A5101778679- Adipose Tissue and Metabolism
- Telomeres, Telomerase, and Senescence
- Pain Management and Opioid Use
- Adipokines, Inflammation, and Metabolic Diseases
- Obstructive Sleep Apnea Research
- Cancer, Hypoxia, and Metabolism
- Pain Mechanisms and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diet and metabolism studies
- High Altitude and Hypoxia
- Tissue Engineering and Regenerative Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Mesenchymal stem cell research
- Mental Health and Psychiatry
- Metabolomics and Mass Spectrometry Studies
- Renin-Angiotensin System Studies
- Complementary and Alternative Medicine Studies
- Diet, Metabolism, and Disease
- Cardiovascular Health and Disease Prevention
- Receptor Mechanisms and Signaling
- Hematopoietic Stem Cell Transplantation
- Cancer, Stress, Anesthesia, and Immune Response
- Skin Protection and Aging
- Single-cell and spatial transcriptomics
- Respiratory Support and Mechanisms
Augusta University Health
2011-2024
Chinese Academy of Sciences
2023
Institute of Biophysics
2023
Nanjing Medical University
2014-2020
Guangzhou University of Chinese Medicine
2019
Kunming Medical University
2019
Jiangsu Province Hospital
2019
Lianyungang Oriental Hospital
2015-2018
Prevention Institute
2004-2016
St George's, University of London
2004
This study was performed to assess the effect of chronic intermittent hypoxia (CIH) on liver, associated mechanisms and potential therapeutic roles adiponectin (Ad). Sixty rats were randomly assigned four groups: normal control (NC), NC Ad supplement (NC + Ad), CIH, CIH (CIH Ad) groups. The in groups exposed a hypoxic environment for 4 months. Rats also treated with an intravenous injection (10 ug), twice week. plasma levels hepatic enzymes, serum triglyceride, liver fasting blood glucose...
The 825C>T polymorphism of the G-protein beta3-subunit gene (GNB3) has been associated with hypertension, although results are not entirely consistent. In a sample 282 female Caucasian dizygotic twins aged 21-80 years, we aimed to investigate associations between blood pressure and five single nucleotide polymorphisms (SNPs) including haplotypes GNB3 gene. (-350A>G, 657A>T, 814G>A, 1429C>T) were genotyped by polymerase chain reaction-restriction enzyme assays. Regular association tests did...
Background Genioglossal dysfunction is involved in the pathophysiology of obstructive sleep apnea hypoxia syndrome (OSAHS) characterized by nocturnal chronic intermittent (CIH). The genioglossal and possible targeted pharmacotherapy for alleviation injury CIH require further investigation. Methodology/Principal Findings Rats control group were exposed to normal air, while rats CIH+adiponectin (AD) same condition (CIH 8 hr/day 5 successive weeks). Furthermore, CIH+AD administrated intravenous...
Treating cancer pain continues to possess a major challenge. Here, we report that traditional Chinese medicine Xiao-Ai-Tong (XAT) can effectively suppress and adverse reactions following morphine treatment in patients with bone pain. Visual Analogue Scale (VAS) Quality of Life Questionnaire (EORTC QLQ-C30) were used for patient’s self-evaluation intensity evaluating changes including constipation, nausea, fatigue, anorexia, respectively, before after prescriptions. The clinical trials showed...
The analgesic effect on chronic pain of peripheral nerve stimulation (PNS) has been proven, but its underlying mechanism remains unknown. Therefore, this study aimed to assess the PNS bone cancer in a rat model and explore mechanism.PNS sciatic nerves with bipolar electrode was performed both naïve rats. Then, protein levels activity-regulated cytoskeleton-associated (Arc), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor 1 (GluA1), phosphate N-methyl-d-aspartic...
Vitamin D reportedly influences vascular function, which is worse in African Americans (AAs) relative to European (EAs). It not clear if ethnic differences 25(OH)D mediate function. This study examined the relationships of serum 25-hydroxyvitamin (25(OH)D) with indicators function among healthy, young AA and EA adults.This a cross sectional involving 23 AAs 22 EAs. The main outcomes were augmentation index (AIx75), central aortic pressure, pulse wave velocity (PWV), flow-mediated dilation...
Galanin and galanin receptors (GalRs) have been reported to be involved in the transmission modulation of nociceptive information central nervous system (CNS). However, underlying mechanism antinociception GalRs neuropathic pain remains unclear. This study investigated induced by receptor 1 (GalR1) via protein kinase A (PKA) signaling pathway nucleus accumbens (NAc) rats with pain. mononeuropathy model was replicated ligation left sciatic nerve, following which expression phospho-PKA (p-PKA)...
Radiotherapy is one of the major clinical approaches for treatment bone cancer pain. Activation cAMP-PKA signaling pathway plays important roles in Here, we examined effects radiotherapy on pain and accompanying abnormal activation signaling. Female Sprague-Dawley rats were used received tumor cell implantation (TCI) rat tibia (TCI model). Some that previously TCI treated with X-ray radiation (radiotherapy). Thermal hyperalgesia mechanical allodynia measured evaluating level caused by...
Objective Large population studies demonstrate that African Americans versus their Caucasian counterparts have a steeper decline in leukocyte telomere lengths (LTL) with age. Telomere shortening plays an important role cellular aging. Kallistatin, novel tissue kallikrein inhibitor, has anti‐inflammatory and anti‐oxidant properties. Recently we shown kallistatin inhibited vascular injury cell apoptosis animal models cultured cells. Thus aimed to test our hypothesis plasma levels are...
Objective To analyse differences in sex, age, depression, insomnia, psychological stress, resilience, and perceived social support among patients with medically unexplained symptoms (MUS) a clinic of general hospital, to explore the influencing factors MUS. Methods This is cross-sectional study. Seven hundred forty-six first-time were assessed integrated psychosomatic comprehensive evaluation system (IPS) evaluate their MUS, support. The characteristics compared regard sex age group...
Background: High sodium intake is a significant risk factor for hypertension and cardiovascular disease. Animal studies have demonstrated that high salt diet promotes tissue inflammation increases systemic inflammation, such it plausible induced might be another pathway to hypertension. However, whether the link between dietary systematic in humans remains unclear due limited human studies, different designs inconsistent findings. Therefore, we tested hypothesis reduction reduces by...
Objective: To explore the effect of adiponectin (APN) on islet injury induced by chronic intermittent hypoxia (CIH). Methods: Thirty-six SD rats were randomly divided into three groups: Normal control (NC), CIH, and CIH + APN groups. The in CIH+APN groups received an exposure while NC group room air only. intravenous injection APN. events persisted 8 hours a day last for 35 days. fasting blood glucose insulin detected at time 0, 7, 14, 21, 28, day. After days, level serum adiponectin,...
Introduction: Vascular aging, starting from youth, encompasses arterial degeneration and hardening that impairs vascular function, ultimately causes end-organ damage, predominantly in the heart, brain, kidney. Leucine (Leu) is an essential amino acid biosynthesis of proteins. It initially catalyzed to α-ketoisocaproate (α-KIC), then further metabolized β-hydroxy-β-methylbutyrate (HMB). Our prior work showed a significant decrease circulating HMB response additional sodium intake, key risk...