A5101809149- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Graphene and Nanomaterials Applications
- Global Cancer Incidence and Screening
- Non-Destructive Testing Techniques
- Catalysis and Hydrodesulfurization Studies
- Cancer Risks and Factors
- Biosimilars and Bioanalytical Methods
- Liver Diseases and Immunity
- Microtubule and mitosis dynamics
- Pediatric Hepatobiliary Diseases and Treatments
- Vehicle emissions and performance
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Microstructure and Mechanical Properties of Steels
- Protein purification and stability
- Maritime Transport Emissions and Efficiency
- Metallurgical Processes and Thermodynamics
- Supramolecular Self-Assembly in Materials
- Extraction and Separation Processes
- Immune cells in cancer
- Endometrial and Cervical Cancer Treatments
- Autoimmune and Inflammatory Disorders
Shandong Provincial Hospital
2025
Shandong University
2025
Qilu Hospital of Shandong University
2025
Southern Medical University
2024
Nanjing Medical University
2022-2024
Shanghai Ocean University
2023-2024
Zhujiang Hospital
2024
Suzhou Municipal Hospital
2024
Northwest University
2024
Shaanxi University of Technology
2024
Abstract Ischemic stroke is a clinical syndrome caused by the disruption of blood flow into cerebral tissues and associated with high disability mortality rates. Studies have established pathological role platelets in ischemia/reperfusion (I/R) injury, although underlying mechanism action remains largely unclear. In this study, we created an I/R mouse model via middle artery occlusion reperfusion (MCAO/R) analyzed transcriptomic profiles ipsilateral contralateral cortices using RNA-seq. We...
Abstract Background Ovarian cancer (OC) has the highest mortality rate among all gynecological malignancies. A hypoxic microenvironment is a common feature of solid tumors, including ovarian cancer, and an important driving factor tumor cell survival chemo- radiotherapy resistance. Previous research identified hypoxia-associated gene angiopoietin-like 4 (ANGPTL4) as both pro-angiogenic pro-metastatic in tumors. Hence, this work aimed to further elucidate contribution ANGPTL4 OC progression....
Quantifying structural damage using online monitoring data is crucial for condition-based maintenance to ensure aviation safety. However, most data-driven methods hardly use accumulated domain knowledge, making it difficult address parameter variability across different structures due manufacturing as well compromising result interpretability. To these challenges, this study proposes a physics-decoded variational neural network quantification and model calibration. The innovation of method...
Background Bronchiolar adenoma (BA) is a rare benign tumor originating in the bronchial mucosal epithelium and occurring primarily periphery of lung. The most prominent histopathological feature BA double-layer containing continuous basal cell layers. However, due to high mutation frequency driver gene, there still debate as whether has potential for malignant transformation. In frozen sections, cells are difficult identify under microscope, which makes it distinguish from mucinous...
Abstract Cervical cancer remains a major public health challenge worldwide, despite being largely preventable through effective interventions. Timely evidence regarding the global landscape of cervical is crucial for measuring magnitude inequalities and monitoring progress towards elimination. We aimed to provide an updated overview burden using GLOBOCAN 2022 database. Age‐standardized rates incidence mortality were presented according countries, 20 United Nations‐defined world regions,...
Malignant gliomas are one of the most common and lethal brain tumors with poor prognosis. Most patients glioblastoma (GBM) die within 2 years diagnosis, even after receiving standard treatments including surgery combined concomitant radiotherapy chemotherapy. Temozolomide (TMZ) is first-line chemotherapeutic agent for gliomas, but frequent acquisition chemoresistance generally leads to its treatment failure. Thus, it’s urgent investigate strategies overcoming glioma chemoresistance....
The enriched collagens in the extracellular matrix (ECM) of breast cancer substantially impede drug delivery. Halofuginone (HF), a potent antifibrotic agent, was effective to deplete and remodel ECM by inhibiting TGFβ pathway. However, application HF hindered its strong liver toxicity. Herein, mesoporous platinum (mPt) nanoparticles were constructed load as theranostic nanoplatforms. mPt had uniform spherical structure with diameter 79.83 ± 6.97 nm an average pore 20 exhibited good...
<title>Abstract</title> Background: Visceral obesity elevates high-grade serous carcinoma (HGSOC) risk and prognosis but its effect on biology is underexplored. This study examines obesity-related genes (VORGs) in HGSOC. Methods Using consensus clustering, we analyzed TCGA GSE53963 datasets with VORGs, uncovering unique immune cell patterns gene functions. Our prognostic model integrates OS, tumor immunity, ICI response, chemotherapy outcomes. Single-cell data enrich our understanding of...
e22516 Background: Incidence and mortality of uterine cancer has reported to be declining. However, trends endometrial serous carcinoma remain unclear at a population level. Methods: We applied SEER evaluate uterine-serous- relevant deaths this disease incident cases. assessed based on specific causes races. were evaluated ethics calendar year. Trends incidence incidence-based by Joinpoint software. Results: decreased 1.51% from 2000 through 2017, followed increase 16.58% 2017 2019....
Based on the survey of 175 synthetic leather enterprises in Zhejiang Province, China, 2014, this paper analyzes control volatile organic compounds (VOCs) and, ultimately, screened 161 key for further research. The results showed that most take measures to waste gas; however, there is a distinct problem with efficiency exhaust gas collection. industry used Solvent-based materials. main VOC pollutants were DMF, toluene, methyl acetate, acetone, ethylacetate, and butanone. emission coefficient...
In this study, the critical need for precise and accurate prediction of intra‐tumor heterogeneity related to enhanced permeability retention effect spatial distribution nanoprobes is addressed development effective nanodrug delivery strategies. Current predictive models are limited in terms resolution accuracy, prompting construction a high‐resolution network (HRPN) that estimates microdistribution quantum dots, factoring tumor vascular nuclear features. The HRPN algorithm trained using 27...
Chemotherapy combined with immunotherapy plays a synergistic role to enhance the effectiveness of cancer treatment. However, it is great challenge deliver drugs accurately and efficiently target exert effects. Here, we report novel size-variable three-dimensional mesh nanocluster (HA/P-A cluster) formed by bifunctional peptide R14 cross-linking for tumor targeted co-delivery doxorubicin (DOX) pPD-L1 trap. The ERP effect targeting outer layer HA synergistically mediated accumulation...
The combination of chemotherapy and immunotherapy plays a synergistic role in improving the effectiveness cancer treatment. However, it is great challenge to deliver drugs accurately efficiently target exert effects due multiple biological obstacles vivo. Here, we constructed novel size-variable three-dimensional mesh nanocluster (HA/P-A cluster) cross-linked by bifunctional peptide R14 for tumor targeted co-delivery doxorubicin (DOX) pPD-L1 trap. ERP effect targeting outer layer HA...
Abstract Background The diagnosis of Crohn’s disease is challenging. This study aimed to compare the histological features and non-Crohn’s (i.e., other intestinal inflammatory diseases) in surgical specimens identify histologic for differential diagnosis. Methods We evaluated patients who were diagnosed with (n = 171) 215) between 2010 2015 underwent bowel resection. frequency resection compared these two patient groups. Results Transmural inflammation, subserosal lymphoid aggregates,...