A5088008829- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Bioactive Natural Diterpenoids Research
- Metabolomics and Mass Spectrometry Studies
- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Traditional and Medicinal Uses of Annonaceae
- Essential Oils and Antimicrobial Activity
- Phytochemical compounds biological activities
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemicals and Antioxidant Activities
- Air Quality and Health Impacts
- Immune Response and Inflammation
- Toxic Organic Pollutants Impact
- Advanced Glycation End Products research
- Sesquiterpenes and Asteraceae Studies
- Oral microbiology and periodontitis research
- Nuts composition and effects
- Marine Sponges and Natural Products
- Plant Toxicity and Pharmacological Properties
- Pharmacological Effects of Natural Compounds
- Mercury impact and mitigation studies
- Phytochemical Studies and Bioactivities
- Plant-derived Lignans Synthesis and Bioactivity
Yanbian University
2016-2025
Chongqing Medical University
2023-2025
Children's Hospital of Chongqing Medical University
2023-2025
Broad Institute
2023-2024
Research Center for Eco-Environmental Sciences
2024
Chinese Academy of Sciences
2006-2024
University of Chinese Academy of Sciences
2006-2024
Tibet University
2024
Shandong University of Science and Technology
2024
University of Waterloo
2024
Four types of dust samples and nine categories locally produced staple foods were collected from a mega e-waste recycling industrial park its surrounding regions, simultaneously analyzed for short-chain medium-chain chlorinated paraffins (CPs) to estimate dietary exposure their combined effects on occupational workers local residents. All related activities contained considerably high concentrations CPs. The highest concentration was found in workshops. CPs highly accumulated plant animal...
Mesenchymal stem cell (MSC)-mediated tissue regeneration offers opportunities to regenerate a bio-root and its associated periodontal tissues restore tooth loss. Previously, we proved that the apical end of developing root was acting as promising candidate source for root/periodontal (R/PT) regeneration. In present study, investigated properties periapical follicle cells (PAFSCs) isolated from human third molars at root-developing stage evaluated potential application these...
Summary Late-onset Alzheimer’s disease is a prevalent age-related polygenic that accounts for 50-70% of dementia cases 1 . caused by combination many genetic variants with small effect sizes and environmental influences. Currently, only fraction the underlying have been identified 2,3 Here we show increased sample allowed identification seven novel loci contributing to disease. We highlighted eight potentially causal genes where gene expression changes are likely explain association. Human...
Neonicotinoid insecticides (NEOs) are widely used around the world. The distribution of NEOs in paired saliva and periodontal blood samples was not previously documented China. In this study, concentrations six three corresponding metabolites were measured 188 collected from South their frequently detected (68–94%) blood, with median levels 0.01–0.99 ng/mL. 1-Methyl-3-(tetrahydro-3-furylmethyl) urea most predominant NEO (39%) (42%). Gender-related differences metabolite found: males showed...
Two new phytoecdysteroids, (24Z)-20,26-dihydroxy-24(28)-dehydro-28-methyl-ecdysone (1), (24Z)-22,25-epoxy-2,3,14,20-tetrahydroxyergosta-7,24(28)-dien-28-methyl-6-one (2), together with eleven known compounds (3 − 13) were isolated from the whole plant of Tournefortia sibirica L. The chemical structures elucidated by 1D and 2D NMR HR-ESI-MS compared data literature. evaluated for their inhibitory effects on NO, TNF-α IL-6 production in LPS-induced RAW 264.7 cells. Among them, 6, 7, 9, 10...
Given that the preparation method of polysaccharides affects functional properties, four types acidic (BCP30-1a, BCP50-1a, BCP70-1a, and BCP90-1a) were prepared using gradient ethanol precipitation method. Then, a series chemical instrumental analysis techniques used to compare structural characteristics morphology. Neuroprotective effects explored OGD/R-induced PC12 cells. The results showed BCP30-1a, BCP90-1a had similar characteristic groups contained both β-glycosidic α-glycosidic bonds....
Placental abruption, a rare disorder of unclear etiology, lacks evidence to illustrate its relationship with exposure air pollution and temperature. To investigate the association between ambient pollutants temperatures placental so as identify susceptible time windows subpopulations. A nested case-control study was based on live birth registration database in Chongqing, largest Chinese municipality China, from 2018 2022. The abruption cases were each matched four controls by maternal age at...
Lyngbyatoxin A from the marine cyanobacterium Moorea producens (formerly Lyngbya majuscula) is known as causative agent of "swimmer's itch" with its highly inflammatory effect. new toxic compound was isolated along lyngbyatoxin an ethyl acetate extract M. collected Hawaii. Analyses HR-ESI-MS and NMR spectroscopies revealed had same planar structure that A. The results optical rotation CD spectra indicated a derivative, 12-epi-lyngbyatoxin (1). While showed comparable toxicities in...
1. Absorption, distribution, metabolism, transport and elimination properties of omadacycline, an aminomethylcycline antibiotic, were investigated in vitro a study healthy male subjects. 2. Omadacycline was metabolically stable human liver microsomes hepatocytes did not inhibit or induce any the nine cytochrome P450 five transporters tested. substrate P-glycoprotein, but other transporters. 3. metabolic stability confirmed six subjects who received single 300 mg oral dose [14C]-omadacycline...
Chlorinated paraffins (CPs) are now attracting special concerns worldwide as one type of new persistent toxic substances classified by the Stockholm Convention. CPs extensively applied in household goods and indoor decoration materials, but information on their occurrence exposure risk such environments is still very scarce. In this study, current concentrations, particle size distributions, inhalation characteristics were investigated regard to air particulate matter. Both short chain...
Rapid social-economic development introduces modern lifestyles into rural areas, not only bringing numerous products but also new pollutants, such as chlorinated paraffins (CPs). The Tibetan Plateau has limited industrial activities and is a unique place to investigate this issue. Herein we collected 90 free-range chicken egg pool samples across the evaluate pollution status of CPs. Meanwhile, CPs in related soils, eggs from Jiangxi, farmed markets were analyzed. median concentrations SCCPs...