A5100318001- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Pharmacological Effects of Natural Compounds
- Eicosanoids and Hypertension Pharmacology
- Traditional Chinese Medicine Studies
- Free Radicals and Antioxidants
- Medicinal Plant Pharmacodynamics Research
- NF-κB Signaling Pathways
- Marine Sponges and Natural Products
- Neurological Disease Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Traditional Chinese Medicine Analysis
- Tryptophan and brain disorders
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Seaweed-derived Bioactive Compounds
- Healthcare and Venom Research
- Immune Cell Function and Interaction
- Traumatic Brain Injury and Neurovascular Disturbances
- Traditional and Medicinal Uses of Annonaceae
- interferon and immune responses
General Hospital of Shenyang Military Region
2025
Korea Institute of Oriental Medicine
2016-2024
Seventh People's Hospital of Shanghai
2024
Xihua University
2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2018-2024
Peking University
2007-2024
Qingdao University
2023-2024
Second Affiliated Hospital of Zhejiang University
2017-2024
Southwest Medical University
2024
Zhengzhou University
2024
Purpose Microglia represent the primary resident immune cells in CNS, and have been implicated pathology of neurodegenerative diseases. Under basal or "resting" conditions, microglia possess ramified morphologies exhibit dynamic surveying movements their processes. Despite prominence this phenomenon, function regulation microglial morphology behavior are incompletely understood. We investigate here whether how neurotransmission regulates behavior. Methods employed an ex vivo mouse retinal...
Microglia are known as resident immune cells in the brain. β-amyloid (Aβ) plaques brain of Alzheimer's disease (AD) surrounded by microglia, but whether and how microglia affect formation maintenance remains controversial. We depleted injecting diphtheria toxin (DT) CX 3 CR1 CreER/+ :R26 DTR/+ (CX CR1-iDTR) mice crossed with APPswe/PSEN1dE9 (APP/PS1) mice. Intravital time-lapse imaging was performed to examine changes number size Congo Red-labeled amyloid over 1–2 weeks. also examined spine...
Tissue damage and cellular destruction are the major events in traumatic brain injury (TBI), which trigger sterile neuroimmune neuroinflammatory responses brain. While appropriate acute transient facilitate repair adaptation of injured tissues, prolonged excessive exacerbate damage. The mechanisms that control intensity duration TBI largely remain elusive.We used controlled cortical impact (CCI) model to study role immune checkpoints (ICPs), key regulators homeostasis, regulation vivo.We...
Abstract Ischemic stroke is a clinical syndrome caused by the disruption of blood flow into cerebral tissues and associated with high disability mortality rates. Studies have established pathological role platelets in ischemia/reperfusion (I/R) injury, although underlying mechanism action remains largely unclear. In this study, we created an I/R mouse model via middle artery occlusion reperfusion (MCAO/R) analyzed transcriptomic profiles ipsilateral contralateral cortices using RNA-seq. We...
Astrocytes and microglia play an orchestrated role following spinal cord injury; however, the molecular mechanisms through which regulate astrocytes after injury are not yet fully understood. Herein, were pharmacologically depleted effects on astrocytic response examined. We further explored potential involving signal transducers activators of transcription 3 (STAT3) pathway. For in vivo experiments, we constructed a contusion model C57BL/6 mice. To deplete microglia, all mice treated with...
Herpes simplex virus type 1 (HSV-1), known to latently infect the host's trigeminal ganglion, can lead severe herpes encephalitis or asymptomatic infection, potentially contributing neurodegenerative diseases like Alzheimer's. The generates reactive oxygen species (ROS) that significantly impact viral replication and induce chronic inflammation through NF-κB activation. Nuclear factor E2-related 2 (Nrf2), an oxidative stress regulator, prevent treat HSV-1 infection by activating passive...
Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was investigate underlying ganoderma oxidative stress-induced neuronal apoptosis. Hydrogen peroxide (H2O2) used induce cultured cerebellar granule cells. In these cells, remarkably suppressed H2O2-induced apoptosis, decreased expression caspase-3, Bax and Bim increased that Bcl-2. These findings suggested...
Microglial activation and the resulting neuroinflammation are associated with a variety of brain diseases, such as Alzheimer’s disease Parkinson’s disease. Thus, control microglial is an important factor in development drugs that can treat or prevent inflammation-related neurodegenerative disorders. Atractylodis Rhizoma Alba (ARA) has been reported to exhibit antioxidant, gastroprotective, anti-inflammatory effects. However, effects ARA ethanolic extract (ARAE) on microglia-mediated have not...
Modulation of mitochondrial function through inhibiting respiratory complex I activates a key sensor cellular energy status, the 5'-AMP-activated protein kinase (AMPK). Activation AMPK results in mobilization nutrient uptake and catabolism for ATP generation to restore homeostasis. How these pathways are affected presence potent modulator role activation effects remain unclear. We have identified molecule, named R419, that vitro via inhibition at much lower concentrations than metformin...
The bark of Rhus verniciflua Stokes (RVS) has been used to treat cancer in Korean herbal medicine. When we screened for PD-1 and CTLA-4 immune checkpoint inhibitors (PD-1/PD-L1 CTLA-4/CD80) from around 800 extracts using competitive Enzyme-Linked Immunosorbent Assay (ELISA), found that RVS blocked both the PD-1/PD-L1 CTLA-4/CD80 interactions. To identify active compounds RVS, performed bioactivity-guided fractionation, ethyl acetate (EtOAc) fraction proved be most effective at blocking In...
Ten new p-terphenyl derivatives, floricolins A-J (1-10), together with six known compounds (11-16), were isolated from the extract of endolichenic fungus Floricola striata. Chemical structures these elucidated using spectroscopic data (HRESIMS and NMR). Among them, 9 10 enantiomeric mixtures, their configurations established by single-crystal X-ray diffraction analysis Cu Kα radiation. Evaluation against Candida albicans revealed that most active compound, 3 (MIC 8 μg/mL), exerted fungicidal...
Microglia are diverse cells that acquire different functional phenotypes in response to microenvironment which they reside. Several transcriptional regulators have been identified regulate microglia phenotypes. They mainly stimulated into two opposing phenotypes, classically (M1) and alternatively (M2) phenotype. Regulating polarization from M1 M2 state has suggested as a potential therapeutic approach treatment of CNS disorders. Candesartan, an angiotensin II type I receptors antagonist,...