A5100390619- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Medicinal Plants and Neuroprotection
- Medicinal Plants and Bioactive Compounds
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Plant-derived Lignans Synthesis and Bioactivity
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Acute Ischemic Stroke Management
- Phytochemistry and Biological Activities
- Nicotinic Acetylcholine Receptors Study
- Cerebrovascular and Carotid Artery Diseases
- NF-κB Signaling Pathways
- Infrared Thermography in Medicine
- Cardiovascular Disease and Adiposity
- Mental Health Research Topics
- Genomics, phytochemicals, and oxidative stress
- Muscle activation and electromyography studies
- Ginseng Biological Effects and Applications
- Barrier Structure and Function Studies
Xinjiang Normal University
2025
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Yan'an University
2022
Nantong University
2021
Peking University First Hospital
2004-2018
Peking University
2004-2018
Beijing Tian Tan Hospital
2018
Capital Medical University
2018
Shanghai Ninth People's Hospital
2017
Microglial-mediated neuroinflammation has been established as playing a vital role in pathogenesis of neurodegenerative disorders. Thus, rational regulation microglia functions to inhibit inflammation injury may be logical and promising approach disease therapy. The purposes the present study were explore neuroprotective effects potential molecular mechanism Schizandrin A (Sch A), lignin compound isolated from Schisandra chinesnesis. Our observations showed that Sch could significantly...
Background:We investigated whether the anti-atherosclerosis of adiponectin (APN) relates to reduction oxidative stress. We observed overexpression gene with different titers on atherosclerosis (AS) models high-fat apolipoprotein E-deficient (ApoE–/–) mice. Material andMethods:We divided 48 male ApoE–/– mice into 4 groups: control group, diet low and high group. The group were treated recombinant adenovirus expressing (Ad-APN) low-dose 1.0×108 p.f.u. high-dose 5.0×108 via tail every 2 weeks...
Abstract Interleukin-33 (IL-33), an emerging cytokine within the IL-1 family, assumes a pivotal function in control of obesity. However, specific mechanism its regulation obesity formation remains unclear. In this study, we found that expression level IL-33 increased visceral adipose tissue mice fed with high-fat diet (HFD) compared normal (ND). vitro, also was upregulated during adipogenesis 3T3-L1 cells. Functional test results showed knockdown cells differentiation could promote...
ABSTRACT Given that Sentinel‐2 (S2) multispectral images provide extensive spatial information and ground‐based hyperspectral data capture refined spectral characteristics, their integration can enhance both the comprehensiveness precision of surface acquisition. This study seeks to leverage these sources develop an optimized estimation model for accurately monitoring large‐scale soil organic carbon (SOC) content, thereby addressing current limitations in multi‐source fusion research. In...
Stroke has high mortality and morbidity. Biomarkers are required for to predict stroke outcomes, which could help clinicians provide rationale approaches patient management. The dynamic changes in circulating immune cells have been reported patients animal models of stroke.The aim this study was explore biomarkers outcomes by investigating the relationship between frequencies outcomes.In all, 50 acute ischemic (AIS) were enrolled. Their blood samples collected upon hospital admission on day...
Type 2 Diabetes mellitus (T2DM) is closely correlated with cognitive impairment and neurodegenerative disease. Bushen Huoxue (BSHX) a compound Chinese medicine used clinically to treat diabetes-induced impairment. However, its underlying mechanisms remain unclear. In the present study, KKAy mice, genetic model of type diabetes obesity insulin resistant hyperglycemia, received daily administration BSHX for 12 weeks. Blood glucose was measured every four After weeks, treatment significantly...
The association between intracranial internal carotid artery (IICA) calcification and lacunes, white matter hyperintensity (WMH), cerebral microbleeds (CMBs) has been well researched. However, enlarged perivascular space (PVS) not yet reported to correlate with calcification. Therefore, the primary aim of this study was investigate relationship IICA PVS.A total 189 patients ischemic stroke in middle territory who presented within 7 days ictus from 2012 2015 were enrolled respectively. All...
Modified Wu-Zi-Yan-Zong prescription (MWP), a traditional Chinese medicinal decoction, has possessed the neuroprotective and anti-inflammatory properties. The mechanisms associated with these properties, however, are not completely understood. We designed experiments to elucidate antineuroinflammatory property of MWP in BV2 microglia activated by β-amyloid (Aβ), which is characteristic feature Alzheimer's disease (AD). composition was studied using HPLC. cells were then treated Aβ presence...
This study aimed to explore the efficacy of zunyimycin C in immunological enhancement hypoimmune mice and improvement cognitive impairment a model Alzheimer’s disease (AD). Zunyimycin was administered intranasally interfere with AD mouse models or gavage animals. Results Morris water maze (MWM) showed that may improve learning memory abilities model. The results differential expression analysis mRNA levels inflammatory factors pathways brain tissues suggested more obvious under Zun-Int L....
The injury of exogenous formaldehyde and its merchanism have attracted wide attention from researchers. latest study found that mammals a whole system for generating clearning formaldehyde. However, the imbalance on various reasons will cause abnormal accumulation endogenous in vivo, which is closely related to learning diability memory dysfunction. increase concentration may be one factors inducing such neurodegenerative diseases as Alzheimer's disease. relationship between disease great...
Targets group identification in complex Chinese medicine system is a key step for revealing the potential mechanism of medicine. The solid beads with magnetic core and benzophenone-modified surface were made our study, then benzophenone was activated cross-linked C-H bonds chemical compositions medicines under UV excitation. Thus modified Wuzi Yanzong pill(MWP) linked to bead surface, enriched neuroprotective targets MWP after being co-incubated nerve cell lysate. We performed proteomics...