A5100323755- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Cytokine Signaling Pathways and Interactions
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Visual perception and processing mechanisms
- Neuroscience and Neural Engineering
- Neurogenesis and neuroplasticity mechanisms
- Mobile Ad Hoc Networks
- Receptor Mechanisms and Signaling
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Cooperative Communication and Network Coding
- Regulation of Appetite and Obesity
- T-cell and B-cell Immunology
- Nerve injury and regeneration
- Circadian rhythm and melatonin
- Anesthesia and Neurotoxicity Research
- Vagus Nerve Stimulation Research
- Axon Guidance and Neuronal Signaling
- Glaucoma and retinal disorders
- Memory and Neural Mechanisms
- Wireless Networks and Protocols
- Neuroinflammation and Neurodegeneration Mechanisms
University of Chicago
2015-2024
Anhui Medical University
2006-2024
Harbin Medical University
2024
Georgia State University
2020-2024
Neuroscience Institute
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Xiyuan Hospital
2022-2023
Beijing University of Chinese Medicine
2023
Nanchang University
2023
Wangjing Hospital of China Academy of Chinese Medical Sciences
2023
The changes in synaptic morphology and receptor content that underlie neural plasticity are poorly understood. Here, we use a pH-sensitive green fluorescent protein to tag recombinant glutamate receptors monitor their dynamics onto dendritic spine surfaces. We show chemically induced long-term potentiation (chemLTP) drives robust exocytosis of AMPA receptors. In contrast, the same stimulus produces small reduction NMDA from surface. chemLTP similar modification large spines. Interestingly,...
On-Off direction-selective retinal ganglion cells (DSGCs) encode the axis of visual motion. They respond strongly to an object moving in a preferred direction and weakly opposite, “null,” direction. Historically, DSGCs were classified into four subtypes according their directional preference (anterior, posterior, superior, or inferior). Here, we compare two genetically identified populations DSGCs: dopamine receptor 4 (DRD4)-DSGCs thyrotropin-releasing hormone (TRHR)-DSGCs. We find that...
Immunosuppression is a significant factor in the progression of tumor invasion and metastasis.Melatonin, well-known hormone, has certain cytotoxic immune regulatory effects to inhibit function.Exosomes are small membrane vesicles released by many kinds cells, which contain different macromolecules, such as mRNAs microRNAs (miRNAs), proteins that can mediate communications between cells.Tumor-derived exosomes may cause immunosuppression, however, it unknown whether melatonin attenuate an...
Previous research has shown that antioxidant (butylated hydroxyanisole) treatment ameliorates respiratory syncytial virus (RSV)-induced disease and lung inflammation. Melatonin been reported to exhibit a wide varieties of biological effects, including anti-inflammation, no evident toxicity side effect. But it is not known whether melatonin would modify RSV-induced oxidative stress. The present study was establish the involvement stress in pathogenesis inflammation, investigate protective...
Direction selectivity of direction-selective ganglion cells (DSGCs) in the retina results from patterned excitatory and inhibitory inputs onto DSGCs during motion stimuli. The are directionally tuned to antipreferred (null) direction therefore potently suppress spiking null direction. However, whether inhibition is indispensable for unclear. Here, we selectively eliminated directional tuning by disrupting GABA release presynaptic interneuron starburst amacrine cell mouse retina. We found...
The dendrites of starburst amacrine cells (SACs) in the mammalian retina are preferentially activated by motion centrifugal direction, a property that is important for generating direction selectivity selective ganglion (DSGCs). A candidate mechanism underlying SAC synaptic inhibition onto SACs. Here we disrupted this perturbing distinct sets GABAergic inputs SACs – removing either GABA release or receptors from We found lateral Off non-SAC required optimal pathway. In contrast, On not...
An increased hippocampal neurogenesis has been observed in Alzheimer disease (AD), the most common neurodegenerative disorder characterized with accumulation of β-amyloid (Aβ) and hyperphosphorylated tau (p-tau). Studies transgenic mouse models suggest that amyloidosis suppresses adult neurogenesis. Although emerging evidence links to neurodevelopment, direct data regarding phosphorylation is missing. Here, we found immature neurons, identified by doublecortin (DCX) neurogenic...
In this paper, we propose multiple tree construction schemes and routing protocols for video streaming over wireless ad hoc networks. The basic idea is to split the into parts send each part a different tree, which are constructed be disjoint with other so as increase robustness loss transmission degradations. Specifically, two novel multicast protocols. Our first scheme constructs trees in serial, but distributed fashion, referred serial protocol. It achieves reasonable connectivity while...
Direction selectivity in the retina is mediated by direction-selective ganglion cells. These cells are part of a circuit which they asymmetrically wired to inhibitory neurons. Thus, respond strongly an image moving preferred direction and weakly opposite (null) direction. Here, we demonstrate that adaptation with short visual stimulation cell using drifting gratings can reverse this cell's directional preference 180°. This reversal robust, long lasting, independent animal's age. Our findings...
Summary Aim Nerve growth factor ( NGF ) regulates neuronal survival and differentiation by activating extracellular signal‐regulated‐kinases ERK 1/2 phosphoinositide‐3‐kinase PI 3K)/Akt pathways in two distinct processes: latency process neurite extension process. This study was designed to investigate whether botanical drug C‐glucosylated isoflavone puerarin coordinates with regulate neuritogenesis via 3K/Akt Methods We investigated the neuroprotective neurotrophic activities of MPTP...