A5102872731- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Spaceflight effects on biology
- Hydrogels: synthesis, properties, applications
- Nerve injury and regeneration
- Long-Term Effects of COVID-19
- Circadian rhythm and melatonin
- Respiratory Support and Mechanisms
- Stroke Rehabilitation and Recovery
- Spinal Cord Injury Research
- RNA modifications and cancer
- Microfluidic and Capillary Electrophoresis Applications
- COVID-19 Clinical Research Studies
- Curcumin's Biomedical Applications
- Mesoporous Materials and Catalysis
- Cardiac Ischemia and Reperfusion
- Advanced Polymer Synthesis and Characterization
- Botulinum Toxin and Related Neurological Disorders
- Immune cells in cancer
Capital Medical University
2014-2025
China Rehabilitation Research Center
2019-2025
Beijing Institute of Technology
2011-2023
Beijing Tsinghua Chang Gung Hospital
2023
Beijing Shijingshan Hospital
2023
Qilu Hospital of Shandong University
2023
Capital University
2021
Beijing Luhe Hospital Affiliated to Capital Medical University
2014-2019
AZ Sint-Lucas
2016
Neurological Surgery
2015
Microglia and infiltrated macrophages play important roles in inflammatory processes after ischemic stroke. Modulating microglia/macrophage polarization from pro-inflammatory phenotype to anti-inflammatory state has been suggested as a potential therapeutic approach the treatment of Melatonin shown be neuroprotective experimental stroke models. However, effect melatonin on microglia underlying mechanisms remain unknown.In vivo, cerebral ischemia was induced by distal middle artery occlusion...
NLRP3 inflammasome-mediated pyroptosis is a proinflammatory programmed cell death pathway, which plays vital role in functional outcomes after stroke. We previously described the beneficial effects of curcumin against stroke-induced neuronal damage through modulating microglial polarization. However, impact on remains unknown. Here, stroke was modeled mice by middle cerebral artery occlusion (MCAO) for 60 minutes and treated with (150 mg/kg) intraperitoneally immediately reperfusion,...
Delayed thrombolytic treatment with recombinant tissue plasminogen activator (tPA) may exacerbate blood-brain barrier breakdown after ischaemic stroke and lead to lethal haemorrhagic transformation. The immune system is a dynamic modulator of response, excessive cell accumulation in the cerebral vasculature associated compromised integrity barrier. We previously reported that regulatory T cells, which function suppress responses, ameliorated damage ischaemia. This study assessed impact cells...
Stroke is the most common type of cerebrovascular disease and a leading cause disability death. Ischemic stroke accounts for approximately 80% all strokes. The remaining 20% strokes are hemorrhagic in nature. To date, therapeutic options acute ischemic very limited. Recent research suggests that shifting microglial phenotype from pro-inflammatory M1 state toward anti-inflammatory tissue-reparative M2 may be an effective strategy stroke. dietary phytochemical curcumin has shown promise...
Summary Aims Remote ischemic preconditioning ( RIPC ) of a limb is clinically feasible strategy to protect against ischemia–reperfusion injury after stroke. However, the mechanism underlying remains elusive. Methods We generated rat model noninvasive by four repeated cycles brief blood flow constriction (5 min) in hindlimbs using tourniquet. Blood was collected 1 h and 3 days brain reperfusion. The impact on immune cell cytokine profiles prior transient middle cerebral artery occlusion MCAO...
Abstract Spinal cord injury (SCI) is a devastating neurological disorder, but few drugs have proven to be effective for its treatment. Neuroinflammation exaggerates the secondary subsequent trauma. Emerging evidence suggests that melatonin may help protect neural tissue against after SCI, underlying mechanisms remain elusive. Microglial/macrophages polarization plays an important role in regulating immune responses. To examine whether exerts neuroprotective effects acute SCI by...
Remote ischemic preconditioning (RIPC) of a limb has been reported to protect against stroke. Our previous results demonstrated that the RIPC-mediated neuroprotection is associated with alterations in circulating immune cell populations. Here, we evaluated effect spleen, largest reservoir cells, on Noninvasive RIPC was achieved by four repeated cycles 5-min blood flow constriction hindlimbs using tourniquet. The and spleens were collected before 1 h 3 days after analyze spleen correlation...
Splenectomy before or immediately after stroke provides early brain protection. This study aims to explore the effect of splenectomy on long-term neurological recovery stroke, which is currently lacking in field. Adult male rats were randomized into sham groups and then subjected 90 min middle cerebral artery occlusion (MCAO). Spleen was removed right upon reperfusion 3d MCAO. Infarct volume, functions, peripheral immune cell populations assessed up 28d stroke. The results show that delayed...
Microglia are diverse cells that acquire different functional phenotypes in response to microenvironment which they reside. Several transcriptional regulators have been identified regulate microglia phenotypes. They mainly stimulated into two opposing phenotypes, classically (M1) and alternatively (M2) phenotype. Regulating polarization from M1 M2 state has suggested as a potential therapeutic approach treatment of CNS disorders. Candesartan, an angiotensin II type I receptors antagonist,...
Background and Purpose— Ischemic stroke induces metabolic disarray. A central regulatory site, pyruvate dehydrogeanse complex (PDHC) sits at the cross-roads of 2 fundamental pathways: aerobic anaerobic. In this study, we combined ethanol (EtOH) normobaric oxygen (NBO) to develop a novel treatment modulate PDHC its proteins, namely dehydrogenase phosphatase kinase, leading improved metabolism reduced oxidative damage. Methods— Sprague–Dawley rats were subjected transient (2, 3, or 4 hours)...
JOURNAL/nrgr/04.03/01300535-202503000-00032/figure1/v/2025-03-16T133445Z/r/image-tiff Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Sal) is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, an environmental toxin Parkinson’s disease. However, the mechanism by which Sal mediates dopaminergic neuronal death remains unclear. In this study, we found significantly enhanced global level of N 6...
Stroke has high mortality and morbidity. Biomarkers are required for to predict stroke outcomes, which could help clinicians provide rationale approaches patient management. The dynamic changes in circulating immune cells have been reported patients animal models of stroke.The aim this study was explore biomarkers outcomes by investigating the relationship between frequencies outcomes.In all, 50 acute ischemic (AIS) were enrolled. Their blood samples collected upon hospital admission on day...