A5100442744- Nutrition and Health in Aging
- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- MicroRNA in disease regulation
- Stroke Rehabilitation and Recovery
- Body Composition Measurement Techniques
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebral Palsy and Movement Disorders
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Autophagy in Disease and Therapy
- Children's Physical and Motor Development
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- Health disparities and outcomes
- RNA modifications and cancer
- Environmental DNA in Biodiversity Studies
- Adipose Tissue and Metabolism
- Biofield Effects and Biophysics
- Sleep and related disorders
- RNA Research and Splicing
- Intracerebral and Subarachnoid Hemorrhage Research
- ECG Monitoring and Analysis
- Cardiac Health and Mental Health
First Affiliated Hospital of Kunming Medical University
2019-2025
Kunming Medical University
2019-2025
Krirk University
2024-2025
Capital Medical University
2020-2025
Guangdong Medical College
2020-2024
Sichuan University
2020-2024
Central China Normal University
2024
National Clinical Research Center for Digestive Diseases
2024
Temple University
2024
Xijing Hospital
2024
Objectives: Small-fiber polyneuropathy (SFPN) has various underlying causes, including associations with systemic autoimmune conditions. We have proposed a new cause; small-fiber-targeting diseases akin to Guillain-Barré and chronic inflammatory demyelinating (CIDP). There are no treatment studies yet for this ‘apparently SFPN’ (aaSFPN), but intravenous immunoglobulin (IVIg), first-line CIDP, is prescribed off-label aaSFPN despite very high cost. This project aimed conduct the first...
Mid-upper arm circumference (MUAC) is a simple, noninvasive anthropometric indicator. This study evaluated the applicability of MUAC as an alternative screening instrument to appendicular skeletal muscle mass index (ASMI) for detecting sarcopenia, and determined optimal cutoff values.A total 4509 subjects ≥50 years age from West China Health Aging Trend were included in present study. ASM was measured by bioelectrical impedance analysis. MUAC, calf (CC), grip strength Short Physical...
Neuroinflammation and autophagy are implicated in stress-related major depressive disorder (MDD), but the underlying molecular mechanisms remain largely unknown.
Neuroinflammation is tightly associated with onset of depression. The nuclear receptor related 1 protein (Nurr1, also called Nr4a2), its roles in dopaminergic neurons well understood, which can alleviate inflammation. Nevertheless, potential effects Nr4a2 on neuroinflammation depression still remains unclear. Chronic lipopolysaccharides (LPS) stress induced depressive-behaviors were confirmed via behavioral tests. Differentially expressed genes detected by using RNA-sequencing. anterior...
Abstract Atherosclerosis is one of the leading causes death worldwide. miR-26 a potential biomarker atherosclerosis. Standardized diagnostic tests for (MIR26-DX) have been developed, but fastest progress has in predicting efficacy IFN-α therapy hepatocellular carcinoma (HCC, phase 3). MiR-26 slows atherosclerosis development by suppressing ACC1/2, ACLY, ACSL3/4, ALDH3A2, ALPL, BMP2, CD36, COL1A1, CPT1A, CTGF, DGAT2, EHHADH, FAS, FBP1, GATA4, GSK3β, G6PC, Gys2, HMGA1, HMGB1, LDLR, LIPC,...
Abstract Receptor for advanced glycation end-products (RAGE) and TLR4 play an important role in the inflammatory response against High-mobility group box 1 protein (HMGB1), a late proinflammatory cytokine damage-associated molecular pattern. As cell surface receptors, both RAGE are constantly trafficking between cytoplasm plasma membrane. However, whether is related to intracellular transport of HMGB1-induced inflammation remains unknown. In this study, we demonstrated that HMGB1 not only...
Abstract Background Sarcopenia is a condition that characterized by loss of muscle mass, strength and functional impairment with ageing. It associated poor health outcomes, premature death significant burden on the global economy. The prevalence sarcopenia in China unknown since most studies are lack uniform standard. study was undertaken to association cognitive among multi-ethnic adults aged 50 years old or older western China. Methods We measured gait speed, handgrip mass using...
Abstract Major depressive disorder (MDD) is a prevalent and debilitating psychiatric mood that lacks objective laboratory-based tests to support its diagnosis. A class of microRNAs (miRNAs) has been found be centrally involved in regulating many molecular processes fundamental central nervous system function. Among these miRNAs, miRNA-134 (miR-134) reported related neurogenesis synaptic plasticity. In this study, the hypothesis plasma miR-134 can used diagnose MDD was tested. Perturbation...
Abstract Objectives Associations between cognitive decline and depression have been inconclusive. We examined 1) whether sleep quality mediates these relationships 2) which factor of relationships. Methods This study utilized baseline data from the 2018 West China Health Aging Trend (WCHAT), a large cohort data-set that including participants aged over 50 years old. defined using 15-item Geriatric Depression Scale (GDS-15). Cognitive status was measured Short Portable Mental Status...
The gut microbiome and fecal metabolites have been found to influence sarcopenia, but whether there are potential bacteria that can alleviate sarcopenia has under-investigated, the molecular mechanism remains unclear.
Abstract Background Sarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress uric acid (UA) has strong antioxidant properties. aim this study was investigate relationship between UA community-dwelling adults West China using baseline data Health Aging Trend (WCHAT) study. Design A cross-sectional Methods 4236 aged 50 years or older communities west were enrolled We applied Asian Working Group for (AWGS)...
The purpose of this study was to investigate the benefits exercises with different cognitive demands for functions (Executive and non-Executive) in healthy older adults. A cross-sectional design adopted. In total, 84 adults were enrolled study. They categorized into Tai Chi group (TG), brisk walking (BG) or control (CG). Each participant performed Stroop task a digit comparison task. included following three conditions: naming condition, an inhibition condition executive condition. There two...
Background: As the fight against COVID-19 epidemic continues, medical workers may have allostatic load. Objective: During reopening of society, and nonmedical were compared in terms Methods: An online study was performed; 3,590 Chinese subjects analyzed. Socio-demographic variables, load, stress, abnormal illness behavior, global well-being, mental status, social support assessed. Results: There no difference load to (15.8 vs. 17.8%; p = 0.22). Multivariate conditional logistic regression...