A5100324300- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Autoimmune and Inflammatory Disorders Research
- Cancer-related Molecular Pathways
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Complementary and Alternative Medicine Studies
- Dermatologic Treatments and Research
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Extracellular vesicles in disease
- Retinoids in leukemia and cellular processes
- Asymmetric Hydrogenation and Catalysis
- Colorectal Cancer Surgical Treatments
- Natural Compounds in Disease Treatment
- Chemical Synthesis and Analysis
- interferon and immune responses
- Reproductive System and Pregnancy
- TGF-β signaling in diseases
- Gastric Cancer Management and Outcomes
- Inflammasome and immune disorders
Yueyang Hospital
2018-2025
Shanghai University of Traditional Chinese Medicine
2018-2025
Southeast University
2023-2024
State Key Laboratory of Digital Medical Engineering
2023-2024
Hebei Medical University
2019-2024
State Key Laboratory of Natural Medicine
2021-2024
China Pharmaceutical University
2021-2024
Third Hospital of Hebei Medical University
2019-2024
Sichuan University
2009-2024
State Key Laboratory of Oral Diseases
2023-2024
Curcumin, a natural product derived from the plant Curcuma longa, has been found to have anti-inflammatory, antineoplastic and antifibrosis effects. It reported that curcumin attenuates allergic airway inflammation in mice through inhibiting NF-κB its downstream transcription factor GATA3. also proved effect of down-regulating Notch1 receptor nuclear levels. In this study, we aimed investigate anti-inflammatory on acute asthma underlying mechanisms. 36 male BALB/c were randomly divided into...
The gut microbiota plays important roles in chronic inflammation and colon cancer. Lactobacillus is a gut-resident probiotic with benefits to host health. We recently identified plantarum strain YYC-3 strong inhibition against two cancer cell lines (HT-29 Caco2). However, the inhibitory effect of vivo has not been verified. Thus, present study, we explored function its cell-free supernatant (YYCS) respectively APCMin/+ mouse model during tumour development growth, underlying anti-cancer...
Psoriasis is a chronic inflammatory skin disease associated with both innate and adaptive immune responses. The stimulator of interferon genes (STING) protein engages in sensing cytosolic DNA to initiate dsDNA-driven In vitro vivo anti-psoriasis effects STING antagonist H-151 were explored.We analysed the gene expression profile related downstream targets samples healthy people psoriasis patients from GEO database. Cellular inhibitory activity on pathway was confirmed via qPCR western...
A series of novel benzo[c][1,2,5]oxadiazole derivatives were designed, synthesized, and biologically evaluated as inhibitors PD-L1. Among them, compound L7 exhibited 1.8 nM IC50 value in a homogeneous time-resolved fluorescence (HTRF) assay, which was 20-fold more potent than the lead BMS-1016. In surface plasmon resonance (SPR) bound to human PD-L1 (hPD-L1) with KD 3.34 nM, without showing any binding hPD-1. cell-based coculture blocked PD-1/PD-L1 interaction an EC50 375 while BMS-1016 had...
The objective of this study was to investigate the impact surgical margin and hepatic resection on prognosis compare their importance in patients with hepatocellular carcinoma (HCC).The clinical data 906 HCC who underwent our hospital from January 2013 2015 were collected retrospectively. All divided into anatomical (AR) (n = 234) nonanatomical (NAR) group 672) according type resection. effects AR NAR wide narrow margins overall survival (OS) time recurrence (TTR) analyzed.In all patients,...
CD1d-restricted invariant NKT (iNKT) cells play a critical role in tumor immunity. However, the scarcity and limited persistence restricts their development clinical application. Here, we demonstrated that iNKT could be efficiently expanded using modified cytokines combination from peripheral blood mononuclear cells. Introduction of IL-21 significantly increased frequency CD62L-positive memory-like armoring with B7H3-targeting second generation CAR showed potent cell killing activity....
The efficacy and safety of Janus kinase (JAK) inhibitors as novel therapeutic agents for psoriasis (PSO) psoriatic arthritis (PsA) have not yet been systematically evaluated. Randomized controlled studies (RCTs) assessing JAK to treat PSO or PsA published before September 1, 2022, were searched in the PubMed, Embase, Cochrane Library databases. Psoriasis Area Severity Index (PASI) 75 American College Rheumatology (ACR) 50 established primary outcome indicators PsA, respectively. Adverse...
Abstract Adrenal incidentalomas (AIs) are commonly detected endocrine lesions, identified during imaging for unrelated conditions. These lesions exhibit considerable heterogeneity and diverse clinical outcomes. This study employed single‐cell RNA sequencing to investigate tumorigenic characteristics of AIs, including non‐functional adrenocortical adenomas, Conn's syndrome, pheochromocytomas. Through integrating public datasets, 302 696 cells analyzed. Three cell subtypes gene expression...