNN) its variants. However, these methods limitations simultaneously capturing both global remote semantic information due to restricted receptive domain caused by convolution operation's...
Familial cerebral cavernous malformation (FCCM) is a hereditary disorder characterized by abnormal vascular structures within the central nervous system. The FCCM lesions are often numerous and intricate, making quantitative analysis of labor-intensive task. Consequently, clinicians face challenges in quantitatively assessing severity determining whether have progressed. To alleviate this problem, we propose statistical framework for FCCM, which comprises an efficient annotation module,...
Medical image segmentation represents a pivotal and intricate procedure in the domain of medical processing analysis. With progression artificial intelligence recent years, utilization deep learning techniques for has witnessed escalating popularity. Nevertheless, nature poses challenges on diminutive targets is still its early stages. Current networks encounter difficulties addressing exceedingly small targets, especially when number training samples limited. To overcome this constraint, we...
Asiatic acid (AA) is a pentacyclic triterpene in Centella asiatica known to inhibit proliferation and induce apoptosis several tumor cell lines. In the current study, we synthesized five AA derivatives examined their inhibitory activities on growth non-small lung cancer lines, A549 PC9/G. Four were found have stronger activity than AA. Among them, compound A-3 showed most significant antiproliferative effects tumor. Growth of PC9/G cells was inhibited by dose- time-dependent manner. To...
A large number of bioactive pentacyclic triterpenoids have been shown to multiple biological activities. This study was conducted evaluate the inhibitory activities 6 newly synthesized and novel against enterovirus 71 (EV71). The parent compound, ursolic acid (UA), showed greatest activity EV71, while oleanolic (OA), asiatic (AA), synthetic derivatives 18-β-glycyrrhetinic (GA) OA also exhibited effects, although lesser extents. results suggest these compounds show potential for further...
In the present paper, we report biochemical characterization of a chromosomal toxin–antitoxin (TA) system in Mycobacterium tuberculosis , consisting Rv1991c gene and its upstream open reading frame (ORF) termed Rv1991a . was characterized as toxin with ribonuclease activity antitoxin against Rv1991c. interacted to form complex. A promoter located immediately identified. Both Rv1991a–Rv1991c complex were able bind region operon, indicating that expression operon can be autoregulated.
Nineteen isosteviol derivatives were designed and synthesized by C-16, C-19 D-ring modifications of isosteviol. These compounds screened for their cytotoxic activities against Hela A549 cells in vitro. Among them, the inhibitory effect 3b 16 on was comparable to that positive control gefitinib, (IC50=7.84 ± 0.84 μM) 7a (IC50=6.89 0.33 exhibited significant cytotoxicity superior gefitinib (IC50=11.02 3.27 cells.
To overcome the metabolic instability of cordycepin (adenosine deaminase (ADA) deamination and plasma degradation) obtain better bioactivity, three novel kinds derivatives 1a-1c containing unsaturated fatty acids including linoleic acid, arachidonic acid α-linolenic respectively, were designed synthesized. In terms antibacterial activity, synthesized compounds 1a 1c showed enhanced activity than in tested bacterial strains. also exhibited antitumor against four cancer cell lines (human...
A series of 2-substituted-7-heptyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-1(2H)-ones was synthesized. The anticonvulsant effect and neurotoxicity the compounds were calculated with maximal electroshock (MES) test, subcutaneous pentylenetetrazole (sc-PTZ), rotarod tests intraperitoneally injected mice. Among synthesized compounds, 2-propionyl-7-heptyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1(2H)-one 4b most active one also had lowest toxicity. In anti-MES potency it showed...
Twelve novel cordycepin derivatives were designed and synthesized with modification at positions of 2′, 5′-hydroxyl N6 amino groups cordycepin. The results showed that the inhibitory activities 3, 4b, 6c 6d on A549 comparable to positive control gefitinib, activity 6a was better than gefitinib. Also, twelve against E. coli 1924, S. aureus 4220 mutans 3289 studied. Among them, 4b certain 3289, while 6b inhibition 4220.
A series of quercetin derivatives were synthesized via Williamson etherification, Steglich esterification or Koenigs–Knorr glycosylation reaction at 3 and 7 position hydroxyl groups selectively. The structures the compounds characterized identified by IR, 1H NMR, 13C NMR HR-MS. antioxidant capacity was determined total assay kit with ABTS method (T-AOC Assay Kit). results revealed that Qr-5a, Qr-5b, Qr-5c, Qr-5d Qr-12 manifested significant activities comparing to positive control rutin...