A5035843064- Cardiovascular Health and Disease Prevention
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Transport and Channel Regulation
- MicroRNA in disease regulation
- Blood Pressure and Hypertension Studies
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Fungal Biology and Applications
- Enzyme Production and Characterization
- Spine and Intervertebral Disc Pathology
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Immune Cell Function and Interaction
- Polysaccharides and Plant Cell Walls
- Liver physiology and pathology
- Nerve injury and regeneration
- MRI in cancer diagnosis
- Metabolomics and Mass Spectrometry Studies
- Glycosylation and Glycoproteins Research
- Immune cells in cancer
- Seaweed-derived Bioactive Compounds
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
Chengdu University of Traditional Chinese Medicine
2025
Material (Belgium)
2025
Nanjing University of Aeronautics and Astronautics
2025
Wuhan No.1 Hospital
2021-2024
Tangshan Gongren Hospital
2024
South China Agricultural University
2024
Loma Linda University
2012-2024
Hanshan Normal University
2021-2024
Shanghai Jiao Tong University
2020-2023
Jinhua Academy of Agricultural Sciences
2020-2023
Abstract As a result of their pluripotency and potential for unlimited self‐renewal, human embryonic stem cells (hESCs) hold tremendous promise in regenerative medicine. An essential prerequisite the widespread application hESCs is establishment effective efficient protocols large‐scale cell culture, storage, distribution. At laboratory scales are cultured adherent to tissue culture plates; these techniques labor‐intensive do not scale high numbers. In an effort facilitate larger hESC...
Ulcerative colitis, a major inflammatory bowel disease, is an idiopathic disorder of the colonic mucosa, accompanied by aberrant immune reaction to intestinal microflora. Macrophages are central mediators homeostasis and inflammation. The relationship between macrophages pathogenesis colitis poorly understood. We aimed characterize changing populations roles M1/M2 in colitis. demonstrated that M1 increased M2 decreased Interleukin (IL)-23 Tumor necrosis factor-α induction IL-10 suppression....
Octacosanol has multiple biological functions. In this study, the anti-inflammatory effect and molecular mechanism of octacosanol were evaluated by using dextran sulfate sodium (DSS)-induced ulcerative colitis model in mice lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cells. The was induced 3.0% DSS 8-week ICR orally administered with 100 mg/kg/day. results showed that significantly improved health status reduced DSS-induced pathological damage colonic tissues. obviously...
In Western countries and China, the dietary habit of high calories usually results in hyperlipidemia, which is closely associated with cardiovascular diseases. study, we investigated antihyperlipidemic effect oryzanol its molecular mechanism fat diet (HFD) mouse model. total, 60 ICR mice were randomly divided into control group, HFD HFD+Ory group. The from group additionally fed 100 mg/kg by intragastric administration. Our data indicated that treatment for 10 weeks significantly reduced...
Hyperlipidemia occurs very often in modern society along with a high calorie intake and is regarded as one of the greatest risk factors for prevalence cardiac vascular disease (CVD). In this study, we investigated anti-hyperlipidemic effect rice bran polysaccharides (RBP) its mechanism fat diet animal model. 60 ICR mice were randomly divided into 3 groups, which included Control, HFD (high diet) + RBP, each group 20 mice. The control was fed standard while other two groups HFD. addition, RBP...
Curcumin, a natural product derived from the plant Curcuma longa, has been found to have anti-inflammatory, antineoplastic and antifibrosis effects. It reported that curcumin attenuates allergic airway inflammation in mice through inhibiting NF-κB its downstream transcription factor GATA3. also proved effect of down-regulating Notch1 receptor nuclear levels. In this study, we aimed investigate anti-inflammatory on acute asthma underlying mechanisms. 36 male BALB/c were randomly divided into...
Current glioma therapies allow in situ delivery of cytotoxic drugs to the tumour; however, gliomas show early recurrence due their highly proliferative character. Long non-coding (lnc)RNAs play critical roles tumorigenesis by controlling cell proliferation and cycling. However, mechanism action lncRNAs development remains unclear. Here, we report that lncRNA PLAC2 induces cycle arrest targeting ribosomal protein (RP)L36 glioma. RPL36 promoted G1/S progression. Mass spectrometry analysis...
