A5062633473- Phytochemistry and Biological Activities
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Trigeminal Neuralgia and Treatments
- Transcranial Magnetic Stimulation Studies
- Migraine and Headache Studies
- Natural product bioactivities and synthesis
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Alzheimer's disease research and treatments
- Alkaloids: synthesis and pharmacology
- Advancements in Transdermal Drug Delivery
- Pediatric Pain Management Techniques
- Medicinal Plants and Neuroprotection
- Pain Management and Opioid Use
- Botulinum Toxin and Related Neurological Disorders
Renji Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
Xinjiang Institute of Materia Medica
2023
Northeast Agricultural University
2020
Lianyungang Oriental Hospital
2018
Xuzhou Medical College
2018
Lanzhou University
2018
Purpose: To investigate the risk factors associated with subclinical diabetic peripheral neuropathy (sDPN) in patients type 2 diabetes mellitus (T2DM). Patients and Methods: This cross-sectional, retrospective study involved 311 T2DM who were successively admitted from January 2018 to December 2021 without any neurological symptoms. All participants underwent a nerve conduction (NCS), those asymptomatic abnormal diagnosed sDPN. Differences between groups evaluated by chi-squared, Wilcoxon,...
Ketamine has become a popular recreational drug due to its neuronal anesthesia effect and low price. The process of learning memory is part the distinctive high-level neural activities in animals. We investigated effects subanesthetic anesthetic doses ketamine on memory-related signal transduction mechanisms. used Morris water maze test execute rats’ ability detected changes Arc mRNA Arc, cAMP-response element-binding protein (CREB), phospho-CREB (p-CREB), extracellular signal-regulated...
Abstract Alzheimer's disease (AD) is a neurodegenerative disease. Senile plaques and intracellular neurofibrillary tangles are pathological hallmarks of AD. Recent studies have described the improved cognitive neuroprotective functions acteoside (AS). This study aimed to investigate whether cognition AS was mediated by Aβ degradation tau phosphorylation in APP/PS1 mice. The open field, Y maze, novel object recognition tests were used assess behavioral changes. We evaluated levels Aβ40 Aβ42...
The analgesic effect on chronic pain of peripheral nerve stimulation (PNS) has been proven, but its underlying mechanism remains unknown. Therefore, this study aimed to assess the PNS bone cancer in a rat model and explore mechanism.PNS sciatic nerves with bipolar electrode was performed both naïve rats. Then, protein levels activity-regulated cytoskeleton-associated (Arc), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor 1 (GluA1), phosphate N-methyl-d-aspartic...
To study on the effect of acteoside learning and memory dementia mice.Mice were orally administered with for 10 days. Scopolamine was used to establish acquired disability in mice. Their detected a behavioral experiment (step-down test). After behavior test, corticocerebral hippocampus tissues mice biochemical indexes, including GSH-Px, T-SOD, MDA, TChE contents protein brain tissues.Mice d advance alleviate induced by scopolamine. Compared model group, increased latency period step-down...
Chronic migraine (CM) is a highly disabling neurological disorder characterized by recurrent headache accompanied variety of sensory and/or emotional symptoms. However, the mechanisms onset and its chronicity have not been elucidated. The present study was designed to search for brain regions neurons that were abnormally activated CM might be related pathogenesis different concomitant models established here repeated intraperitoneal injection nitroglycerin (NTG) every other day 9 days early...
Objective The differential proteins of hippocampal synapses in depression model rat was analyzed by two-dimensional gel electrophoresis.To provide clues for studies on the synaptic pathogenesis depression. Methods According to baseline sucrose consumption, 58 male Sprague-Dawley rats were divided into Chronic Mild Stress (CMS) and control groups randomly (n=29 per group). After establishment via CMS experimental mode, from prepared discontinuous density gradient...
Objective: Crosstalk between the brain and immune system has been implicated in dev elo pm e nt ofmental disorders. The hypothalamic pituitary adrenal axis serves as an important bridge forthis process. This study aims to investigate relationship fluctuation of plasmaglucocorticoid (GC) microglial activation ventral hippocampus during social defeat. Methods: Intruder—residen t paradigm was used establish rodent model acute de feat.The plasma GC intruder mice obtained serially after...