A5100322163- Neurological Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Associations and Epidemiology
- Trigeminal Neuralgia and Treatments
- Neurological Disorders and Treatments
- Cerebrovascular and genetic disorders
- Infrastructure Resilience and Vulnerability Analysis
- GDF15 and Related Biomarkers
- Salivary Gland Disorders and Functions
- Intracerebral and Subarachnoid Hemorrhage Research
- Evacuation and Crowd Dynamics
- Cerebrovascular and Carotid Artery Diseases
- Eating Disorders and Behaviors
- Atherosclerosis and Cardiovascular Diseases
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Vestibular and auditory disorders
- Medicinal Plants and Neuroprotection
- Eicosanoids and Hypertension Pharmacology
- Parkinson's Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Disaster Management and Resilience
- Sulfur Compounds in Biology
- Folate and B Vitamins Research
Beijing Normal University
2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023
Beijing University of Chinese Medicine
2023
National Natural Science Foundation of China
2023
North China University of Water Resources and Electric Power
2023
First Affiliated Hospital of Zhengzhou University
2019-2022
Yan'an University
2022
Fujian Medical University
2019
Second People's Hospital of Yunnan Province
2017
University of Iowa
2007
Abstract Background and purpose Previous studies have reported the association between frailty stroke or Alzheimer's disease (AD). However, causality remains unclear. The aim of present study was to evaluate whether genetically predicted is associated with risk AD by a Mendelian randomization (MR) study. Methods Genetic variants index (FI) were obtained from large genome‐wide (GWAS). Summary‐level data for adopted corresponding GWAS individuals European ancestry. inverse variance weighted...
Migraine is a primary headache characterized by moderate or severe attacks, accompanied with reversible neurological and systemic symptoms. There are rare biomarkers for the disease. While emerging evidence has indicated connection between gut microbiota migraine, relation oral migraine barely known. Thus, objective of current study was to explore possible correlation migraine. We compared communities patients (26) healthy subjects (29) via 16S rRNA gene sequencing. Alpha diversity indices...
Background Hydrogen sulphide (H 2 S) is considered as the third member of gasotransmitter family, along with nitric oxide (NO) and carbon monoxide. H S has been reported to induce angiogenesis by promoting growth, migration tube-like structure formation endothelial cells. Those studies were conducted in conditions cell culture, mouse Matrigel plug assay model, rat wound healing model or hindlimb ischaemia model. Recent vivo showed physiological importance muscle angiogenesis. However,...
Accumulating evidence indicates interleukin-1 (IL-1) is a critical mediator of inflammatory responses in ischemic stroke (IS). The aim this study was to investigate whether rs3783553 the 3'-untranslated region IL-1A associated with risk IS. In hospital-based case-control study, we genotyped using polymerase chain reaction 316 patients IS and 332 age, sex, ethnicity-matched controls. Plasma level IL-1α measured by enzyme-linked immunosorbent assay. relative luciferase activities were Dual...
Background : Homocysteine (Hcy) is a toxic amino acid and hyperhomocysteinemia (HHcy) was reported to be associated with both cerebrovascular disease neurodegenerative disease. Our aim assess the causal link between plasma Hcy level diseases through Mendelian randomization (MR) study. Methods A two-sample MR study performed infer link. We extracted genetic variants (SNPs) from large genome-wide association (GWAS) meta-analysis. The main analysis using inverse variance-weighted method....
This study aimed to explore the efficacy of zunyimycin C in immunological enhancement hypoimmune mice and improvement cognitive impairment a model Alzheimer’s disease (AD). Zunyimycin was administered intranasally interfere with AD mouse models or gavage animals. Results Morris water maze (MWM) showed that may improve learning memory abilities model. The results differential expression analysis mRNA levels inflammatory factors pathways brain tissues suggested more obvious under Zun-Int L....
Benign paroxysmal positional vertigo (BPPV) is a common, self-limited, and favorable prognostic peripheral vestibular disorder. BPPV transmitted in an autosomal dominant fashion, but most cases occur sporadically. Little research has been reported regarding the mutation spectrum of sporadic large cohort. This study attempted to identify causative candidate variants associated with VDR, LOXL1, LOXL1-AS1.An amplicon-targeted next-generation sequencing (NGS) method for LOXL1-AS1, was completed...
Background: Arterial stiffness index (ASI) is a potential risk factor for cerebrovascular and cardiometabolic diseases, but the causal links between them are inconclusive. The aim to evaluate effects of ASI on diseases by Mendelian randomization (MR). Methods: Two-sample MR analysis was performed infer links. Genetic variants significantly associated with were extracted. inverse variance weighted method used estimating effects. Sensitivity test heterogeneity or pleiotropy. Results: indicated...
Chronic migraine (CM) is a highly disabling neurological disorder characterized by recurrent headache accompanied variety of sensory and/or emotional symptoms. However, the mechanisms onset and its chronicity have not been elucidated. The present study was designed to search for brain regions neurons that were abnormally activated CM might be related pathogenesis different concomitant models established here repeated intraperitoneal injection nitroglycerin (NTG) every other day 9 days early...
Natural disaster response is commonly regarded as a dynamic process that reflects intricate relationships between physical and social factors. The resilience of infrastructure impacts the availability emergency resources, while asymmetric resource dependence among cooperation organizations influences effectiveness coordinated response. This study has formulated differential game encompassing three models: autonomous participation, government-led, collaborative These models have been designed...
Background: Lacunes and white matter hyperintensities (WMH) are two common findings seen on neuroimaging in patients with cerebral small vessel disease (cSVD). Clinically we observed that some cSVD have aphasia through the language assessment scale. Our study aimed to explore underlying risk factors for patients. Methods: This retrospectively analyzed 38 patients, without aphasia, aged 50 or over, Chinese Han population, diagnosed as lacunes and/or WMH. We collected demographic...
Objective To investigate the safety and short-term effect of endovascular treatment for high-risk patients chronic carotid artery occlusion. Methods We retrospectively analyzed data 12 with occlusion who were admitted to First Affiliated Hospital Xinjiang Medical University from October 2014 February 2016 underwent treatment. National Institute Health stroke scale(NIHSS)was used evaluate patients'neuronal functions.Follow-up studies conducted 1 week, 30 days 6 months post operations...
Effect-cause diagnosis procedures are the most commonly used in industry to diagnose VLSI circuits that fail manufacturing test or field applications. Fast and effective essential large numbers of failing dies for yield ramp-up. We have recently proposed a method speed up effect-cause by using dictionary small size [26]. In this paper we propose methods further reduce still achieve higher performance. Experiments on several industrial designs demonstrate that, average, can be speeded 3.5X...