A protein engineering strategy based on efficient and focused mutagenesis implemented by codon-based was developed. Vitaxin, a humanized version of the antiangiogenic antibody LM609 directed against conformational epitope α v β 3 integrin complex, used as model system. Specifically, in stepwise fashion to rapidly improve affinity antigen binding fragment greater than 90-fold. In complete absence structural information about Vitaxin-α interaction, phage-expressed libraries for all six Ig...
Scope In this study, the anti-inflammatory effects and molecular mechanism of alliin were analyzed in dextran sulfate sodium (DSS)-induced colitis mice lipopolysaccharide-stimulated RAW264.7 cell model. Methods The phenotype was recorded DSS-induced and/or (500 mg/kg) groups. Histopathological alterations by H&E staining. MPO MDA colon tissues measured. mRNA expression levels inflammatory factors determined qRT-PCR, protein expressions or activation kinases Western blotting. Results Oral...
Abstract Receptor for advanced glycation end-products (RAGE) and TLR4 play an important role in the inflammatory response against High-mobility group box 1 protein (HMGB1), a late proinflammatory cytokine damage-associated molecular pattern. As cell surface receptors, both RAGE are constantly trafficking between cytoplasm plasma membrane. However, whether is related to intracellular transport of HMGB1-induced inflammation remains unknown. In this study, we demonstrated that HMGB1 not only...
To evaluate the anti-inflammatory effect of β-glucans from<italic>Lentinus edodes</italic>, and its molecular mechanism, dextran sulfate sodium salt (DSS) induced colitis model mice LPS-stimulated RAW264.7 cell inflammation were used in this study.
Abstract Brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of post-stroke depression (PSD). However, precise function and potential mechanism proBDNF, precursor form BDNF, are unknown. In our study, a PSD-like model was established by treating neuronal cells with oxygen-glucose deprivation corticosterone. We found that protein proBDNF levels were significantly higher cortex hippocampus PSD group than control group, suggesting PSD. Furthermore, we...
Cancer vaccines combined with immune checkpoint blockades (ICB) represent great potential application, yet the insufficient tumor antigen presentation and immature dendritic cells hinder improved efficacy. Here, a hybrid nano vaccine composed by hyper branched poly(beta-amino ester), modified iron oxide adjuvant messenger RNA (mRNA) encoded model ovalbumin (OVA) is presented. The outperforms three commercialized reagents loaded same mRNA, including Lipofectamine MessengerMax, jetPRIME, in...
Current laboratory methods used to passage adherent human pluripotent stem cells (hPSCs) are labor intensive, result in reduced cell viability and incompatible with larger scale production necessary for many clinical applications. To meet the current demand hPSCs, we have developed a new non-enzymatic passaging method using sodium citrate. Sodium citrate, formulated as hypertonic solution, gently efficiently detaches cultures of hPSCs small multicellular aggregates minimal manual...
δ-Tocotrienol, an important component of vitamin E, has been reported to possess some physiological functions, such as anticancer and anti-inflammation, however their molecular mechanisms are not clear. In this study, δ-tocotrienol was isolated purified from rice bran. The anti-inflammatory effect mechanism against lipopolysaccharides (LPS) activated pro-inflammatory mediator expressions in RAW264.7 cells were investigated. Results showed that significantly inhibited LPS-stimulated nitric...
Abstract BACKGROUND Literature has demonstrated that diabetes is associated with renal complication and testicular dysfunctions. The current study explored the potential of Tiliacora triandra extract its major component against diabetic kidney damages in rats. METHODS Diabetes was induced by high fat diet/streptozotocin (HFD/STZ) treated orally (TTE, 100 400 mg kg −1 body weight) component, 5,7‐dihydroxy‐6‐oxoheptadecanoic acid (DHA, 25 for 30 consecutive days. Testicular activities enzymes,...